Solubility Increment and Thermodynamic Analysis of Bioactive Antofloxacin Hydrochloride in Aqueous ChCl/PTS Deep Eutectic Solvent and Cosolvent Mixtures

Zhang, Ying; Du, Cunbin; Cong, Yang; Xue, Yi; Qiao, Bin; Ye, Tingting; Wang, Mingliang

doi:10.1021/acs.jced.9b00717

Cited by 5 publications

(3 citation statements)

References 27 publications

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“…These donors include urea, amide, carboxylic acid, and polyol. Receptors include quaternary ammonium salts and zwitterions. , With the increasing demand for green solvents, DESs have received widespread attention in the fields of natural product extraction, catalysis, pharmaceutical processes, and adsorbents . DESs are also called second-generation ionic liquids (ILs) because of their excellent properties, such as low vapor pressures, a wide liquid range, low price, simple preparation processes, and low melting points, and have become ideal substitutes for traditional solvents and ILs …”

Section: Introductionmentioning

confidence: 99%

Infinite Dilution Activity Coefficients and Thermodynamic Properties of Various Organic Solutes in a Choline Chloride + Oxalic Acid Deep Eutectic Solvent

Wang

Yalikun

et al. 2022

J. Chem. Eng. Data

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Inverse gas chromatography (IGC) was used to determine a series of thermodynamic parameters for a deep eutectic solvent (DES) composed of choline chloride (CHCl) and oxalic acid (OA) in a 1:1 molar ratio at temperatures ranging between 303.15 and 343.15 K. The infinite dilution activity coefficients (γ12 ∞) and Flory–Huggins interaction parameters (χ12 ∞) of 31 organic solutes with different chemical properties in the DES were determined to predict the separation ability of the DES and the miscibility between the DES and solutes, respectively. The results show that alcohols and acetonitrile are good solvents for the DES. The selectivity (S 12 ∞) and capacity (k 2 ∞) of DES were determined for azeotropic mixtures of acetone (1)/ethanol (2), cyclohexane (1)/ethanol (2), n-heptane (1)/thiophene (2), benzene (1)/methanol (2), and tetrachloromethane (1)/methanol (2), showing that the DES is an effective separation agent for the tetrachloromethane (1)/methanol (2) and acetone (1)/ethanol (2) systems compared with the reported solvents. Furthermore, the Hildebrand solubility parameters (δ2) of the examined DES were determined at different temperatures using the Guillet method and provide a theoretical basis for solute selection.

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Section: Introductionmentioning

confidence: 99%

Infinite Dilution Activity Coefficients and Thermodynamic Properties of Various Organic Solutes in a Choline Chloride + Oxalic Acid Deep Eutectic Solvent

Wang

Yalikun

et al. 2022

J. Chem. Eng. Data

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“…Both the chemical stability and the antimicrobial activity of the two antibiotics was increased several folds by incorporation into the solvents compared with an aqueous solution. The solubility of antofoxacin hydrochloride, an antibiotic in the fluoroquinolone family, was found to be increased in a deep eutectic solvent composed of choline chloride:para-toluenesulfonic acid 1:2 compared with ethanol:water and ethanol:acetonitrile mixtures (Zhang et al, 2019).…”

Section: Anti-microbial Drugsmentioning

confidence: 99%

Deep Eutectic Solvents for Innovative Pharmaceutical Formulations

Nguyen

Augis

Fourmentin

et al. 2020

Environmental Chemistry for a Sustainable World

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Finding alternative solvents for industrial processes, such as chemical synthesis or extraction of biologically active molecules that are less toxic and more environmentally friendly than the organic solvents used up to now, is a major societal issue. These alternative solvents are often described as "green, biodegradable" solvents. Deep eutectic solvents, which are mixtures of simple and often naturally occurring compounds, have been extensively studied in this regard. Among their possible applications, there has been increasing interest in their use for the preparation of pharmaceutical formulations. Indeed, by changing the nature and ratio of their components, deep eutectic solvents can be adapted to a wide range of active molecules, from poorly soluble small molecules to labile macromolecules. The use of deep eutectic solvents to solubilize active molecules with low aqueous solubility and/or low permeability could be an alternative approach to increase their dissolution and in-vivo absorption. This could result in significant increases of bioavailability or enhanced therapeutic efficacy of currently marketed drugs. Moreover, deep eutectic solvents can be used to limit phenomena like polymorphism or degradation which present a challenge to drug formulation. However, despite being generally described as biodegradable and nontoxic due to the nature of their constituents, the safety of deep eutectic solvents, which possess both novel physico-chemical and biological properties, cannot be taken for granted and must therefore be carefully studied during development stages. Therefore, this chapter presents not only recent progress in the application of deep eutectic solvents in the development of formulations for improving therapeutic efficacy by different routes of administration but also studies that have been undertaken to investigate the toxicity of deep eutectic solvents to both living organisms and the environment.

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“…antibiotics and non-steroidal anti-inflammatory drugs) have also been successfully demonstrated by the introduction of therapeutic DES (THEDES) for oral and transdermal drug delivery. 19,20 However, these stabilisation effects are not yet fully understood and should be additionally investigated on a case-by-case basis using computational and experimental methods.…”

Section: Introductionmentioning

confidence: 99%

Deep eutectic solvents as a stabilising medium for NAD coenzyme: unravelling the mechanism behind coenzyme stabilisation effect

et al. 2022

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Solubility Increment and Thermodynamic Analysis of Bioactive Antofloxacin Hydrochloride in Aqueous ChCl/PTS Deep Eutectic Solvent and Cosolvent Mixtures

Cited by 5 publications

References 27 publications

Infinite Dilution Activity Coefficients and Thermodynamic Properties of Various Organic Solutes in a Choline Chloride + Oxalic Acid Deep Eutectic Solvent

Infinite Dilution Activity Coefficients and Thermodynamic Properties of Various Organic Solutes in a Choline Chloride + Oxalic Acid Deep Eutectic Solvent

Deep Eutectic Solvents for Innovative Pharmaceutical Formulations

Deep eutectic solvents as a stabilising medium for NAD coenzyme: unravelling the mechanism behind coenzyme stabilisation effect

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