Soluble starch formulated nanocomposite increases water solubility and stability of curcumin

Li, Jinglei; Shin, Gye Hwa; Lee, Il Woo; Chen, Xiguang; Park, Hyun Jin

doi:10.1016/j.foodhyd.2015.11.024

Cited by 164 publications

(89 citation statements)

References 40 publications

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“…Sendo de natureza hidrofóbica, a curcumina é insolúvel em soluções aquosas, mas solúvel em solventes orgânicos tais como dimetilsulfóxido (DMSO), acetona, metanol e etanol, sendo que o máximo de absorção (λ max ) de curcumina ocorre em metanol por volta de 430 nm. Para utilizar as atividades farmacêuticas da curcumina e superar a sua fraca disponibilidade no local de ação no corpo, outras formas de sua utilização, têm sido desenvolvidas tais como; a utilização de micelas, complexos fosfolipídios, ciclodextrina, lipossomas, nanopartículas, macromoléculas, hidrogéis [16,17,18].…”

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Avaliação do método de obtenção de scaffolds quitosana/curcumina sobre a estrutura, morfologia e propriedades térmicas

et al. 2016

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RESUMOPesquisas tem sido realizada com objetivo de combinar propriedades dos materiais com a finalidade de melhorar o processo de regeneração. Portanto scaffolds como sistemas de liberação controlada de fármacos tem sido estudado a fim de proporcionar o crescimento do tecido ao mesmo tempo que a região esteja sendo tratada. Diante disso, essa pesquisa tem como objetivo desenvolver scaffolds de quitosana e avaliar a inserção do fármaco curcumina por meio dos métodos de reação de solução e adsorção visando obter um sistema quitosana/curcumina para liberação controlada do fármaco. Os scaffolds foram produzidos pelo método de agregação de esferas, onde as esferas foram inicialmente obtidas a partir do gotejamento da solução de quitosana e quitosana/curcumina em solução de sulfato de sódio (5%) e posteriormente agregadas pela solução de gelatina (5%). Foram realizadas as caracterizações de espectroscopia no infravermelho com transformada de Fourier (FTIR), microscopia ótica (MO), microscopia eletrônica de varredura (MEV) e calorimetria exploratória diferencial (DSC). Por FTIR sugeriu-se a interação da quitosana com a curcumina. A partir das avaliações morfológicas por MO e MEV foi possível identificar o fármaco no interior das estruturas pelos dois métodos utilizado. E por DSC observou-se para amostra de quitosana/curcumina o desaparecimento do pico de fusão característico da curcumina, indicando assim que a curcumina foi encapsulada na quitosana no estado amorfo, o que provavelmente ocasionará uma liberação mais lenta do fármaco. Dessa forma, constatou-se que as estruturas obtidas são promissoras para o estudo de liberação controlada de fármaco.Palavras-chave: Curcumina, Quitosana, Scaffolds. ____________________________________________________________________________________ ABSTRACTResearches have been conducted in order to match material properties to improve the regeneration process. Thereby, scaffolds as controlled drug delivery systems have been studied in order to enhance the obtained structure by providing tissue growth while the region is being treated. Thus, this research aims to develop scaffolds of chitosan, and avaluatinh the insertion of curcumin drug by the methods of , solutions reaction and adsorption, aiming at obtaining a chitosan/curcumin for controlled drug release system. The scaffolds were produced by beads aggregation method, in which the beads were originally obtained from the dropping of chitosan solution and chitosan / curcumin in sodium sulphate solution (5%) and then attached by the gelatin solution (5%). The following characterizations were performed: Fourier Transform Infrared Spectroscopy (FTIR), Optical Microscopy (OM), Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetry (DSC). By FTIR analysis, it was possible to verify the likely interaction of chitosan with curcumin. From the morphological analysis by OM and SEM it was possible to identify the drug inside the structures by both methods. DSC analysis showed the total disappearance of the characteristic melting ...

