Solvent effect on fluid characteristics of doxycycline hyclate-loaded bleached shellac in situ-forming gel and -microparticle formulations

Phaechamud, Thawatchai; Praphanwittaya, Pitsiree; Laotaweesub, Kunchalee

doi:10.1007/s40005-017-0338-4

Cited by 21 publications

(10 citation statements)

References 29 publications

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“…The DHRL0 to DHRL5 presented no statistically significant difference in viscosity results ( p ≥ 0.05). After drug incorporation, less solvent in the system made the preparation more viscous and increased viscosity [ 38 ]. The formulation viscosity was increased as the amount of LO increased owing to the replacement of less viscous DMSO with more viscous LO.…”

Section: Resultsmentioning

confidence: 99%

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Khaing

Mahadlek

Okonogi

et al. 2022

Gels

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Localized intra-periodontal pocket drug delivery using an injectable in situ forming gel is an effective periodontitis treatment. The aqueous insoluble property of rosin is suitable for preparing a solvent exchange-induced in situ forming gel. This study aims to investigate the role of incorporating lime peel oil (LO) on the physicochemical properties of injectable in situ forming gels based on rosin loaded with 5% w/w doxycycline hyclate (DH) in dimethyl sulfoxide (DMSO) and N-methyl pyrrolidone (NMP). Their gel formation, viscosity, injectability, mechanical properties, wettability, drug release, and antimicrobial activities were evaluated. The presence of LO slowed gel formation due to the loose precipitate formation of gel with a high LO content. The viscosity and injectability were slightly increased with higher LO content for the DH-loaded rosin-based in situ forming gel. The addition of 10% LO lowered gel hardness with higher adhesion. LO incorporation promoted a higher drug release pattern than the no oil-added formulation over 10 days and the gel formation rate related to burst drug release. The drug release kinetics followed the non-Fickian diffusion mechanism for oil-added formulations. LO exhibited high antimicrobial activity against Porphyromonas gingivalis and Staphylococcus aureus. The DH-loaded rosin in situ forming gel with an addition of LO (0, 2.5, 5, and 10% w/w) inhibited all tested microorganisms. Adding 10% LO to rosin-based in situ forming gel improved the antimicrobial activities, especially for the P. gingivalis and S. aureus. As a result, the study demonstrates the possibility of using an LO amount of less than 10% loading into a rosin-based in situ forming gel for efficient periodontitis treatment.

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Section: Resultsmentioning

confidence: 99%

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Khaing

Mahadlek

Okonogi

et al. 2022

Gels

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“…The lacquers are synthetic polymeric materials (epoxy [1][2][3][4][5], acrylic [6][7][8], ester [9,10], polyurethane [11] etc.) or natural (plant extracts such as Urushi [12,13], insect secretion -Shellac [14,15]).…”

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confidence: 99%

Comparative Studies on the Electrical and Mechanical Behavior of Some Soldering and / or Impregnation Lacquers

Bors¹,

Lingvay²,

Caramitu³

et al. 2019

Mat.Plast.

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In order to evaluate the behavior in various electrical applications, the main mechanical and electrical characteristics of three different varieties of specifically chosen lacquers - based on alkyl-epoxy-melamine copolymer, the epoxy polymer and polyurethane were compared. From the mechanical determinations, it was found that at ambient temperature the polyurethane lacquer bending resistance was approximately equal to that of the epoxy lacquer and about 6.5 times higher that of the alkyl-epoxy-melamine copolymer. It has also been shown that at bending force of less than 150 Nm the investigated polyurethane lacquer has relatively large deformations of 0.4 mm / kN, which indicates a high capacity to take over relatively high deformations of the metal support (due to thermal expansion from various applications) without significant increasing mechanical stress. The recorded values for the alkyl-epoxy-melamine-based copolymer lacquer and the pure epoxy lacquer are 0.11 mm / kN and 0.03 mm / kN respectively. Determinations by dielectric spectroscopy have shown that at frequencies below 250 Hz the dielectric losses tgd for the epoxy and polyurethane lacquers are approximately equal and are about 2.9 times lower than for the alkyl-epoxy-melamine copolymer lacquer. It was also found that at frequencies higher than 250 Hz the investigated materials behave differently, respectively at the frequency increase up to 10 kHz, the dielectric loss tgd of the polyurethane lacquer remains constant at about 0.0045 in contrast to the epoxide lacquer at which the dielectric loss tgd increases monotone to 0.0095 at 10 kHz, respectively of the alkyl-epoxy-melamine copolymer at which the dielectric loss tgd is approximately constant 0.012 in the 250 Hz-10 kHz range.

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“…Moreover, using DMSO as a solvent resulted in lower viscosity due to the solvent being less viscous and zein more freely dissolving than in GF. Ordinally, a good solvent for dissolving the substance could diminish the viscosity of the mixture because the domination of substance-solvent interaction is over substance-substance interaction [37][38][39][40]. The nature of dissolved zein-promoted formulations was more viscous from its large protein structure in the solution [18].…”

Section: Viscosity and Rheological Behaviormentioning

confidence: 99%

Levofloxacin HCl-Incorporated Zein-Based Solvent Removal Phase Inversion In Situ Forming Gel for Periodontitis Treatment

et al. 2023

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Zein is composed of nonpolar amino acids and is a water-insoluble protein used as the matrix-forming agent of localized in situ forming gel (ISG). Therefore, this study prepared solvent removal phase inversion zein-based ISG formulations to load levofloxacin HCl (Lv) for periodontitis treatment using dimethyl sulfoxide (DMSO) and glycerol formal (GF) as the solvents. Their physicochemical properties were determined, including viscosity, injectability, gel formation, and drug release. The topography of dried remnants after drug release was revealed using a scanning electron microscope and X-ray computed microtomography (μCT) to investigate their 3D structure and % porosity. The antimicrobial activities were tested against Staphylococcus aureus (ATCC 6538), Escherichia coli ATCC 8739, Candida albicans ATCC 10231, and Porphyromonas gingivalis ATCC 33277 with agar cup diffusion. Increasing zein concentration or using GF as the solvent notably enhanced the apparent viscosity and injection force of the zein ISG. However, its gel formation slowed due to the dense zein matrix barrier’s solvent exchange: the higher loaded zein or utilization of GF as an ISG solvent prolonged Lv release. The SEM and μCT images revealed the scaffold of dried ISG in that their % porosity corresponded with their phase transformation and drug release behavior. In addition, the sustainability of drug diffusion promoted a smaller antimicrobial inhibition clear zone. Drug release from all formulations was attained with minimum inhibitory concentrations against pathogen microbes and exhibited a controlled release over 7 days. Lv-loaded 20% zein ISG using GF as a solvent exhibited appropriate viscosity, Newtonian flow, acceptable gel formation and injectability, and prolonged Lv release over 7 days with efficient antimicrobial activities against various test microbes; thus, it is the potential ISG formulation for periodontitis treatment. Consequently, the Lv-loaded solvent removal zein-based ISGs proposed in this investigation offer promising potential as an efficacious drug delivery system for periodontitis treatment by local injection.

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Solvent effect on fluid characteristics of doxycycline hyclate-loaded bleached shellac in situ-forming gel and -microparticle formulations

Cited by 21 publications

References 29 publications

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Lime Peel Oil–Incorporated Rosin-Based Antimicrobial In Situ Forming Gel

Comparative Studies on the Electrical and Mechanical Behavior of Some Soldering and / or Impregnation Lacquers

Levofloxacin HCl-Incorporated Zein-Based Solvent Removal Phase Inversion In Situ Forming Gel for Periodontitis Treatment

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