Solubility and density isotherms for potash alum-water-acetone

Mydlarz, J.; Jones, Alan G.

doi:10.1021/je00057a029

Cited by 8 publications

(4 citation statements)

References 5 publications

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“…Among these properties, polymorphismthe ability of a compound to adopt more than one crystal structureplays a fundamental role in choosing the solid state form of a medicinal. This is because polymorphism is a widespread observed phenomenon for organic molecules and the different solid phases of the same substance might exhibit diverse physical−chemical attributes such as solubility, dissolution rate, thermal/mechanical stability, etc. − In pharmaceutical field, properties such as these might impact downstream manufacture operations − as well as shelf life and bioavailability of drugs. , For these reasons a polymorphic form is patentable.…”

Section: Introductionmentioning

confidence: 99%

Fine Dosage of Antisolvent in the Crystallization of l-Histidine: Effect on Polymorphism

Profio

Caridi

Caliandro

et al. 2009

Crystal Growth & Design

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In this work, the antisolvent membrane crystallization process has been used to influence the polymorphic composition in the crystallization of L-histidine. When finely dosing the amount of ethanol in the crystallizing solution, by generating the proper trans-membrane flux, the composition of the precipitate shifts regularly from the prevalence of the thermodynamic stable polymorph A toward the predominance of the metastable phase B. Form A crystals are always the first to nucleate, thus following an "anti-Ostwald rule" behavior and in accordance with classical nucleation theory previsions. However, as the antisolvent content exceeds a threshold limit, the number of phase A crystals progressively reduces and the first weak nucleation is followed by a second massive production of a powder of the polymorph B. The elapsed time between the two events reduces as the antisolvent dosing flux increases. This result might be due to a combined effect on the nucleation and growth rates when the amount of ethanol exceeds the critical value. No significant membrane fouling was observed over the duration of the experiments, and stable fluxes were observed. A slight increase in membrane permeability, due to the reduced hydrophobicity when using a high initial amount of ethanol, was observed.

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Section: Introductionmentioning

confidence: 99%

Fine Dosage of Antisolvent in the Crystallization of l-Histidine: Effect on Polymorphism

Profio

Caridi

Caliandro

et al. 2009

Crystal Growth & Design

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“…Product quality and efficacy are often contingent on adequate control of particle size and shape in the crystallizer. The size of material produced in a crystallizer can have a detrimental impact on downstream unit operations such as the filtration rate, − drying and formulation operations…”

Section: Introductionmentioning

confidence: 99%

A Review of the Use of Process Analytical Technology for the Understanding and Optimization of Production Batch Crystallization Processes

Barrett

Smith

Worlitschek

et al. 2005

Org. Process Res. Dev.

128

103

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Crystallization at production scale is typically a poorly understood unit operation, with little implementation of the first principles aspect of crystallization in its design, optimization, and control. Problems with production crystallizers include the following: (1) inconsistencies of batch-to-batch in terms of the size and number of crystals produced and (2) the purity profile (residual impurities in crystals, or wrong polymorph or chiral purity). This can have a significant impact both on product quality and downstream process unit operations including filtration, drying, milling, and product formulation. This contribution reviews typical problems encountered in production crystallization, with case studies, advice, and strategies to understand and avoid these problems through the use of in situ crystallization characterization tools.

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“…Researchers have used several approaches to dealing with such crystal size distribution's (CSDs) data. These include growth rate dispersion (GRD) (RANDOLPH, LARSON ; BERGLUND, DE JONG, 1990; LIANG, HARTEL; MYDLARZ 1992; MYDLARZ, BRIEDIS 1992) or size-dependent growth rate (SDG) (RANDOLPH, LARSON; MYDLARZ, JONES 1989;1990a, b, 1993MYDLARZ, BRIEDIS 1992;MYDLARZ 1994). This current paper describes the use of the GRD and SDG for modelling these MSMPR crystallizer CSD data, for which log population density is approximately a linear function of the crystal size.…”

Section: Introductionmentioning

confidence: 99%

The estimation of crystallization kinetics from linear in n(L) versus L steady‐state data including growth rate dispersion

Mydlarz

1995

Cryst. Res. Technol.

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Dedicated to Professor Roman KOCH on the occasion of his 75th birthday A discussion of modelling of nucleation and crystal growth kinetics is presented for those mixedsuspension, mixed product removal (MSMPR) crystallizer data available in the literature, for which log population density data appears to be a linear function of crystal size. The modelling crystallization kinetics is done twice -once assuming that the system IS obeying McCabe's AL law, and again when the crystals exhibit growth rate dispersion (GRD). In the latter case the gamma, inverse gamma, log-normal, beta, Fisher, sum of two gammas, sum of two inverse gammas. sum of two log-normal, and sum of two constant rates of growth rate dispersion models are used for crystal growth rate estimation. Finally, McCabe's and G R D predictions are compared with the size-dependent growth rate estimations.Modelle fur die Kinetik der Keimbildung und des Kristallwachstums werden diskutiert fur solche .,mixed-suspension, mixed product removal (MSMPR)" Kristallisationsdaten aus der Literatur fur welche die Ergebnisse der logarithmischen GroBenverteilung eine lineare Funktion der KristallgroBe zu sein scheint. Die Kristallisationskinetik wurde auf zwei Weisen modelliert -einmal unter der Annahme daB das System dem McCabe AL Gesetz folgt und ein weiteres Ma1 wenn die Kristalle Dispersion der Wachstumsrate, .,growth rate dispersion (GDR)", zeigen. Im letzferen Fall wurden Modelle von gamma, inverse gamma, log-normal, beta, Summe von zwei gammas, Summe von zwei inversen gammas, Summe zweier log-normal, und die Summe von zwei konstanten Wachstumsraten benutzt um die Kristallwachstumsraten abzuschatzen. SchlieRlich wurden McCabes und G R D Vorhersagen mit den Abschatzungen von groDenabhangigen Wachstumsraten verglichen.

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Solubility and density isotherms for potash alum-water-acetone

Cited by 8 publications

References 5 publications

Fine Dosage of Antisolvent in the Crystallization of l-Histidine: Effect on Polymorphism

Fine Dosage of Antisolvent in the Crystallization of l-Histidine: Effect on Polymorphism

A Review of the Use of Process Analytical Technology for the Understanding and Optimization of Production Batch Crystallization Processes

The estimation of crystallization kinetics from linear in n(L) versus L steady‐state data including growth rate dispersion

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