Soluble ICAM‐1 as a regulator of nasal allergic reaction under natural allergen provocation

Kato, Masashi; Hattori, Taku; Kitamura, Mayumi; Beppu, Reiko; Yanagita, Noriyuki; Nakashima, Izumi

doi:10.1111/j.1365-2222.1995.tb00012.x

Cited by 31 publications

(28 citation statements)

References 16 publications

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“…To circumvent the dilution, the raw data of total IgE and IgG were normalized with urea concentrations, which were assumed to diffuse freely between tissue and secretions (10). After normalization, the total IgE amounts in the NLF ranged from undetectable to 45.8 (median 1.67) IU/ml, while those in serum were from 6.7 to 1,125 (median 88.6) IU/ml.…”

Section: Resultsmentioning

confidence: 99%

“…Patients were precluded if they had received topical or systemic glucocorticoid therapy within the preceding 3 months or had suffered from upper respiratory infections within 1 month. The nasal lavage was performed by instilling 5 ml of sterile saline to each nostril according to the previous report (10). The serum was drawn subsequently, and the nasal lavage fluids and sera were separated from cells by a centrifugation at 1,500ϫg to be stored frozen until analysis.…”

Section: Methodsmentioning

confidence: 99%

“…The concentrations of urea were measured by the ureaseindophenol method using the kit from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). The concentrations of immunoglobulins in NLF were normalized with urea concentrations, assuming that urea diffuses freely from serum to nasal secretions (10).…”

Section: ϫ6mentioning

confidence: 99%

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A Quantitative Analysis of Cedar Pollen‐Specific Immunoglobulins in Nasal Lavage Supported the Local Production of Specific IgE, Not of Specific IgG

Yoshida

Usui

Kusumi

et al. 2005

Microbiology and Immunology

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Many studies have proved the relevance of local immune responses, rather than systemic immunity, to the pathogenesis of allergic rhinitis. Indeed, allergen‐specific B lymphocyte undergoes class switching to IgE in situ. However, the relative contribution of in situ production to the amount in serum is still ambiguous. Here, a quantitative comparison of the local concentration of allergen‐specific IgE with the systemic concentration was explored for the estimation. Among seasonal rhinitis patients, total and Japanese cedar pollen (JCP)‐specific IgE, IgA and IgG antibodies were quantified in nasal lavage fluid (NLF) and serum with the time‐resolved fluorescence immunosorbent assay. Although the total amounts of IgE and IgG classes in the NLF, which were apparently passive discharge from the mucosal tissue, were smaller and variable, the relative proportions of JCP‐specific antibodies could be quantitatively compared between NLF and serum or between subjects. The proportions of specific IgE in the NLF were remarkably higher than in serum (average 13.2‐fold) in most subjects, which strongly supported the predominant in situ production of the specific IgE and subsequent dilutions in the systemic circulations. Similar but smaller values were obtained for IgA (average 3.7‐fold). In contrast, the specific proportions of IgG in the NLF were surprisingly consistent with serum (average 1.0‐fold), suggesting that the specific IgG was mostly produced in the downstream lymphoid organs. The local productions of specific IgE would encourage the topical therapies and the usage of the NLF for the diagnosis of allergic rhinitis.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Quantitative Analysis of Cedar Pollen‐Specific Immunoglobulins in Nasal Lavage Supported the Local Production of Specific IgE, Not of Specific IgG

Yoshida

Usui

Kusumi

et al. 2005

Microbiology and Immunology

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“…During the past several years, serum sICAM‐1 levels have been studied in allergic conditions, such as atopic dermatitis and asthma 7‐13 . However, serum sICAM‐1 levels in perennial allergic rhinitis remain to be investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Serum levels of sICAM‐1 were determined in asthma, 7‐10 seasonal allergic rhinitis, 11 and atopic dermatitis, 12,13 but not in perennial allergic rhinitis. If the levels of sICAM‐1 vary between patients with perennial allergic rhinitis and normal controls, this variance would be very useful to assess or monitor the state of this disease underlying the inflammation responsible for nasal symptoms.…”

Section: Introductionmentioning

confidence: 99%

Soluble Intercellular Adhesion Molecule‐1 Level in Sera Is Elevated in Perennial Allergic Rhinitis

et al. 1997

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Soluble intercellular adhesion molecule-1 (sICAM-1) in sera was measured in some allergic disorders, but serum sICAM-1 levels in perennial allergic rhinitis remain to be determined. Our study was aimed at elucidating whether the serum sICAM-1 levels in patients with perennial allergic rhinitis are different from those in nonatopic healthy volunteers and whether immunotherapy can modulate sICAM-1 levels. Serum sICAM-1 was determined in 20 nonallergic volunteers and 137 patients with perennial allergic rhinitis by a sandwich enzyme-linked immunosorbent assay. Our study demonstrated that the level of sICAM-1 in untreated patients is significantly elevated, as compared with nonatopic subjects. Immunotherapy could decrease sICAM-1 in perennial allergic rhinitis, but this suppressive effect became apparent only after many years of immunotherapy. In patients on immunotherapy, a close correlation was observed between sICAM-1 and nasal symptom scores. To take these lines of evidence together, a decrease in sICAM-1 might be related to the working mechanism of immunotherapy, and serum sICAM-1 could be used to monitor the effect of immunotherapy.

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Clinical Role of Soluble Adhesion Molecules During Immunotherapy for Perennial Allergic Rhinitis

Ōhashi

Nakai²,

Tanaka³

et al. 1998

Arch Otolaryngol Head Neck Surg

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Soluble ICAM‐1 as a regulator of nasal allergic reaction under natural allergen provocation

Abstract: We demonstrate systemic and local upregulation of sICAM-1 and systemic downregulation of LFA-1 positive lymphocytes in patients with seasonal allergic rhinitis under natural allergen provocation, suggesting that sICAM-1 plays a role in regulating seasonal allergic inflammation.

Cited by 31 publications

References 16 publications

A Quantitative Analysis of Cedar Pollen‐Specific Immunoglobulins in Nasal Lavage Supported the Local Production of Specific IgE, Not of Specific IgG

A Quantitative Analysis of Cedar Pollen‐Specific Immunoglobulins in Nasal Lavage Supported the Local Production of Specific IgE, Not of Specific IgG

Soluble Intercellular Adhesion Molecule‐1 Level in Sera Is Elevated in Perennial Allergic Rhinitis

Clinical Role of Soluble Adhesion Molecules During Immunotherapy for Perennial Allergic Rhinitis

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