Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property

Wu, Yusheng; Song, Yang; Geng, Xinyu; Ma, Fei; Mo, Li‐Hua; Zhang, Xiaowen; Liu, Dabo; Liu, Zhigang; Yang, Ping‐Chang

doi:10.7150/ijbs.38722

Cited by 17 publications

(13 citation statements)

References 23 publications

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“…A very recent study brought up a new view on the mode of action of sCD83 in the regulatory network of immune responses: by binding to CD154 on Th2 cells, sCD83 represses the apoptotic inhibitor Bcl2L12, thereby promoting cell death of this particular T cell subset (70). As a corollary, administration of sCD83 to animals with allergic rhinitis (AR) alleviated disease symptoms by restricting the Th2 response.…”

Section: Cd83 Binding Partners and Signaling Cascadesmentioning

confidence: 99%

The CD83 Molecule – An Important Immune Checkpoint

et al. 2020

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The CD83 molecule has been identified to be expressed on numerous activated immune cells, including B and T lymphocytes, monocytes, dendritic cells, microglia, and neutrophils. Both isoforms of CD83, the membrane-bound as well as its soluble form are topic of intensive research investigations. Several studies revealed that CD83 is not a typical co-stimulatory molecule, but rather plays a critical role in controlling and resolving immune responses. Moreover, CD83 is an essential factor during the differentiation of T and B lymphocytes, and the development and maintenance of tolerance. The identification of its interaction partners as well as signaling pathways have been an enigma for the last decades. Here, we report the latest data on the expression, structure, and the signaling partners of CD83. In addition, we review the regulatory functions of CD83, including its striking modulatory potential to maintain the balance between tolerance versus inflammation during homeostasis or pathologies. These immunomodulatory properties of CD83 emphasize its exceptional therapeutic potential, which has been documented in specific preclinical disease models.

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Section: Cd83 Binding Partners and Signaling Cascadesmentioning

confidence: 99%

The CD83 Molecule – An Important Immune Checkpoint

et al. 2020

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“…It has been found that soluble CD83 (sCD83) had immune regulatory functions [20]. Our recent publications show that sCD83 suppresses Th2 response [21]. Royzman et al [10] found that administration of sCD83 could inhibit rheumatoid arthritis in an sCD83/indoleamine-2, 3-dioxygenase/TGF-β-dependent manner.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy

Jin

et al. 2021

J Innate Immun

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The mechanism of generation of antigen-specific regulatory T cells (Treg) is not fully understood yet. This study aimed to investigate the role of intestinal epithelial cell (IEC)-derived CD83 in the Treg generation in the intestine. In this study, the role of CD83 in the generation of Tregs was assessed in a cell-culture model and a food allergy (FA) mouse model. We found that mouse IECs expressed CD83; its levels were markedly lower in sensitized mice. Mice with CD83-deficient IECs failed to induce Tregs in the intestine. CD83 promoted the transforming growth factor-β-inducible early gene 1 (TIEG1) expression in CD4<sup>+</sup> T cells. Toll-like receptor 4 (TLR4)/myeloid differentiation protein-2 (MD-2) complex mediated the effects of CD83 on the expression of TIEG1. Activation of the CD83/TLR4/MD-2/TIEG1 promoted the Treg generation. Concomitant administration of CD83 and specific antigens, but not either one alone, efficiently inhibited experimental FA via inducing the Treg generation in the intestine. In Conclusion, IEC expresses CD83 that is low in sensitized mice. Concomitant administration of CD83 and specific antigens efficiently inhibits FA in a murine model via inducing Tregs in the intestine. The data suggest that CD83 has translation potential in the treatment of FA.

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“…The above information suggests that epithelial cell‐derived factors may involve immune tolerance establishment by Treg generation in the airway mucosa. Our recent work shows that CD83 can suppress antigen‐specific Th2 response in the nasal mucosa 16 . Others found that CD83 attenuates autoimmune disorders 17 .…”

Section: Introductionmentioning

confidence: 91%

“…Our recent work shows that CD83 can suppress antigenspecific Th2 response in the nasal mucosa. 16 Others found that CD83 attenuates autoimmune disorders. 17 CD83 is a member of the immunoglobulin family; it can be produced by B cells and dendritic cells and usually used as a marker of dendritic cells.…”

Section: Introductionmentioning

confidence: 99%

Epithelial cell‐derived CD83 restores immune tolerance in the airway mucosa by inducing regulatory T‐cell differentiation

Luo

Yang

et al. 2021

Immunology

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The mechanism of generation of regulatory T cells (Treg) remains incompletely understood. Recent studies show that CD83 has immune regulatory functions. This study aims to investigate the role of epithelial cellderived CD83 in the restoration of immune tolerance in the airway mucosa by inducing the Treg differentiation. In this study, CD83 and ovalbumin (OVA)-carrying exosomes were generated from airway epithelial cells. An airway allergy mouse model was developed to test the role of CD83/OVA-carrying exosomes in the suppression of airway allergy by inducing Treg generation. We observed that mouse airway epithelial cells expressed CD83 that could be up-regulated by CD40 ligand. The CD83 deficiency in epithelial cells retarded the Treg generation in the airway mucosa. CD83 up-regulated transforming growth factor-b-inducible early gene 1 expression in CD4 + T cells to promote Foxp3 expression. Exposure of primed CD4 + T cells to CD83/OVA-carrying exosomes promoted antigen-specific Treg generation. Administration of CD83/OVA-carrying exosomes inhibited experimental airway allergic response. In summary, airway epithelial cells express CD83 that is required in the Treg differentiation in the airway mucosa. Administration of CD83/OVA-carrying exosomes can inhibit airway allergy that has the translation potential in the treatment of airway allergic disorders.

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Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property

Cited by 17 publications

References 23 publications

The CD83 Molecule – An Important Immune Checkpoint

The CD83 Molecule – An Important Immune Checkpoint

Intestinal Epithelial Cell-Derived CD83 Contributes to Regulatory T-Cell Generation and Inhibition of Food Allergy

Epithelial cell‐derived CD83 restores immune tolerance in the airway mucosa by inducing regulatory T‐cell differentiation

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