Soluble intercellular cell adhesion molecule-1 and L-selectin plasma concentrations and response to surfactant in preterm infants

Abstract

In preterm infants with respiratory distress, a poor response to surfactant within 6 hrs of administration is associated with elevated circulating ICAM-1 concentrations at 24 hrs of age. Low plasma L-selectin at 24 hrs of age predicts prolonged requirement for supplemental oxygen.

Plasma proteome changes in cord blood samples from preterm infants

“…L-Selectin is a cell surface adhesion molecule but can simultaneously be released as a soluble isoform, which reduces leukocyte adhesion to the endothelium, thereby ameliorating immune cell infiltration during inflammation (24). Of note, low L-selectin plasma level13hr have been associated with a poor responsiveness to surfactant therapy in preterm infants with respiratory distress and can serve as a predictive marker of a prolonged requirement for supplemental oxygen (25).…”

Prospective plasma proteome changes in preterm infants with different gestational ages

“…24 Of note, low L-selectin plasma level have been associated with a poor responsiveness to surfactant therapy in preterm infants with respiratory distress and can serve as a predictive marker of a prolonged requirement for supplemental oxygen. 25 According to our results, L-selectin induction was correlated with preterm gestation age ( Table 2). Contrarily to the beneficial induction of ORM, SAP, PI16, and Lselectin in 36-PMA collected samples, we found that the concentration of leucine-rich alpha-2-glycoprotein (LRG1) increased over time (Table 2).…”

Selectin polymorphisms and perinatal morbidity in low‐birthweight infants

“…High E‐selectin levels in cord and peripheral blood [22, 23] have been shown to be predictive of BPD. Low plasma L‐selectin levels during the early postnatal period have been shown to be predictive of length of supplemental oxygen requirement [24] and risk of BPD [25, 26]. Dexamethasone treatment may also affect BPD risk through its impact on L‐selectin expression [27].…”