The Industrial Revolution 4.0 is having a substantial impact on countries in many fields such as industry structure, human resource needs, production management systems. Transportation is a high-community industry, so it will also be strongly affected by this industrial revolution. The achievements of Industry 4.0 can reshape the nation's transportation systems. That poses challenges for transportation managers to change the operating model as well as the transport-related policies. Building and developing intelligent transport systems (ITS) is attracting considerable attention, research, and investment to serve the development of transportation systems in the world as well as in Vietnam. Vietnam is gradually building Intelligent Governments, Intelligent Cities, and the Intelligent Transportation system will be an essential part of that development and entering the stage of access to the 4.0 industrial revolution, building a smart city applying 4.0 technology to bring convenience, friendliness, and safety to people in each city. As a step ahead, the Transport industry gradually realizes its dream of developing intelligent transportation in developed cities like Hanoi and Ho Chi Minh City. The paper presents an overview of the impact of Industry 4.0 on key aspects of the transport sector in general and ITS development strategy in Vietnam. On that basis, state-of-the-art technologies-technology 4.0 are proposed to meet the demands of intelligent transportation development. The paper will show that 4.0 technology is the key to the development of ITS in Vietnam.