Somatostatin Receptor (SSTR) Expression and Proliferative Index (KI 67) in 100 Patients (PTS) with Gastroenteropancreatic Neuroendocrine Tumors (Gep-Nets). Clinical-Pathological Correlation

O’Connor, Juan Manuel; Belli, Susana; Pesce, Verónica; Bestani, Claudia; Méndez, Guillermo; Dominichini, E.; Cabanne, Ana; Lopez, Gabrielle; Marmissolle, F.; Roca, Elisa

doi:10.1016/s0923-7534(20)33717-0

Cited by 2 publications

(2 citation statements)

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“…Interestingly, the SSTR5 immunoreactivity was correlated with the presence of metastases and angioinvasion 74 . Other studies have previously demonstrated a positive correlation of SSTR2 and SSTR5 expression with a better prognosis and higher differentiation 75 - 80 .…”

Section: Somatostatin Receptors Mediate Anti-proliferative Signals Imentioning

confidence: 75%

PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms

Briest¹,

Grabowski²

2014

Theranostics

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Gastroenteropancreatic neuroendocrine neoplasms are heterogeneous in their clinical behavior and require therapies specially tailored according to staging, grading, origin and expression of peptide receptors. Despite extensive scientific efforts, the therapy options are still not satisfactory. The main reasons are due to the lack of a broad mechanistic knowledge, an insufficient classification of specific diagnostic sub-groups, and predictive markers. GEP-NEN tumors evade early diagnosis because of slow asymptomatic growth behavior and are frequently not detected until metastasized. How signaling networks contribute to tumor progression and how these networks interact remains unclear in large parts. In this review we summarize the knowledge on the growth factor responsive non-angiogenetic pathways in sporadic GEP-NENs, highlight promising mechanistic research approaches, and describe important therapy targets.

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Section: Somatostatin Receptors Mediate Anti-proliferative Signals Imentioning

confidence: 75%

PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms

Briest¹,

Grabowski²

2014

Theranostics

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“…En el Congreso de ASCO GI (EE.UU. ), 5 comentamos los hallazgos de la correlación clínico-patológica en cien pacientes atendidos por nuestro grupo y ratificamos las bases para la correcta tipificación de estos tumores, con el trabajo y el apoyo incondicional e iluminador de nuestros patólogos. Luego, participamos en la primera reunión del Consenso Latinoamericano, publicado en la revista Neuroendocrinology, journal oficial de ENET.…”

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Recomendaciones para el diagnóstico y el tratamiento de tumores neuroendocrinos de origen gastroenteropancreáticos

O’Connor

Roca²

2022

ACTA

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Somatostatin Receptor (SSTR) Expression and Proliferative Index (KI 67) in 100 Patients (PTS) with Gastroenteropancreatic Neuroendocrine Tumors (Gep-Nets). Clinical-Pathological Correlation

Cited by 2 publications

References 0 publications

PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms

PI3K-AKT-mTOR-Signaling and beyond: the Complex Network in Gastroenteropancreatic Neuroendocrine Neoplasms

Recomendaciones para el diagnóstico y el tratamiento de tumores neuroendocrinos de origen gastroenteropancreáticos

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