The whole process of tobacco production is composed of many components, in which their operation and administration are currently independent. It is required to deploy smart manufacturing workflow for the whole production process, in order to realize centralized effective global scheduling. This requires an advanced administration control platform that has strong abilities of multisource data integration and automatic decision support. To bridge such research gap, this paper designs an optimal scheduling control system for smart manufacturing processes of tobacco industry. First of all, this work discusses major characteristics of future-generation production control patterns in intelligent tobacco factories (ITF). Then, a five-layer architecture for optimal scheduling control of ITF is proposed, which contains Internetof-Things layer, centralized control layer, model layer, platform layer and operation layer. In addition, a production scheduling optimization strategy is also developed for the proposed system to serve as the software algorithm that drives the running of whole smart manufacturing processes. Finally, this paper presents a comparative analysis of the proposed system's transformation in a cigarette factory. Naturally, the effectiveness of the proposed production optimization scheduling strategy is verified through simulation.