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Avaliação do método de obtenção de scaffolds quitosana/curcumina sobre a estrutura, morfologia e propriedades térmicas

et al. 2016

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“…We have reported that native and acetylated banana starch nanoparticles loaded with curcumin have lower release values in SGF due to the banana starch resistance to acid hydrolysis when compared with other types of starches. 23,43 Our results suggest that BC-CABSNps are more susceptible to interacting with intestinal fluid, allowing higher release rates than their native starch counterpart and indicating that cross-linked banana starch nanoparticles can be used as BC molecule carrier for specific intestinal release. Incomplete BC release was observed in SGF and SIF, indicating that a small amount of BC remains trapped in the starch matrix.…”

Section: Bc Release In Gastric Conditionsmentioning

confidence: 83%

Citric‐acid modified banana starch nanoparticles as a novel vehicle for β‐carotene delivery

2019

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BACKGROUND Starch nanoparticles have become among the most interesting nanovehicles for drug delivery because of their relatively easy synthesis, biocompatibility, and numerous botanical sources. Starch nanoparticles obtained from green bananas were cross‐linked with citric acid and loaded with β‐carotene. RESULTS Mean particle size, encapsulation efficiency, and β‐carotene release in simulated gastric and intestinal fluids and food simulants were studied. Cross‐linked nanoparticles showed higher loading efficiency and encapsulation capacity, indicating that they can accommodate more molecules than their unmodified counterparts, while mathematical models showed a diffusion of released β‐carotene into food simulant media. CONCLUSIONS Cross‐linked nanoparticles showed more controlled release under gastric conditions, mainly in the simulated intestinal fluid, indicating that they are suitable as vehicles for intestine‐specific targeting. This controlled released was also observed in food simulants, with lower release values in the more aqueous simulants. © 2019 Society of Chemical Industry

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“…In vitro release study was performed in acidic solution 0.1 N HCl (pH 1.2) and at pH 6.8 phosphate buffer by some modifications in the dialysis bag method as described by Shah et al 21 Dialysis membrane of 12,000-14,000 molecular weight cut-off (Fisher brand) was used for the experiment. Glycerine in the membrane was washed with the warm Milli-Q water thrice and five ml of LCNs and ALG-LCNs (5mg) were suspended in dissolution medium.…”

Section: In Vitro Release Profile Of the Curcumin From Lcns And Alg-lcnsmentioning

confidence: 99%

Alginate-chitosan Coated Lecithin Core Shell Nanoparticles for Curcumin: Effect of Surface Charge on Release Properties and Biological Activities

Pathak¹,

Amrutanand²,

Agrawal³

2017

IJPER

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Alginate-chitosan coated lecithin nanoparticles loaded with Curcumin have been prepared by layer deposition of alginate on lecithin/chitosan nanoparticles and were characterized. The prepared nanoparticles were physicochemically characterized to ensure alginate coating. The encapsulation efficiency and loading of the active nutraceutical were assessed using spectrophotometric measurements. The biological activities of the prepared nanoparticles were assessed by membrane stabilization effect of the nanoparticles on goat RBCs under hypotonic and thermally induced conditions. The biocompatibility of blank nanocarriers was assessed by performing In vitro cytotoxicity studies on HEK cell lines. The release profile of curcumin from alginate uncoated and alginate coated nanoparticles were compared to analyze effect of surface charge of the particles on studied bioactivities. It was found that uniformly sized alginate coated nanoparticles were formed with negative surface charge. It was also observed that there was no significant difference due to surface charge of the nanoparticles on cytotoxicity and membrane stabilization activity. However alginate coating offered more controlled release of the curcumin in acidic conditions suggesting that these alginate coating imparted enteric coating character.

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Soluble starch formulated nanocomposite increases water solubility and stability of curcumin

Cited by 164 publications

References 40 publications

Avaliação do método de obtenção de scaffolds quitosana/curcumina sobre a estrutura, morfologia e propriedades térmicas

Avaliação do método de obtenção de scaffolds quitosana/curcumina sobre a estrutura, morfologia e propriedades térmicas

Citric‐acid modified banana starch nanoparticles as a novel vehicle for β‐carotene delivery

Alginate-chitosan Coated Lecithin Core Shell Nanoparticles for Curcumin: Effect of Surface Charge on Release Properties and Biological Activities

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