Solubility measurement and data correlation of 2-ethoxy-1-naphthoic acid in twelve pure solvents at temperatures from 278.15 to 323.15 K

Yuan, Haowei; Yang, Jing; Wang, Mengling; Li, Huimin; Li, Yu; Li, Tao; Ren, Baozeng

doi:10.1016/j.jct.2024.107365

The Journal of Chemical Thermodynamics

2025

DOI: 10.1016/j.jct.2024.107365

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Solubility measurement and data correlation of 2-ethoxy-1-naphthoic acid in twelve pure solvents at temperatures from 278.15 to 323.15 K

Haowei Yuan,

Jing Yang,

Mengling Wang

et al.

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Cited by 2 publications

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Solubility, correlation, Hansen solubility parameter and thermodynamic properties of 2-naphthoxyacetic acid in three binary mixed solvents

Li,

Liu

et al. 2024

The Journal of Chemical Thermodynamics

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Solubility, correlation, Hansen solubility parameter and thermodynamic properties of 2-naphthoxyacetic acid in three binary mixed solvents

Li,

Liu

et al. 2024

The Journal of Chemical Thermodynamics

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Thermodynamic Assessment of the Pyrazinamide Dissolution Process in Some Organic Solvents

Tovar-Amézquita,

Rincón-Guio,

Torres-Suarez

et al. 2024

Molecules

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Pyrazinamide is a first line drug used for the treatment of tuberculosis, a pathology that caused the death of more than 1.3 million people in the world during 2022, according to WHO, being a drug of current interest due to its relevance in pharmaceutical and medical sciences. In this context, solubility is one of the most important physicochemical parameters in the development and/or optimization of new pharmaceutical forms, so the present work aims to present a thermodynamic study of the solubility of pyrazinamide in nine organic solvents of pharmaceutical interest. Using the shake-flask method and UV/Vis spectrophotometry, the solubility of this drug was determined at 9 temperatures; the maximum solubility was obtained in dimethyl sulfoxide at 318.15 K (x2=0.081.6±0.004) and the minimum in cyclohexane at 283.15 K (1.73±0.05×10−5). From the apparent solubility data, the thermodynamic functions of solution and mixing were calculated, indicating an endothermic process. In addition, the solubility parameter of pyrazinamide was calculated using the Hoftyzer-van Krevelen (32.90 MPa1/2) and Bustamante (28.14 MPa1/2) methods. The maximum solubility was reached in dimethyl sulfoxide and the minimum in cyclohexane. As for the thermodynamic functions, the entropy drives the solution process in all cases. In relation to the solubility parameter, it can be analyzed that the mathematical models offer approximations; however, the experimental data are still primordial at the time of inferring any process.

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Solubility measurement and data correlation of 2-ethoxy-1-naphthoic acid in twelve pure solvents at temperatures from 278.15 to 323.15 K

Cited by 2 publications

References 46 publications

Solubility, correlation, Hansen solubility parameter and thermodynamic properties of 2-naphthoxyacetic acid in three binary mixed solvents

Solubility, correlation, Hansen solubility parameter and thermodynamic properties of 2-naphthoxyacetic acid in three binary mixed solvents

Thermodynamic Assessment of the Pyrazinamide Dissolution Process in Some Organic Solvents

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