2023
DOI: 10.1111/exd.14811
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Soluble adenylyl cyclase contributes to imiquimod‐mediated inflammation and is a potential therapeutic target in psoriasis

Abstract: Cyclic AMP (cAMP) has a key role in psoriasis pathogenesis, as indicated by the therapeutic efficacy of phosphodiesterase inhibitors that prevent the degradation of cAMP. However, whether soluble adenylate cyclase (sAC) (encoded by the ADCY10 gene), which is an important source for cAMP, is involved in Th17 cell‐mediated inflammation or could be an alternative therapeutic target in psoriasis is unknown. We have utilized the imiquimod model of murine psoriasiform dermatitis to address this question. Adcy10−/− m… Show more

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