Solubility Determination, Thermodynamic Modeling, and Solvent Effect of 2′,4′-Dihydroxyacetophenone in 10 Monosolvents and Two Binary Solvents from 293.15 to 333.15 K

Abstract

The solubility of 2′,4′-dihydroxyacetophenone (2′,4′-DHAP) in 10 monosolvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, methyl acetate, ethyl acetate, propyl acetate, and benzene) and two binary solvents (ethanol + ethyl acetate and n-propanol + ethyl acetate) was determined using a gravimetric method at 101.3 kPa from 293.15 to 333.15 K. The experimental solubility was demonstrated to increase with the increasing temperature. The solubility of 2′,4′-DHAP is the highest in pure isopropanol, and the two binary solvents present a solubilizing effect on the solute. Furthermore, six thermodynamic models were employed to fit the solid–liquid equilibrium data, and the correlation results manifested that the modified Apelblat model had minimum ARD values of less than 1%. Finally, the KAT-LSER model was employed to analyze the solvent effect at 298.15 K. The results show that the contribution of the four interaction types α, β, π*, and δH account for 15.84%, 15.30%, 18.33%, and 50.53% of the total interaction force, respectively, and the solvent–solvent interaction represented by δH is the dominant factor affecting the solubility of 2′,4′-DHAP.

Solubility of Mono‐Aminoacridines

“…The authors have cited additional references within the Supporting Information. [50][51][52][53][54][55][56][57][58][59][60][61][62][63]…”

Determination of L-Glutamine Solubility in 12 Pure Solvent Systems from 283.15 to 323.15 K

“…The production of amino acids involves fermentation, crude separation, and purification processes, with the end product being a crystalline powder. In the process of improving product purity and yield by crystallization, it is crucial to determine the solubility data of l -glutamine in organic solvent systems . However, there are only two reports on the solubility data of l -glutamine.…”

“…In the process of improving product purity and yield by crystallization, 8 it is crucial to determine the solubility data of L-glutamine in organic solvent systems. 9 However, there are only two reports on the solubility data of L-glutamine. In 2013, the solubility of L-glutamine in two mixed solvents, ethanol + water and acetone + water, was measured and published in the temperature range of 278.15−313.15 K by Yu et al 7 Subsequently, in 2017, the solubility data of L-glutamine in ethanol solvent was measured and published by Bowden et al 10 The solubility of L-glutamine in other solvent systems is still unknown.…”