Solubility Determination and Thermodynamic Properties of Bezafibrate in Pure and Binary Mixed Solvents

Abstract

In this work, the solubility of bezafibrate in 16 pure solvents including 9 alcohols (methanol, ethanol, n-propanol, iso-propanol, n-butanol, iso-butanol, sec-butanol, 1-pentanol, and iso-pentanol), 4 alkyl acetate (ethyl acetate, n-propyl acetate, n-butyl acetate, and methyl propionate), 2 ketones (methyl ethyl ketone and cyclohexanone) and one nitrile (acetonitrile) and in binary mixed solvents (methanol + acetonitrile) at temperature of 283.15–323.15 K was determined. The solubility of bezafibrate in pure solvents was simulated using modified Apelblat, Van’t Hoff, Wilson, and NRTL model. That in binary mixed solvents was simulated using the modified Apelblat and Apelblat–Jouyban–Acree model. The thermodynamic mixing properties (Δmix G, Δmix H, Δmix S, γ1 ∞, and H 1 E,∞) of the bezafibrate-pure solvent systems were evaluated based on the solubility data and Wilson model.

Solubility and Model Correlation of Doxofylline in Pure Solvents at the Temperature Range of 283.15–323.15 K

“…In a binary dissolution system, the Wilson model can be used to calculate the activity coefficient of the solute, which is described as shown by eqs –. , where λ 12 , λ 21 , a 12 , b 12 , a 21 , and b 21 are the interaction parameters and V 1 and V 2 are the molar volumes of solute and solvent, respectively.…”

“…In a binary dissolution system, the Wilson model can be used to calculate the activity coefficient of the solute, which is described as shown by eqs 6−8. 26,27 Ä…”

“…) and the reduced excess enthalpy (H 1 E,∞ ) at infinitesimal concentration can be shown as eqs 21 and 22. 26,27 ln( ) ln 1…”

Solubility Determination and Thermodynamic Modeling of Amitriptyline Hydrochloride in 13 Pure Solvents at Temperatures of 283.15–323.15 K

“…The solubility data of AMT have been regressed with 5 models. In order to evaluate the goodness of the regressions, relative average deviation (RAD) and root-mean-square deviation (RMSD) are employed as indexes, which are defined as eqs 13 and 14: 15,16…”

“…The solubility data of AMT have been regressed with 5 models. In order to evaluate the goodness of the regressions, relative average deviation (RAD) and root-mean-square deviation (RMSD) are employed as indexes, which are defined as eqs and : , where N is the number of experimental points and x i and x i cal represent the experimental mole fraction solubility and calculated mole fraction solubility of the AMT, respectively. The regression results and the values of the indexes are listed in Tables –.…”