2021
DOI: 10.1101/2021.10.18.21265159
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Somatically mutated genes in fatty liver disease have minimal influence on germline risk

Abstract: BackgroundUnderstanding the genetics of liver disease has the potential to facilitate clinical risk stratification. We recently identified six genes and one lncRNA enriched for acquired somatic mutations in patients with NAFLD and alcohol-related liver disease. We hypothesised that germline variation in these genes would be associated with risk of liver disease development and contribute to prognostication.MethodsGenome-wide association study (GWAS) summary statistics were extracted from seven studies (>1.7… Show more

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