Solubilities of solid mixtures in supercritical carbon dioxide: a review

Lucien, Frank P.; Foster, Neil R.

doi:10.1016/s0896-8446(99)00048-0

Cited by 184 publications

(159 citation statements)

References 44 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…In the last two decades, solubility in SCFs of a large number of different low-volatility compounds have been measured, reported, and reviewed. [9][10][11][12][13][14][15][16] However, the development of new supercritical processes and new applications for existing substances has maintained the need for new experimental solubility determinations.…”

Section: Introductionmentioning

confidence: 99%

Solubility of Flurbiprofen in Supercritical Carbon Dioxide

et al. 2004

View full text Add to dashboard Cite

Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.

show abstract

Section: Introductionmentioning

confidence: 99%

Solubility of Flurbiprofen in Supercritical Carbon Dioxide

et al. 2004

View full text Add to dashboard Cite

show abstract

“…The most applicable phase diagram for the binary solid-scCO2 systems in RESS and PGSS is shown in Fig. 6 [70,71]. The solid-liquid-vapor (S-L-V) lines intersect with the critical lines (L=V) at two distinguished point, i.e.…”

Section: Thermodynamics Studymentioning

confidence: 99%

Tailoring Particle Microstructures via Supercritical CO<sub>2</sub> Processes for Particular Drug Delivery

Liu¹,

Jiang

Wang³

2015

CPD

View full text Add to dashboard Cite

Strategies for a particular drug delivery are always of great interest for the pharmaceutical industry, and efficient methods of preparing products with controlled particle microstructures are fundamental for the development and application of drug delivery. Supercritical fluid particle design (SCF PD) processes, as a green and effective alternative to traditional methods, have been effectively employed to produce particles with designated microstructures.Combining with research experiences in our research group, this review aims to provide a theoretical framework of SCF PD for particular drug delivery. For any drug delivery formulations, macroscopic properties are directly influenced by the particle microstructures, "Inverse" strategies are introduced at first to obtain the needed particle microstructures for a particular drug delivery in this paper. Then, how to produce particles with designated microstructures via SCF PD processes is discussed, mainly focus on the screening and selection of operating parameters according to thermodynamics and fluid dynamics study. Recent examples of SCF micronization and co-precipitation/ encapsulation processes are also summarized with an emphasis on how to tailor the particle microstructures by controlling the operating parameters.Finally, challenges and issues needed further study are briefly suggested for SCD PD.

show abstract

“…Bartle et al (1991b) reviewed the solubilities of solids and liquids of low volatility in supercritical carbon dioxide. Lucien and Foster (2000) reviewed the solubilities of solid mixtures in supercritical carbon dioxide and Erkey (2000) reviewed the extraction of metals from aqueous solutions by using supercritical carbon dioxide. Guclu-Ustundag and Temelli (2000) reviewed the solubilities of lipids in supercritical carbon dioxide.…”

Section: Solubilitymentioning

confidence: 99%

“…Several reviews articles have been reported for experimental data and techniques for phase equilibrium measurement, e.g., Deiters and Schneider (1986), Fornari et al (1990), Bartle et al (1991b), Dohrn and Brunner (1995), Lucien and Foster (2000), and for diffusivity measurement, e.g., Liong et al (1991a) and Suarez et al (1998). Saito (1995) reviewed the research activities on supercritical fluid science and technology in Japan.…”

Section: Introductionmentioning

confidence: 99%