Soluble CD44 and CD44v6 and prognosis in children with B-cell acute lymphoblastic leukemia

Amirghofran, Zahra; Asiaee, Elham; Kamazani, Fatemeh M.

doi:10.1111/ajco.12268

Cited by 10 publications

(8 citation statements)

References 20 publications

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“…However, sCD44 was higher in patients with white blood cells (WBCs) .50 3 10 9 /L than patients with WBC \50 3 10 9 /L and in patients with a peripheral blast percentage .50 compared to patients with a peripheral blast percentage \50, presence of splenomegaly, extramedullary involvement, and in some cytogenetic conditions. 29 Elevation in serum sCD44 levels was detected in patients with MDS compared to healthy controls and correlated with poor prognosis. 30 These data suggest that sCD44 has its origins in tumors by proteolytic cleavage of the CD44, making it a potential reliable biomarker of clinical monitoring and prognosis marker in hematological diseases.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

“…30 These data suggest that sCD44 has its origins in tumors by proteolytic cleavage of the CD44, making it a potential reliable biomarker of clinical monitoring and prognosis marker in hematological diseases. 29,32 As far as we know, no data are available about serum levels of sN-cadherin and sEpCAM in hematological malignancies.…”

Section: Hematological Malignanciesmentioning

confidence: 99%

“…19 Moreover, the soluble forms of some of these surface markers increase in the serum of patients with hematological malignancies, such as leukemia. [29][30][31][32][33][34] As the source of the soluble forms are the membrane-bound proteins, one question can be raised: can the serum levels of soluble forms be correlated with the surface protein expression on the leukemic cells? In this review, we highlighted the role of these four adhesion molecules in carcinomas and hematological malignancies, mainly leukemia, and discuss evidence about this matter.…”

Section: Introductionmentioning

confidence: 99%

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Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

et al. 2018

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Some surface markers are used to discriminate certain leukemic subpopulations that retain a greater oncogenic potential than others, and, for this reason, they were termed as leukemic stem cells, similar to the concept of cancer stem cells in carcinoma. Among these surface markers are proteins involved in cell-cell adhesion or cell-matrix adhesion, and they may play a role in the relapse of leukemia, similar to metastasis in carcinomas. The most important are epithelial cadherin, neural cadherin, epithelial cell-adhesion molecule, and CD44, which can be cleaved and released, and their soluble forms were found increased in serum levels of cancer patients, being implicated, in some cases, with progression, metastases, and relapse. In this review, we highlighted the role of these four adhesion molecules in carcinomas and hematological malignancies, mainly leukemia, and discuss if the serum levels of soluble forms can be correlated with the surface protein status on the leukemic cells. Accession of the soluble forms looks attractive, but their use as markers in cancer must be studied in association with other parameters, as there are significant changes in levels in other pathological conditions besides cancer. Studies correlating the levels of the forms with the status of the membrane-bound proteins in leukemic (stem) cells and correlating those parameters with relapse in leukemia may afford important knowledge and applicability of those serum markers in clinical practice. For instance, the expression of the membrane-bound forms of these adhesion proteins may have promising clinical use in leukemia and other hematological malignancies.

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Section: Hematological Malignanciesmentioning

confidence: 99%

Section: Hematological Malignanciesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

et al. 2018

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“…Soluble CD44v6 has great potential as a biomarker. The expression of soluble CD44v6 in the serum could be used to discriminate patients from controls in children with B-cell acute lymphoblastic leukemia (B-ALL) 15. In stage I/II colorectal cancer, the diagnosis based on combined soluble CD44v6 and CEA is more valuable than that of CD44v6 or CEA alone 16.…”

Section: Introductionmentioning

confidence: 99%

CD44v6 Targeted by miR-193b-5p in the Coding Region Modulates the Migration and Invasion of Breast Cancer Cells

Hu¹,

Cao²,

Zhang³

et al. 2020

J. Cancer

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Previous studies have shown that CD44 containing variant exon v6 (CD44v6) is highly expressed in many cancers and is related to tumor metastasis. However, the detailed mechanism of the regulatory pattern of CD44v6 in breast cancer remains unclear. Here, we found that CD44v6 was significantly upregulated in invasive breast cancer cell lines compared with low-invasive breast cancer cell lines. Cell migration and invasion could be suppressed by CD44v6 downregulation. MiRWalk and RNAhybrid software revealed miR-193b-5p as a miRNA targeting CD44v6 by binding to the exon v6 region. We found that the overexpression of miR-193b-5p inhibited the migration and invasion of Hs-578t and BT-549 cells, which could be rescued by restoring the expression of CD44v6. Next, we determined the potential of miR-193b-5p as an in vitro biomarker for breast cancer. Serum samples were obtained from 58 breast cancer patients, 36 patients with benign disease and 58 age-matched cancer-free controls. The results showed that the expression of miR-193b-5p in the serum was significantly lower in breast cancer patients than in controls and could distinguish cancer from cancer-free samples. The area under the receiver operating characteristic curve (ROC) for miR-193b-5p was 0.762(95% confidence interval: 0.674-0.851), which was higher than that of carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3). Combining miR-193b-5p with CEA or CA15-3 could improve the diagnostic efficiency compared with the CEA and CA15-3 combination. Taken together, our results suggest that miR-193b-5p could function as a tumor-suppressive miRNA by targeting CD44v6 in breast cancer and that serum miR-193b-5p may serve as a biomarker for breast cancer diagnosis.

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“…Níveis séricos de sCD44 e sE-caderina são elevados em pacientes com várias doenças malignas hematológicas, incluindo leucemias pediátricas, em comparação com indivíduos saudá-veis (AMIRGHOFRAN et al, 2016;KHAN et al, 2008;TACYILDIZ et al, 2001;TAKEUCHI et al, 1999;TAKUBO et al, 2002).…”

Section: (Figura 3)unclassified

Expressão dos níveis séricos de sCD44, sE-caderina e sEpCAM no seguimento de crianças com Leucemia Linfoblástica Aguda

Fonseca¹

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Soluble CD44 and CD44v6 and prognosis in children with B-cell acute lymphoblastic leukemia

Cited by 10 publications

References 20 publications

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

Cell-adhesion molecules and their soluble forms: Promising predictors of “tumor progression” and relapse in leukemia

CD44v6 Targeted by miR-193b-5p in the Coding Region Modulates the Migration and Invasion of Breast Cancer Cells

Expressão dos níveis séricos de sCD44, sE-caderina e sEpCAM no seguimento de crianças com Leucemia Linfoblástica Aguda

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