Soluble adhesion molecules (E-selectin, ICAM-1 and VCAM-1) in breast carcinoma

O'Hanlon, D.M.; Fitzsimons, H; Lynch, Jill E.; Tormey, Shona; Malone, Carmel; Given, H. F.

doi:10.1016/s0959-8049(02)00218-6

Cited by 145 publications

(108 citation statements)

References 28 publications

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“…The identification of a susceptibility region influencing both breast and prostate cancer is particularly interesting because breast and prostate cancer have many common features, such as hormone-sensitivity, parallel incidence rates in various countries, and common genetic alterations (20). The role of intercellular adhesion molecules in cancer has been described (21,22). ICAM1 is constitutively expressed in cells involved in immune response and induced on other cells, including endothelial and epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus

et al. 2004

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We conducted a large-scale association study to identify genes that influence nonfamilial breast cancer risk using a collection of German cases and matched controls and >25,000 single nucleotide polymorphisms located within 16,000 genes. One of the candidate loci identified was located on chromosome 19p13.2 [odds ratio (OR) ‫؍‬ 1.5, P ‫؍‬ 0.001]. The effect was substantially stronger in the subset of cases with reported family history of breast cancer (OR ‫؍‬ 3.4, P ‫؍‬ 0.001). The finding was subsequently replicated in two independent collections (combined OR ‫؍‬ 1.4, P < 0.001) and was also associated with predisposition to prostate cancer in an independent sample set of prostate cancer cases and matched controls (OR ‫؍‬ 1.4, P ‫؍‬ 0.002). High-density single nucleotide polymorphism mapping showed that the extent of association spans 20 kb and includes the intercellular adhesion molecule genes ICAM1, ICAM4, and ICAM5. Although genetic variants in ICAM5 showed the strongest association with disease status, ICAM1 is expressed at highest levels in normal and tumor breast tissue. A variant in ICAM5 was also associated with disease progression and prognosis. Because ICAMs are suitable targets for antibodies and small molecules, these findings may not only provide diagnostic and prognostic markers but also new therapeutic opportunities in breast and prostate cancer.

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Section: Discussionmentioning

confidence: 99%

Large-Scale Association Study Identifies ICAM Gene Region as Breast and Prostate Cancer Susceptibility Locus

et al. 2004

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“…ICAM-1 plays an important role in cell adhesion to the vascular endothelium and may have a role in tumor cell dissemination or metastasis [18,19]. Suppressed expression of VCAM-1 and ICAM-1 is associated with reduced adhesion of monocytes and lymphocytes to human umbilical vein endothelial cell stimulated by cytokine [20].…”

Section: Discussionmentioning

confidence: 99%

Lipoprotein p37 from Mycoplasma hyorhinis inhibiting mammalian cell adhesion

et al. 2005

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Summaryp37 protein is a membrane lipoprotein of Mycoplasma hyorhinis, and our previous work showed that there was high ratio of M. hyorhinis infection in human gastric carcinoma. To investigate the possible functions of p37 in cancer development, the nucleotide sequence of p37 gene was modified and expressed well in transfected cells. We found that p37 localized at the Golgi apparatus and could be secreted out of the cell. Human gastric cancer cells AGS, after being transfected with the p37 gene, were smaller, more spherical and easy to detach from each other. Their adhesion to matrix was also diminished and cytoskeleton in these stable p37 AGS cell was rearranged and transcription co-factor b-actin was transferred to nucleolus with down-regulation of ICAM-1 and integrin b1. These findings will be helpful for us to elucidate the effects of p37 on eukaryotic cells as well as to better understand the potential relationship between cancer and mycoplasma infection.

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“…LTA inhibited rhTNF-α-mediated THP-1 cell adhesion to HT-29 Adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) are implicated in cancer progression (O'Hanlon et al, 2002;Rosette et al, 2005). In this study, the effect of pLTA on the TNF-α-induced expression of adhesion molecules was examined.…”

Section: Rhtnf-α Increased Il-8 Production In Ht-29 Cellsmentioning

confidence: 96%

“…TNF-α and nitric oxide (NO) trigger colonic inflammation and carcinogenesis in a Helicobacter hepaticus-infected mouse model, indicating that inflammation mediated by elevated TNF-α and NO causes colon carcinogenesis (Erdman et al, 2009;Kolios et al, 1996). Adhesion molecules, such as intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1), are also implicated in cancer progression (O'Hanlon et al, 2002;Rosette et al, 2005).…”

Section: Introductionmentioning

confidence: 99%