Soluble ST2 – as a biomarker, a tool for risk stratification and therapeutic target in patients with chronic heart failure

Камардинов, Д.Х.; Songurov, R. N.; Иошина, В.И.; Buziashvili, Yu. I.

doi:10.18087/cardio.2020.2.n816

Cited by 10 publications

(5 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Определение полиморфизма -1171 5A/6A гена ММР3 может быть рекомендовано для оценки раннего прогноза развития и тяжести течения ХСН. В нашем исследовании отмечалось достоверное преобладание гетерозиготного генотипа (6а/5а) полиморфизма гена MMP3 по сравнению с контрольной группой (66,7% vs 12,5%, р=0,023), что можно рассматривать в качестве предиктора развития ХСН у пациентов с ДМ ИГ c целью ранней диагностики и профилактики [6].…”

Section: Discussionunclassified

Predictors of heart failure in patients with cardiomyopathies of various origins

Kuznetsova,

Nikulina,

Matyushin

et al. 2023

Russ J Cardiol

View full text Add to dashboard Cite

Aim. To identify predictors of heart failure in patients with dilated cardiomyopathy (DCM) and ischemic myocardial dilatation (IMD).Material and methods. In total, we examined 221 patients with cardiomyopathies: DCM and IMD. The mean age of the patients was 55,30±9,69 years (minimum — 20 years, maximum — 77 years). From the total number of patients, a group of patients with DCM (idiopathic origin) (group 1) was identified in the amount of 111 people, of which 99 were men (89,2%) and 12 women (10,8%). The mean age of patients with DCM was 51,73±9,74 years, for men — 51,00±8,96 years, for women — 57,75±3,71 years. The median age in DCM patients was 53,00 [48,00; 58,00], for men — 53,00 [46,00; 57,00], in women — 59,50 [49,00; 68,75]. Patients with IMD (ischemic origin) consisted of 110 people (group 2), of which 100 were men (91,5%) and 10 women (8,5%). The mean age of patients with IMD was 58,68±8,38 years, for men — 58,29±8,46 years, for women — 62,90±6,29 years. The median age in patients with IMD was 58,00 [53,50; 63,50], in men — 58,00 [52,00; 63,00], in women — 61,50 [59,25; 66,00]. Biological material (venous blood) was taken from all patients for molecular genetic analysis. To isolate the DNA structure, the phenol-chloroform extraction was used. Using the polymerase chain reaction, genotyping of gene polymorphisms was carried out, followed by analysis of restriction fragment length polymorphisms.Results. To assess the left ventricular systolic function, the ejection fraction was assessed. Heart failure and its severity are most often associated with a decrease in left ventricular (LV) systolic function. In our study, in the group of patients with DCM, the mean LV ejection fraction (EF) was 25,105±6,76, while in IMD group — 20,255±4,49 (p=0,0001). This confirms that these two groups have severe heart failure associated with impaired LV systolic function — a decrease in EF <30%. In patients with NYHA class III heart failure with IMD, there was a significant predominance of the heterozygous genotype (6a/5a) of the MMP3 gene polymorphism compared to the control group (66,7% vs 12,5%, p=0,023).Conclusion. The heterozygous genotype of the MMP3 gene polymorphism can be considered as a predictor of the development of HF in patients with IMD for the purpose of early diagnosis and prevention of heart failure. In the group of patients with DCM, no differences were found during a comparative analysis with gene polymorphism.

show abstract

Section: Discussionunclassified

Predictors of heart failure in patients with cardiomyopathies of various origins

Kuznetsova,

Nikulina,

Matyushin

et al. 2023

Russ J Cardiol

View full text Add to dashboard Cite

show abstract

“…Причины подъема натрийуретических пептидов [12,21,22] Table 2. Causes of the increased content of natriuretic peptide [12,21,22] Кардиальные / Cardiac [25]. С-тип НУП может преимущественно рассматриваться в качестве маркера дисфункции эндотелия [12].…”

Section: натрийуретические пептиды в амбулаторной практикеunclassified

“…Однако, широкая вариабельность значений НУП, обусловленная зависимостью от пола, возраста и сопутствующей патологии, является недостатком данной группы биомаркеров. В настоящее время наблюдается высокий интерес к изучению новых маркеров ХСН, таких как растворимый ST2 рецептор (растворимый стимулирующий фактор роста, экспрессируемый геном 2, soluble suppression of tumorigenesis-2, sST2), копептин (copeptin), галектин-3 (galectin-3) [12,22].…”

