Soluble CD40 ligand: a novel biomarker in the pathogenesis of periodontal disease

Chaturvedi, Rashi; Gupta, Manmohan; Jain, Ashish; Das, Tarun; Prashar, Savita

doi:10.1007/s00784-014-1216-3

Cited by 13 publications

(13 citation statements)

References 49 publications

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“…This molecule is also essential for T‐helper cell activation, is a well‐known risk indicator of cardiovascular diseases and GCF levels of sCD40L can be elevated in periodontitis (Chaturvedi et al. ). Platelet‐derived growth factor BB is better known for its use in periodontal regeneration (Reynolds et al.…”

Section: Discussionmentioning

confidence: 99%

“…Soluble human CD40 ligand is a member of the TNF superfamily and it binds to CD40 on the surface of antigen-presenting cells and can activate B cell maturation (Hostager & Bishop 2013). This molecule is also essential for T-helper cell activation, is a well-known risk indicator of cardiovascular diseases and GCF levels of sCD40L can be elevated in periodontitis (Chaturvedi et al 2015). Platelet-derived growth factor BB is better known for its use in periodontal regeneration (Reynolds et al 2015), but its presence in GCF has been associated with phenytoininduced gingival enlargement (Kuru et al 2004).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Peri‐implant crevicular fluid biomarkers as discriminants of peri‐implant health and disease

Zani

Moss

Shibli

et al. 2016

J Clinic Periodontology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Peri‐implant crevicular fluid biomarkers as discriminants of peri‐implant health and disease

Zani

Moss

Shibli

et al. 2016

J Clinic Periodontology

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“…Platelets are the major source of sCD40L in the circulation [ 65 , 97 , 98 ]. The normal range of sCD40L in the serum of a healthy adult is estimated at 0.79 to 4.7 ng/mL, by means of immunoassay techniques [ 99 , 100 , 101 ].…”

Section: Platelet Cd40lmentioning

confidence: 99%

“…Accidents were attributed to other causes, which were sometimes reported as unidentified. Soluble CD40L gained attention when progress was made in the field of hemostasis and thrombosis, which outlined the role of platelets and leukocytes in the formation of atheroma plaque deposition and led to the proposal that cardiovascular disease is inflammatory [ 16 , 99 , 138 , 139 , 140 , 141 , 142 , 143 ].…”

Section: Cd40l and Platelet Component Transfusionmentioning

confidence: 99%

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

Aloui

Prigent

Sut

et al. 2014

IJMS

144

116

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The CD40 ligand (CD40L) is a transmembrane molecule of crucial interest in cell signaling in innate and adaptive immunity. It is expressed by a variety of cells, but mainly by activated T-lymphocytes and platelets. CD40L may be cleaved into a soluble form (sCD40L) that has a cytokine-like activity. Both forms bind to several receptors, including CD40. This interaction is necessary for the antigen specific immune response. Furthermore, CD40L and sCD40L are involved in inflammation and a panoply of immune related and vascular pathologies. Soluble CD40L is primarily produced by platelets after activation, degranulation and cleavage, which may present a problem for transfusion. Soluble CD40L is involved in adverse transfusion events including transfusion related acute lung injury (TRALI). Although platelet storage designed for transfusion occurs in sterile conditions, platelets are activated and release sCD40L without known agonists. Recently, proteomic studies identified signaling pathways activated in platelet concentrates. Soluble CD40L is a good candidate for platelet activation in an auto-amplification loop. In this review, we describe the immunomodulatory role of CD40L in physiological and pathological conditions. We will focus on the main signaling pathways activated by CD40L after binding to its different receptors.

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“…21 Contrary to our result on the negative correlation between periodontitis severity and sCD40L salivary levels, a recent case-control study reported a positive correlation between this marker in GCF and periodontitis severity. 22 To our knowledge, there are no published studies on the correlation of periodontal severity and the expression of the other two biomarkers tested (i.e. Granzyme B and AFP).…”

Section: Discussionmentioning

confidence: 96%

Novel biomarkers of periodontitis and/or obesity in saliva—An exploratory analysis

Recker

Brogden

Ávila‐Ortiz

et al. 2015

Archives of Oral Biology

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Objective Recent studies point to the clinical and research utility of saliva as a valuable diagnostic aid for monitoring periodontal health. The objectives of this study were to detect novel biomarkers attributed to chronic inflammation in saliva and to determine if the levels of these markers correlate with severity of periodontitis and with standard obesity measures in participants in a periodontal maintenance program. Design In this cross-sectional assessment of 63 participants, unstimulated whole saliva was collected after recording anthropometric and clinical parameters of obesity and periodontitis, respectively. The levels of interleukin-1 receptor antagonist (IL-1ra), sCD40L, granzyme B and alpha-fetoprotein (AFP) in saliva were determined using multiplex proteomic immunoassays. The correlation between the four tested biomarker concentrations and obesity/periodontal measures was determined. Results Positive correlation between fat% and granzyme B levels (r=0.292; p=0.020) and negative correlation between BMI and sCD40L (r=0.256;p=0.043) was observed. In addition, positive correlation between severity of periodontal disease and levels of IL1-ra (r=0.253; p=0.046) and negative correlation between periodontitis severity and sCD40L salivary levels (r=0.272; p=0.031) was noted. None of the above correlations remained statistically significant after multiple comparisons adjustment. After adjustment for clinical covariates, the relationship between sCD40L and periodontal severity remained suggestive (p=0.081). Conclusions Levels of four novel biomarkers of periodontitis were detectable in saliva of subjects enrolled in a periodontal maintenance program. Prospective studies with larger sample sizes and other populations are warranted to explore the diagnostic applicability of these markers.

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Soluble CD40 ligand: a novel biomarker in the pathogenesis of periodontal disease

Abstract: Positive association of its local levels with those in serum further implicates the possibility of widespread systemic effects of this infection.

Cited by 13 publications

References 49 publications

Peri‐implant crevicular fluid biomarkers as discriminants of peri‐implant health and disease

Peri‐implant crevicular fluid biomarkers as discriminants of peri‐implant health and disease

The Signaling Role of CD40 Ligand in Platelet Biology and in Platelet Component Transfusion

Novel biomarkers of periodontitis and/or obesity in saliva—An exploratory analysis

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