Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Haag, Patricia; Sharma, Himanshu; Rauh, Manfred; Zimmermann, Theodor; Vuorinen, Tytti; Papadopoulos, Nikolaos G.; Weiss, Scott T.; Finotto, Susetta

doi:10.1111/cei.13135

Cited by 19 publications

(33 citation statements)

References 55 publications

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“…Different hypotheses could explain this paradox. For example, it has been recently demonstrated that the production of the soluble decoy receptor sST2 is enhanced by vitamin D ( 94 ). Since sST2 neutralizes the effect of IL-33, it is considered an anti-inflammatory factor in conditions in which IL-33 takes place in the driving inflammatory processes, such as asthma and Pso, and IL-33 neutralization may represent a novel therapeutic approach in these diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Its receptor complex consists of a primary receptor, ST2, and an accessory IL-1 receptor protein. The ST2 receptor exists in two different forms: a transmembrane isoform acts as a cellular receptor, whereas a soluble form (sST2) plays the role of decoy receptor inhibiting IL-33 activity ( 93 , 94 ). Interestingly, the IL-33/ST2 axis is involved in both Th2 and Th1/Th17 responses ( 88 ) as well as in the activation of Treg and natural killer (NKT) cells, B and NK lymphocytes, neutrophils, and macrophages ( 91 , 95 – 98 ).…”

Section: The Role Of Il-33mentioning

confidence: 99%

“…Both vitamin D deficiency and increased circulating sST2 decoy receptor in Pso negatively impact the bone, favoring the production of Th1 rather than Th2 cytokines, suppressing the development of Treg cells and the production of regulatory and anti-inflammatory cytokines, thus promoting osteoclastogenesis and bone resorption ( 88 , 94 ). The frequent of onset of OP during Pso could also be conditioned by the effective variability of effects of IL-33 on bone remodeling, which are dependent on a wide range of other factors (inflammatory microenvironment, influence of other cytokines, hormones, and vitamins) ( 9 ).…”

Section: The Paradox Of the Vitamin D And Il-33 Relationship In Pso-amentioning

confidence: 99%

Section: The Role Of Il-33mentioning

confidence: 99%

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IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

et al. 2021

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Patients with psoriasis (Pso) and, in particular, psoriatic arthritis (PsoA) have an increased risk of developing osteoporosis (OP). It has been shown that OP is among the more common pathologies associated with Pso, mainly due to the well-known osteopenizing conditions coexisting in these patients. Pso and OP share common risk factors, such as vitamin D deficiency and chronic inflammation. Interestingly, the interleukin (IL)-33/ST2 axis, together with vitamin D, is closely related to both Pso and OP. Vitamin D and the IL-33/ST2 signaling pathways are closely involved in bone remodeling, as well as in skin barrier pathophysiology. The production of anti-osteoclastogenic cytokines, e.g., IL-4 and IL-10, is promoted by IL-33 and vitamin D, which are stimulators of both regulatory and Th2 cells. IL-33, together with other Th2 cytokines, shifts osteoclast precursor differentiation towards macrophage and dendritic cells and inhibits receptor activator of nuclear factor kappa-B ligand (RANKL)-induced osteoclastogenesis by regulating the expression of anti-osteoclastic genes. However, while the vitamin D protective functions in OP and Pso have been definitively ascertained, the overall effect of IL-33 on bone and skin homeostasis, because of its pleiotropic action, is still controversial. Emerging evidence suggests a functional link between vitamin D and the IL-33/ST2 axis, which acts through hormonal influences and immune-mediated effects, as well as cellular and metabolic functions. Based on the actions of vitamin D and IL-33 in Pso and OP, here, we hypothesize the role of their crosstalk in the pathogenesis of both these pathologies.

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Section: Discussionmentioning

confidence: 99%

Section: The Role Of Il-33mentioning

confidence: 99%

Section: The Paradox Of the Vitamin D And Il-33 Relationship In Pso-amentioning

confidence: 99%

Section: The Role Of Il-33mentioning

confidence: 99%

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IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

et al. 2021

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“…Notably, IL-33 expression is up-regulated in the bronchial mucosa of asthmatic patients related to disease severity [ 16 , 17 ]. Its receptor ST2 expression is increased in endobronchial specimens and blood cells of severe asthmatic and associated with multiple indicators of Th2 inflammation [ 18 , 19 ]. Moreover, IL-33 polymorphisms influence the susceptibility to asthma.…”

Section: The Role Of Il-33 In Allergic Diseasesmentioning

confidence: 99%

Interleukin-33: Its Emerging Role in Allergic Diseases

et al. 2018

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Allergic diseases, which include asthma, allergic rhinitis (AR), chronic rhinosinusitis (CRS), atopic dermatitis (AD), food allergy (FA), allergic keratoconjunctivitis, seriously affect the quality of life of people all over the world. Recently, interleukin-33 (IL-33) has been found to play an important role in these refractory disorders, mainly by inducing T helper (Th) 2 immune responses. This article reviews the mobilization and biological function of IL-33 in allergic disorders, providing novel insights for addressing these hypersensitive conditions.

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Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack

Lejeune

Deschildre

Rouzic

et al. 2020

Biochemical Pharmacology

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Exacerbations are a main characteristic of asthma. In childhood, the risk is increasing with severity. Exacerbations are a strong phenotypic marker, particularly of severe and therapy-resistant asthma. These earlylife events may influence the evolution and be involved in lung function decline.In children, asthma attacks are facilitated by exposure to allergens and pollutants, but are mainly triggered by microbial agents. Multiple studies have assessed immune responses to viruses, and to a lesser extend bacteria, during asthma exacerbation. Research has identified impairment of innate immune responses in children, related to altered pathogen recognition, interferon release, or anti-viral response. Influence of this host-microbiota dialog on the adaptive immune response may be crucial, leading to the development of biased T helper (Th)2 inflammation. These dynamic interactions may impact the presentations of asthma attacks, and have long-term consequences.The aim of this review is to synthesize studies exploring immune mechanisms impairment against viruses and bacteria promoting asthma attacks in children. The potential influence of the nature of infectious agents and/or preexisting microbiota on the development of exacerbation is also addressed. We then discuss our understanding of how these diverse host-microbiota interactions in children may account for the heterogeneity of endotypes and clinical presentations. Finally, improving the knowledge of the pathophysiological processes induced by infections has led to offer new opportunities for the development of preventive or curative therapeutics for acute asthma. A better definition of asthma endotypes associated with precision medicine might lead to substantial progress in the management of severe childhood asthma.

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Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children

Cited by 19 publications

References 55 publications

IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

IL-33/Vitamin D Crosstalk in Psoriasis-Associated Osteoporosis

Interleukin-33: Its Emerging Role in Allergic Diseases

Childhood asthma heterogeneity at the era of precision medicine: Modulating the immune response or the microbiota for the management of asthma attack

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