Section: некардиальные / Noncardiacunclassified

“…Растворимый ST2 рецептор -биомаркер «механического» миокардиального стресса, принадлежащий к семейству рецепторов интерлейкина-1, экспрессирующийся в кардиомиоцитах, а также клетках эндотелия сосудов и пневмоцитах II типа [12,22,28,29].…”

Section: растворимый St2 рецепторunclassified

See 1 more Smart Citation

The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

Ларина

Лунев

2021

Arhivʺ vnutrennej mediciny

View full text Add to dashboard Cite

The search for reliable algorithms for diagnosing heart failure with preserved left ventricular ejection fraction (LVEF) in elderly patients is an urgent problem due to the low specificity of clinical manifestations and the peculiarities of involutive processes occurring in the human body. As an alternative diagnostic approach, it is possible to determine in the blood laboratory biochemical markers — a promising method of diagnosis, prognosis and control of the effectiveness of treatment. The article examines the significance of myocardial stress markers (brain natriuretic peptide, N-terminal brain natriuretic peptide, median fragment of atrial natriuretic peptide); «mechanical» myocardial stress (soluble stimulating growth factor expressed by gene 2 — sST2), copeptin, galectin-3 in patients with heart failure and preserved LVEF, including older persons, as well as the possibility of their use in outpatient practice to predict the course of heart failure. The contribution of the multimarker model for a comprehensive assessment of prognosis is discussed, taking into account both the «hemodynamic» side of myocardial stress (pressure or volume overload, markers — natriuretic peptides), and «mechanical» (fibrosis / hypertrophy / heart remodeling, marker — sST2) myocardial changes.

show abstract

“…An inflammatory concept has been formulated, which is based on the persistent inflammation present at the early stages of CHF, as well as at later stages, when CHF is verified [6]. Recently, the study of inflammation markers and their role in cardioprotective mechanisms, as well as growth factors and cytokines as prognostically relevant biomarkers of developing heart failure deserved particular interest [4,5]. It is known that imbalance of pro-and anti-inflammatory cytokines significantly contributes to development and progression of CHF, but the results of experimental and exploratory clinical studies have not led to the emergence of a single effective anti-inflammatory strategy in CHF syndrome [7].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Changes in Cardiovascular Risk Biomarkers and Cytokines of Myocarditis-Free Patients With Decompensated Heart Failure and Ischemic Systolic Dysfunction

et al. 2021

View full text Add to dashboard Cite

The development and progression of heart failure is associated with a variety of pathophysiological mechanisms, of particular interest is the study of the inflammatory response as a fundamental link in the pathogenesis of CHF and its main component – decompensation. An open, non-randomized, prospective study was carried out to evaluate the clinical and morphological features of subclinical inflammation in patients with acute decompensation of ischemic chronic heart failure with a reduced ejection fraction. The study included 25 patients with decompensated ischemic CHF with left ventricular ejection fraction < 40% aged 35 to 75 years (60.12±9.3 y. o.). In this study the dynamics of the serum content of C-reactive protein (CRP), N-terminal fragment of the brain natriuretic peptide precursor protein (NT-proBNP), soluble ST2(sST2), insulin-like growth factor-1 receptor (IGF-1R), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNFα) was performed by multiplex immunoassay using the FLEXMAP 3D. All studied patients were divided into two groups depending on the diagnosed myocarditis: patients with no signs of myocarditis and patients with myocarditis. It was found that in the group of patients with diagnosed myocarditis there was an increased content of CRP, IGF-1R, IL-6 and IL-10, TNFα compared to the group of patients without myocarditis. The median concentrations of the NT-proBNP and sST2 in both groups did not differ. At the follow-up visit a year later, there was a decrease in the content of CRP, NT-proBNP, IL-6 in both groups. In the group of patients with myocarditis, an increase in the content of sST2, IGF-1R, IL-10 was observed. Thus, the study carried out in dynamics revealed significant differences in the degree of changes in the serum activity of pro- and anti-inflammatory cytokines and biomarkers of cardiovascular risk in patients with decompensated heart failure with systolic dysfunction with diagnosed myocarditis and in its absence.

show abstract

Soluble ST2 – as a biomarker, a tool for risk stratification and therapeutic target in patients with chronic heart failure

Cited by 10 publications

References 74 publications

Predictors of heart failure in patients with cardiomyopathies of various origins

Predictors of heart failure in patients with cardiomyopathies of various origins

The Value of Biomarkers in the Diagnosis and Prognosis of Heart Failure in Older Age

Dynamic Changes in Cardiovascular Risk Biomarkers and Cytokines of Myocarditis-Free Patients With Decompensated Heart Failure and Ischemic Systolic Dysfunction

Contact Info

Product

Resources

About