Solitary lymph node metastasis without local recurrence of primary chordoma

Sopta, Jelena; Tulic, Goran; Mijucic, Vesna; Mamontov, P N; Mandic, Nikica

doi:10.1007/s00586-008-0800-0

Cited by 12 publications

(9 citation statements)

References 24 publications

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“…The most common location is the sacrococcygeal region (40%-50%) and the base of the skull (35%-40%) followed by the vertebral bodies (15%-20%) [15,53]. Distant metastases to the lungs, bone, soft tissues, lymph nodes, liver, and skin have been reported in up to 43% of patients [12,27,48]. Treatment of chordomas is described in various studies [2, 4-6, 13, 14, 20, 26, 29, 31, 39, 44, 47, 56, 57].…”

Section: Introductionmentioning

confidence: 99%

Surgical Margins and Local Control in Resection of Sacral Chordomas

Ruggieri

Angelini

Ussia

et al. 2010

Clinical Orthopaedics &Amp; Related Research

169

152

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Background The treatment of choice in sacral chordoma is surgical resection, although the risk of local recurrence and metastasis remains high. The quality of surgical margins obtained at initial surgery is the primary factor to improve survival reducing the risk of local recurrence, but proximal sacral resections are associated with substantial perioperative morbidity. Questions/purposes We considered survivorship related to local recurrence in terms of surgical margins, level of resection, and previous surgery. Methods We retrospectively reviewed 56 patients with sacral chordomas treated with surgical resection. Thirtyseven were resected above S3 by a combined anterior and posterior approach and 19 at or below S3 by a posterior approach. Nine of these had had previous intralesional surgery elsewhere. The minimum followup was 3 years (mean, 9.5 years; range, 3-28 years). Results Overall survival was 97% at 5 years, 71% at 10 years, and 47% at 15 years. Survivorship to local recurrence was 65% at 5 years and 52% at 10 years. Thirty percent of patients developed metastases. Wide margins were associated with increased survivorship to local recurrence. We found no differences in local recurrence between wide and wide-contaminated margins (that is, if the tumor or its pseudocapsule was exposed intraoperatively, but further tissue was removed to achieve wide margins). Previous intralesional surgery was associated with an increased local recurrence rate. We observed no differences in the recurrence rate in resections above S3 or at and below S3. Conclusions Surgical margins affect the risk of local recurrence. Previous intralesional surgery was associated with a higher rate of local recurrence. Intraoperative contamination did not affect the risk of local recurrence when wide margins were subsequently attained.

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Section: Introductionmentioning

confidence: 99%

Surgical Margins and Local Control in Resection of Sacral Chordomas

Ruggieri

Angelini

Ussia

et al. 2010

Clinical Orthopaedics &Amp; Related Research

169

152

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“…Treatment is challenging because of their unique location, close vicinity to key structures, contiguous spread and relapse. The reported incidence of metastases in the literature vary widely from 3 to 48% with the lungs, liver, bone and lymph nodes being the commonly involved sites [1][2][3][4]. We describe two cases of metastatic sacral chordoma, stable on molecular targeted therapy.…”

Section: Introductionmentioning

confidence: 92%

“…Metastases are known to occur more commonly when the primary is located in the sacrococcygeal region, compared to the clivus [1]. Metastatic disease has been reported in almost every organ: lung, liver, bone, lymph node, brain, solid abdominal organs, peritoneum and even in the breast [1][2][3][4]18]. Occurrence range of the metastases has been reported to be as early as 2-3 months [19,20] to as late as 9-10 years after initial treatment [19].…”

Section: A B E F C Dmentioning

confidence: 99%

Metastatic Chordoma: Report of the Two Cases and Review of the Literature

et al. 2015

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Chordomas are rare malignant bone tumours with a predilection for the axial skeleton, especially the sacrum and skull base. Median survival in patients with metastatic disease is usually dismal. Treatment is challenging due to the propensity for local recurrence, metastatic disease as well as lack of clear consensus regarding the optimal management. Our case report highlights two cases of sacral chordoma with locally recurrent and widespread metastatic disease, stable on molecular targeted therapy. Keywords: Chordoma, metastasis, imatinib, positron emission tomography ÖzetKordomalar özellikle sakrum ve kafa tabanı ile eksenel iskelet yerleş-me eğiliminde olan, nadir görülen malign kemik tümörleridir. Metastatik hastalığı olan hastalarda sağkalım ortanca değeri genellikle umutsuzdur. Tedavi, lokal nüks, metastatik hastalık yanı sıra optimum tedaviye ilişkin net konsensus eksikliği nedeniyle zordur. Bizim olgu sunumumuzda moleküler hedefli tedavinin istikrarlı yerel tekrarlayan ve yaygın metastatik hastalığı olan sakral kordomayla ilgili iki olgu bulunmaktadır. Anahtar Kelimeler: Kordoma, metastaz, imatinib, pozitron emisyon tomografiCorrespondence to: Saurabh Rohatgi,

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“…Отмечены метастазы при светлоклеточной хондросаркоме [23], склерозирующей эпителиоидной фи-бросаркоме кости [24], лейомиосаркоме кости [25], карци-носаркоме кости [26], ангиосаркоме кости [27]. Описаны лимфогенные метастазы при всех формах хордомы -клас-сической хордоме [28], дедифференцированной хордоме [29], экстрааксиальной хордоме [30]. Встречаются метаста-зы в лимфатических узлах при гигантоклеточной опухоли кости [31] и ее злокачественном аналоге [32].…”

Section: Introductionunclassified

Lymph node metastasis of osteosarcomas

Vasiliev

2016

Arkh. patol.

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Первичные саркомы кости составляют менее 0,2% всех злокачественных опухолей человека [1,2]. Спектр нозологических форм костных процессов включает специ-фические злокачественные опухоли скелета, недиффе-ренцированные саркомы и мягкотканные саркомы -опухоли, гистогенетически типичные для мягких тканей. Специфические злокачественные опухоли объединяют остеосаркому, хондросаркому, саркому Юинга, адаман-тиному, хордому, злокачественную гигантоклеточную опухоль. Из них первые три опухоли в структуре заболева-емости костными саркомами составляют большинство -более 75% [1,2]. Частота встречаемости остеосаркомы, хондросаркомы и саркомы Юинга равна 35,1, 25,8 и 16% соответственно [1,2]. Мягкотканные саркомы чаще всего включают лейомиосаркому, ангиосаркому, синовиаль-ную саркому, липосаркому, злокачественную опухоль из оболочек периферических нервов [1, 2]. Метастазирова-ние костных сарком осуществляется преимущественно гематогенным путем -до 90% случаев [1]. Органом-ми-шенью для гематогенного метастаза являются, как прави-ло, легкие, реже -кости скелета, головной мозг [1][2][3]. Однако в малой части случаев метастазы поражают лим-фатические узлы. Метастазы в лимфатических узлах могут быть как солитарные, так и множественные [4,5]. Воз-можно метастатическое поражение не только «первого эшелона» лимфатической системы -регионарного аппа-рата, но и отдаленных групп лимфатических узлов, обна-руживаемых в средостении, забрюшинном пространстве, шее, парааортальной области [5][6][7]. Так, например, опи-саны метастазы остеосаркомы бедренной кости в лимфа-Васильев Николай

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Solitary lymph node metastasis without local recurrence of primary chordoma

Cited by 12 publications

References 24 publications

Surgical Margins and Local Control in Resection of Sacral Chordomas

Surgical Margins and Local Control in Resection of Sacral Chordomas

Metastatic Chordoma: Report of the Two Cases and Review of the Literature

Lymph node metastasis of osteosarcomas

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