Solubility, Mechanical and Biological Properties of Fluoridated Hydroxyapatite/Calcium Silicate Gradient Coatings for Orthopedic and Dental Applications

Yin, Xue Guo; Bai, Yu; Zhou, Sheng-jian; Ma, Wen; Bai, Xue; Chen, Weidong

doi:10.1007/s11666-020-00981-3

Cited by 12 publications

(3 citation statements)

References 50 publications

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“…F-HA showed good apatite-like layer deposition ability [67], can promote cell adhesion and protein adsorption, and improved ALP activity in cell culture [68]. It can obviously prevent the decrease of bone mineral density caused by osteoporosis [69,70], and inhibit bacteria growth [71,72].…”

Section: Fluorine Doped Hydroxyapatite (F-ha)mentioning

confidence: 99%

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

et al. 2021

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Hydroxyapatite (HA) is widely used in bone tissue engineering for its bioactivity and biocompatibility, and a growing number of researchers are exploring ways to improve the physical properties and biological functions of hydroxyapatite. Up to now, HA has been used as inorganic building blocks for tissue engineering or as nanofillers to blend with polymers, furthermore, various methods such as ion doping or surface modification have been also reported to prepare functionalized HA. In this review, we try to give a brief and comprehensive introduction about HA-based materials, including ion-doped HA, HA/polymer composites and surface modified HA and their applications in bone tissue engineering. In addition, the prospective of HA is also discussed. This review may be helpful for researchers to get a general understanding about the development of hydroxyapatite based materials.

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Section: Fluorine Doped Hydroxyapatite (F-ha)mentioning

confidence: 99%

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

et al. 2021

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“…However, no adequate information was provided to explain the variation in the mechanical properties. Fluoridated hydroxyapatite/calcium silicate gradient coatings through the plasma spraying method showed the hardness value in the FHA-rich area was 2.59 ± 0.12 GPa the middle and CS-rich area were 1.61 ± 0.18 and 1.69 ± 0.11 GPa, respectively . Compared to the FHA-rich area, reducing the hardness at the middle and CS-rich areas is attributed to high porosity.…”

Section: Multifunctional Behavior Of Bulk Fgms and Fgcsmentioning

confidence: 99%

Promises of Functionally Graded Material in Bone Regeneration: Current Trends, Properties, and Challenges

Dubey

Jaiswal

Lahiri

2022

ACS Biomater. Sci. Eng.

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Functionally graded materials (FGMs) are emerging materials systems, with structures and compositions gradually changing in a particular direction. Consequently, the properties of the materials gradually change in the desired direction to achieve particular nonhomogeneous service demands without abrupting the compositional and behavioral interface at the macroscale. FGMs have been found to have high potential as orthopedic implants; because the functional gradient can be adapted in such a manner that the core of FGM should be compatible with the density and strength of bone, interlayers can maintain the structural integrity and outermost layers would provide bioactivity and corrosion resistance, thus overall tailoring the stress shielding effect. This review article discusses the typical FGM systems existing in nature and the human body, focusing on bone tissue. Further, the reason behind the application of these FGMs systems in orthopedic implants is explored in detail, considering the physical and biological necessities. The substantial focus of the present critical review is devoted to two primary topics related to the usage of FGMs for orthopedic implants: (1) the synthesizing techniques currently available to produce FGMs for load-bearing orthopedic applications and (2) the properties, such as mechanical, structural, and biological behavior of the FGMs. This review article gives an insight into the potential of FGMs for orthopedic applications.

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“…Plasma spraying has a number of associated limitations; the high solidification rate of feedstock and the formation of the amorphous phase, and the appearance of cracks or issues bonding between HA layer and titanium [21,22]. Nevertheless, plasma-sprayed HA coatings have been the subject of intense research over time [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Plasma-Sprayed Hydroxyapatite Coatings and Their Biological Properties

et al. 2022

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Air plasma spraying (APS) is a common method of producing hydroxyapatite (HA) coatings for alloprosthetic implants. Modification of HA spraying potentially may diminish the risk of inflammation and local infection during bone implantation. Titanium implants were HA coated with different deposition process parameters. HA powder was deposited using APS with axial powder injection at three different distances (100, 120, and 140 mm). The surface morphology of each implant was examined and the direct contact cytotoxicity of each HA coating was evaluated according to norm ISO 10993 5:2009. The response of monocytes to HA was assessed via the activation of transcription nuclear factor. All coatings had a lamellar structure. HA sprayed at a distance of 120 mm showed the highest roughness and little phase change. The analysis of the results of the conducted research showed that plasma-spraying distance during the HA coating process had a negligible impact on biocompatibility. The results obtained for a distance of 120 mm showed a slight increase in the biological properties tested. Moreover, HA coatings sprayed at different distances were not cytotoxic and did not stimulate the NF-kB. Bare titanium was less susceptible to colonization by Staphylococcus aureus than HA-coated surfaces. HA constitutes a potentially good, low-cost, non-cytotoxic material for joint prostheses.

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Solubility, Mechanical and Biological Properties of Fluoridated Hydroxyapatite/Calcium Silicate Gradient Coatings for Orthopedic and Dental Applications

Cited by 12 publications

References 50 publications

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Hydroxyapatite Based Materials for Bone Tissue Engineering: A Brief and Comprehensive Introduction

Promises of Functionally Graded Material in Bone Regeneration: Current Trends, Properties, and Challenges

Plasma-Sprayed Hydroxyapatite Coatings and Their Biological Properties

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