Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation

Liu, Xinguang; Liu, Yu; Chen, Feng

doi:10.18632/oncotarget.12533

Cited by 24 publications

(20 citation statements)

References 108 publications

(140 reference statements)

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“…In clinical settings, serum and tissue sFGL2 levels are a surrogate for Treg activity in patients with chronic viral hepatitis C [23]. Our results indicated that sFGL2 may also be a surrogate for Treg activity in patients with CA [31].…”

Section: Discussionmentioning

confidence: 67%

Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Zeng

2020

J Infect Dev Ctries

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Introduction: An imbalance in type 1 (Th1) and type 2 (Th2) T helper cells is associated with the development and recurrence of condyloma acuminatum (CA); however, the mechanisms underlying this imbalance remain unknown. We investigated soluble fibrinogen-like protein 2 (sFGL2), which is an effector of regulatory T cells (Tregs), to determine its role in the Th1/Th2 imbalance of CA. Methodology: Lesion and blood samples were obtained from 30 CA patients, and these samples were compared with genital skin and blood samples from 20 control subjects. Serum sFGL2, mRNA, and protein levels were estimated using ELISA, quantitative real-time polymerase chain reaction, and western blot, respectively. Immunohistochemical analyses were also conducted. Results: Compared to controls, CA patients had decreased serum sFGL2 levels. However, sFGL2 mRNA and protein levels in the lesions of CA patients were signiﬁcantly increased. Interleukin (IL)-4 and Foxp3 mRNA levels were upregulated, and interferon (IFN)-γ levels were downregulated in CA patients compared to those in controls. Additionally, the sFGL2 mRNA level positively correlated with Foxp3 and IL-4 levels and negatively correlated with IFN-γ and IL-17 levels. Conclusion: sFGL2 contributes to the underlying Th1/Th2 imbalance in CA pathogenesis.

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Section: Discussionmentioning

confidence: 67%

Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Zeng

2020

J Infect Dev Ctries

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“…FGL2 is a member of the fibrinogen superfamily of proteins, which are mainly expressed by inflammatory cells, including macrophages, CD4 + T, CD8 + T, and endothelial cells [ 10 ]. FGL2 can oligomerize into a tetramer by forming interchain disulfide bonds.…”

Section: Discussionmentioning

confidence: 99%

“…Fibrinogen-like protein 2 (FGL2) belongs to the fibrinogen-like protein family [ 10 ], which is mainly expressed in macrophages, T cells, endothelial cells, and tumor cells. FGL2 is a vital immune regulator of both innate and adaptive responses, with pleiotropic effects [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer

et al. 2020

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“…Fibrinogen-like protein 2 (FGL2) plays important roles in both innate and adaptive immunity (Liu, Liu & Chen, 2017). The FGL2 protein is located on the surface of endothelial cells and macrophages (Yang & Hooper, 2013).…”

Section: Introductionmentioning

confidence: 99%

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma

Yuan

Feng

Wang

et al. 2020

PeerJ

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Lung cancer is the most common malignant tumor, accounting for 25% of cancerrelated deaths and 14% of new cancers worldwide. Lung adenocarcinoma is the most common type of pulmonary cancer. Although there have been some improvements in the traditional therapy of lung cancer, the outcome and prognosis of patients remain poor. Lung cancer is the leading cause of cancer-related deaths worldwide, with 1.8 million new cases being diagnosed each year. Precision medicine based on genetic alterations is considered a new strategy of lung cancer treatment that requires highly specific biomarkers for precision diagnosis and treatment. Fibrinogen-like protein 2 (FGL2) plays important roles in both innate and adaptive immunity. However, the diagnostic value of FGL2 in lung cancer is largely unknown. In this study, we systematically investigated the expression profile and potential functions of FGL2 in lung adenocarcinoma. We used the TCGA and Oncomine datasets to compare the FGL2 expression levels between lung adenocarcinoma and adjacent normal tissues. We utilized the GEPIA, PrognoScan and Kaplan-Meier plotter databases to analyze the relationship between FGL2 expression and the survival of lung adenocarcinoma patients. Then, we investigated the potential roles of FGL2 in lung adenocarcinoma with the TIMER database and functional enrichment analyses. We found that FGL2 expression was significantly lower in lung adenocarcinoma tissue compared with adjacent normal tissue. A high expression level of FGL2 was correlated with better prognostic outcomes of lung adenocarcinoma patients, including overall survival and progression-free survival. FGL2 was positively correlated with the infiltration of immune cells, including dendritic cells, CD8 + T cells, macrophages, B cells, and CD4 + T cells, in lung adenocarcinoma. Functional enrichment analyses also showed that a high expression level of FGL2 was positively correlated with enhanced T cell activities, especially CD8 + T cell activation. Thus, we propose that high FGL2 expression, which is positively associated with enhanced antitumor activities mediated by T cells, is a beneficial marker for lung adenocarcinoma treatment outcomes. . 2020. FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma. PeerJ 8:e8654 http://doi.BE, Golub TR, Sugarbaker DJ, Meyerson M. 2001. Classification of human lung carcinomas by mRNA expression profiling reveals distinct adenocarcinoma subclasses. Said JW, McBride WH, Kabbinavar FF, Ribas A, Pantuck AJ, Belldegrun AS, Riss J. 2013. Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: efficacy, safety, and activity of Ad-GM·CAIX in immunocompetent mouse models. Journal T. 2013. Soluble FGL2 induced by tumor necrosis factor-α and interferon-γ in CD4+ T cells through MAPK pathway in human renal allograft acute rejection.

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Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation

Cited by 24 publications

References 108 publications

Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Soluble fibrinogen-like protein 2 in condyloma acuminatum lesions

Fibrinogen-Like Protein 2 (FGL2) is a Novel Biomarker for Clinical Prediction of Human Breast Cancer

FGL2 is positively correlated with enhanced antitumor responses mediated by T cells in lung adenocarcinoma

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