Solvent Use in Various Industries

Wypych, George

doi:10.1016/b978-1-895198-65-2.50003-x

Cited by 3 publications

(2 citation statements)

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“…Figure 2 summarizes the main strategies used to improve the bioavailability of pharmaceutical compounds as well as the several strategies applied in the pharmaceutical arena, further highlighting the use of ILs as solvents, co-solvents, and hydrotropes in the field. In opposition to approaches where pure ILs are employed as solvents, applications inspired by co-solvency or hydrotropy phenomena resort to the preparation of a mixture, where ILs are added to a major solvent (typically water) [51,52]. Co-solvents are watersoluble compounds with the ability to overcome the limited solubility of hydrophobic solutes in an aqueous solution.…”

Section: Ils Used To Improve the Solubility (Bioavailability) Of Pharmaceuticalsmentioning

confidence: 99%

“…In opposition to approaches where pure ILs are employed as solvents, applications inspired by co-solvency or hydrotropy phenomena resort to the preparation of a mixture, where ILs are added to a major solvent (typically water) [ 51 , 52 ]. Co-solvents are water-soluble compounds with the ability to overcome the limited solubility of hydrophobic solutes in an aqueous solution.…”

Section: Ils Used To Improve the Solubility (Bioavailability) Of Pharmaceuticalsmentioning

confidence: 99%

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Advances Brought by Hydrophilic Ionic Liquids in Fields Involving Pharmaceuticals

et al. 2021

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The negligible volatility and high tunable nature of ionic liquids (ILs) have been the main drivers of their investigation in a wide diversity of fields, among which is their application in areas involving pharmaceuticals. Although most literature dealing with ILs is still majorly devoted to hydrophobic ILs, evidence on the potential of hydrophilic ILs have been increasingly provided in the past decade, viz., ILs with improved therapeutic efficiency and bioavailability, ILs with the ability to increase drugs' aqueous solubility, ILs with enhanced extraction performance for pharmaceuticals when employed in biphasic systems and other techniques, and ILs displaying low eco/cyto/toxicity and beneficial biological activities. Given their relevance, it is here overviewed the applications of hydrophilic ILs in fields involving pharmaceuticals, particularly focusing on achievements and advances witnessed during the last decade. The application of hydrophilic ILs within fields involving pharmaceuticals is here critically discussed according to four categories: (i) to improve pharmaceuticals solubility, envisioning improved bioavailability; (ii) as IL-based drug delivery systems; (iii) as pretreatment techniques to improve analytical methods performance dealing with pharmaceuticals, and (iv) in the recovery and purification of pharmaceuticals using IL-based systems. Key factors in the selection of appropriate ILs are identified. Insights and perspectives to bring renewed and effective solutions involving ILs able to compete with current commercial technologies are finally provided.

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Section: Ils Used To Improve the Solubility (Bioavailability) Of Pharmaceuticalsmentioning

confidence: 99%

Section: Ils Used To Improve the Solubility (Bioavailability) Of Pharmaceuticalsmentioning

confidence: 99%