Solubility enhancement of curcumin via fast-dissolving electrospun nanofibrous mats comprising jelly fig polysaccharides and Pullulan

Hartini, Nina; Wu, Yu-Shan; Kusumaningtyas, Ratna Dewi; Sriariyanun, Malinee; Wu, Jia-Jiuan; Cheng, Yu-Shen

doi:10.1016/j.jtice.2024.105346

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…The incorporation of micronized API is essential to enhance the film's texture and ensure quick dissolution and consistency in the fast-disintegrating film (Nautiyal., 2023). Various drug categories can be adapted for mouth-dissolving films, addressing diverse medical needs (Hartini et al, 2024). These encompass pediatrics (anti-tussive, expectorants), geriatrics (expectorants, antiepileptic), disorders of the gastrointestinal tract (cytostatic therapy), pain management (e.g., migraine), and CNS disorders (Table . 2).…”

Section: Drugmentioning

confidence: 99%

Oral Disintegrating Films: A Review

Raihan,

Wafa,

Zhakfar

et al. 2024

JNSR

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The oral route stands out as a preferred method for drug administration due to its cost-effectiveness and ease, contributing to enhanced patient compliance. Some individuals, particularly the geriatric and pediatric populations, encounter difficulties swallowing conventional tablets and hard gelatin capsules. To address this, oral disintegrating drug delivery systems are established as substitutes for tablets, capsules, and syrups. Notably, fast-dissolving oral thin films offer a practical solution for patients such as those in pediatric, bedridden, or developmentally disabled categories, as well as the geriatric population who struggle with a tablet or hard gelatin capsule ingestion. This innovative dosage form involves the creation of thin films consuming water-soluble polymers that quickly disintegrate and dissolve in the mouth cavity. It serves as a substitute stage for those particles that undergo significant metabolism of drugs in the liver. This study provides an overview of numerous dosage form-formulations, preparation approaches, and quality control measures related to fast-disintegrating films.

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Section: Drugmentioning

confidence: 99%

Oral Disintegrating Films: A Review

Raihan,

Wafa,

Zhakfar

et al. 2024

JNSR

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“…Curcumin-encapsulated electrospun materials have apparently been more researched. Recently, a fast-dissolving electrospun polysaccharide fibrous film loaded with curcumin was fabricated for the fast delivery of curcumin in the mouth [ 18 ]. A polylactic acid-based electrospun composite material loaded with curcumin was reported to achieve antibacterial properties against E. coli and S. aureus [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Characterizations on a GRAS Electrospun Lipid–Polymer Composite Loaded with Tetrahydrocurcumin

Lin,

Li,

Huang

2024

Foods

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Electrospun/sprayed fiber films and nanoparticles were broadly studied as encapsulation techniques for bioactive compounds. Nevertheless, many of them involved using non-volatile toxic solvents or non-biodegradable polymers that were not suitable for oral consumption, thus rather limiting their application. In this research, a novel electrospun lipid–polymer composite (ELPC) was fabricated with whole generally recognized as safe (GRAS) materials including gelatin, medium chain triglyceride (MCT) and lecithin. A water-insoluble bioactive compound, tetrahydrocurcumin (TC), was encapsulated in the ELPC to enhance its delivery. Confocal laser scanning microscopy (CLSM) was utilized to examine the morphology of this ELPC and found that it was in a status between electrospun fibers and electrosprayed particles. It was able to form self-assembled emulsions (droplets visualized by CLSM) to deliver active compounds. In addition, this gelatin-based ELPC self-assembled emulsion was able to form a special emulsion gel. CLSM observation of this gel displayed that the lipophilic contents of the ELPC were encapsulated within the cluster of the hydrophilic gelatin gel network. The FTIR spectrum of the TC-loaded ELPC did not show the fingerprint pattern of crystalline TC, while it displayed the aliphatic hydrocarbon stretches from MCT and lecithin. The dissolution experiment demonstrated a relatively linear release profile of TC from the ELPC. The lipid digestion assay displayed a rapid digestion of triglycerides in the first 3–6 min, with a high extent of lipolysis. A Caco-2 intestinal monolayer transport study was performed. The ELPC delivered more TC in the upward direction than downwards. MTT study results did not report cytotoxicity for both pure TC and the ELPC-encapsulated TC under 15 μg/mL. Caco-2 cellular uptake was visualized by CLSM and semi-quantified to estimate the accumulation rate of TC in the cells over time.

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