Soluble factors from human endometrium promote angiogenesis and regulate the endothelial cell transcriptome

Print, Cristin G.; Valtola, Reija; Evans, Amanda; Lessan, Khashayar; Malik, Shazia; Smith, Stephen K.

doi:10.1093/humrep/deh411

Cited by 30 publications

(18 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To the best of our knowledge, no previous studies have been published regarding the activity of these inflammatory and angiogenesis markers in menstrual blood of woman with endometriosis in comparison to serum levels. As for VEGF, we found only two studies evaluating VEGF-A in menstrual blood in women with and without endometriosis [45,46].…”

Section: Discussionmentioning

confidence: 99%

Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

Silva

Belo

Andrade

et al. 2014

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

Silva

Belo

Andrade

et al. 2014

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

“…An alternative in vitro system was used by Print et al [94]. Supernatants were collected from cultured endometrium and were found to contain soluble factors, which were able to stimulate proliferation and angiogenesis in cultures of human umbilical endothelial cells in vitro.…”

Section: Role Of Vegf In Endometrial Angiogenesismentioning

confidence: 99%

“…Gene array technology was used to examine the effect of the supernatants on gene expression in human umbilical vein endothelial cells. The supernatants obtained from cultured endometrium (proliferative and, to a lesser extent, secretory) induced significant pro-angiogenic changes including increased expression of several angiogenic promoters (for example: CXC receptor-4, VE-cadherin, endoglin, PECAM-1) [94]. Gene arrays have also been used to examine gene expression in cultured human endometrial endothelial cells following oestrogen or progestin (MPA) treatment [26].…”

Section: Role Of Vegf In Endometrial Angiogenesismentioning

confidence: 99%

Recent advances in endometrial angiogenesis research

2005

View full text Add to dashboard Cite

This review summarises recent research into the mechanisms and regulation of endometrial angiogenesis. Understanding of when and by what mechanisms angiogenesis occurs during the menstrual cycle is limited, as is knowledge of how it is regulated. Significant endometrial endothelial cell proliferation occurs at all stages of the menstrual cycle in humans, unlike most animal models where a more precise spatial relationship exists between endothelial cell proliferation and circulating levels of oestrogen and progesterone. Recent stereological data has identified vessel elongation as a major endometrial angiogenic mechanism in the mid-late proliferative phase of the cycle. In contrast, the mechanisms that contribute to post-menstrual repair and secretory phase remodelling have not yet been determined. Both oestrogen and progesterone/progestins appear to have paradoxical actions, with recent studies showing that under different circumstances both can promote as well as inhibit endometrial angiogenesis. The relative contribution of direct versus indirect effects of these hormones on the vasculature may help to explain their pro- or anti-angiogenic activities. Recent work has also identified the hormone relaxin as a player in the regulation of endometrial angiogenesis. While vascular endothelial growth factor (VEGF) is fundamental to endometrial angiogenesis, details of how and when different endometrial cell types produce VEGF, and how production and activity is controlled by oestrogen and progesterone, remains to be elucidated. Evidence is emerging that the different splice variants of VEGF play a major role in regulating endometrial angiogenesis at a local level. Intravascular neutrophils containing VEGF have been identified as having a role in stimulating endometrial angiogenesis, although other currently unidentified mechanisms must also exist. Future studies to clarify how endometrial angiogenesis is regulated in the human, as well as in relevant animal models, will be important for a better understanding of diseases such as breakthrough bleeding, menorrhagia, endometriosis and endometrial cancer.

show abstract

“…Endometrial supernatants were also shown to induce endothelial cell proliferation, which is partially mediated by VEGF-A [51]. In addition, supernatants from human endometrium added to human umbilical cord endothelial cell (HUVEC) cultures induced the expression of multiple gene products involved in vessel development [51].…”

Section: Induction Of Angiogenesismentioning

confidence: 99%

“…In addition, supernatants from human endometrium added to human umbilical cord endothelial cell (HUVEC) cultures induced the expression of multiple gene products involved in vessel development [51]. The CXC receptor-4, MMP-2, tissue factor inhibitor-2 and VE-cadherin are genes known to be involved in angiogenesis and are upregulated by VEGF-A in endothelial cells [52--54].…”

Section: Induction Of Angiogenesismentioning

confidence: 99%

Vascular development in endometriosis

et al. 2005

View full text Add to dashboard Cite

Endometriosis, defined as the presence of endometrial tissue outside the uterus, is an estrogen-dependent disease which causes pelvic pain and subfertility in women of reproductive age. The condition has a dramatic impact on the professional, social and marital life of sufferers. Direct and indirect evidence suggests that angiogenesis is required for the development and persistence of endometriosis. In this review the state-of-the-art with regard to our understanding of the role of angiogenesis in the ectopic implantation and survival of menstrual endometrial tissue will be discussed.

show abstract

Soluble factors from human endometrium promote angiogenesis and regulate the endothelial cell transcriptome

Cited by 30 publications

References 57 publications

Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

Identification of local angiogenic and inflammatory markers in the menstrual blood of women with endometriosis

Recent advances in endometrial angiogenesis research

Vascular development in endometriosis

Contact Info

Product

Resources

About