Somatotopic mapping of natural upper- and lower-extremity movements and speech production with high gamma electrocorticography

Ruescher, Johanna; Iljina, Olga; Altenmüller, Dirk‐Matthias; Aertsen, Ad; Schulze‐Bonhage, Andreas; Ball, Tonio

doi:10.1016/j.neuroimage.2013.04.102

Cited by 48 publications

(79 citation statements)

References 88 publications

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“…Recently a study including 3 native German speaking adults, compared changes in high-␥ spectral power related to retrospectively selected epochs of natural language with conventional ECS. On including both oral motor and speech sites as true positive, this study found a high specificity (96.7%) but very low sensitivity (18.9%) (Ruescher et al, 2013). The authors concluded that their procedure was not usable for clinical language mapping.…”

Section: Spontaneous Language Hgs and Task Based Ecs Mappingmentioning

confidence: 73%

“…During ECS, it is sometimes difficult to differentiate naming deficits as being due to cognitive (aphasia) versus motor (dysarthria) dysfunction, and the distinction is often based on neuroanatomy. Thus, taking both the conditions as true positive likely yields most ecologically valid comparison (Ruescher et al, 2013). These observations show that HGS mapping can be a useful screening method for pre-selection of electrodes to be tested for language by conventional ECS.…”

Section: Spontaneous Language Hgs and Task Based Ecs Mappingmentioning

confidence: 85%

“…More recently, high-␥ mapping of retrospectively identified non-experimental speech production was found to have 96.7% specificity, but only 18.9% sensitivity compared with either oral motor or language function detected by ECS in 3 adults. The authors concluded that their procedure was not usable for clinical language mapping (Ruescher et al, 2013). The present prospective study compares language mapping using high-␥ modulation associated with spontaneous interpersonal conversation with conventional ECS using visual naming tasks in patients with childhood-onset DRE.…”

Section: Introductionmentioning

confidence: 88%

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Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: Comparison with conventional electrical cortical stimulation

et al. 2015

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Section: Spontaneous Language Hgs and Task Based Ecs Mappingmentioning

confidence: 73%

Section: Spontaneous Language Hgs and Task Based Ecs Mappingmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 88%

See 1 more Smart Citation

Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: Comparison with conventional electrical cortical stimulation

et al. 2015

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“…[18][19][20][21] These studies have all assumed ESM as the gold standard for identifying eloquent cortex and predicting postresection deficits. The ideal gold standard for functional mapping is postoperative outcome following resection of a cortical site.…”

Section: Region Of Interest (Roi) Analysis For Each Patient We Per-mentioning

confidence: 99%

Spatial-temporal functional mapping of language at the bedside with electrocorticography

et al. 2016

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Objective: To investigate the feasibility and clinical utility of using passive electrocorticography (ECoG) for online spatial-temporal functional mapping (STFM) of language cortex in patients being monitored for epilepsy surgery.Methods: We developed and tested an online system that exploits ECoG's temporal resolution to display the evolution of statistically significant high gamma (70-110 Hz) responses across all recording sites activated by a discrete cognitive task. We illustrate how this spatial-temporal evolution can be used to study the function of individual recording sites engaged during different language tasks, and how this approach can be particularly useful for mapping eloquent cortex.Results: Using electrocortical stimulation mapping (ESM) as the clinical gold standard for localizing language cortex, the average sensitivity and specificity of online STFM across 7 patients were 69.9% and 83.5%, respectively. Moreover, relative to regions of interest where discrete cortical lesions have most reliably caused language impairments in the literature, the sensitivity of STFM was significantly greater than that of ESM, while its specificity was also greater than that of ESM, though not significantly so. Functional human brain mapping is commonly performed during or prior to invasive brain surgery for the treatment of drug-refractory epilepsy 1,2 and brain tumors. 3 The current gold standard, electrocortical stimulation mapping (ESM), is time-consuming 4,5 and often induces afterdischarges or seizures. 4,6,7 Additionally, it is difficult to rule out distant effects through diaschisis or action potentials evoked by stimulation.7-9 These limitations have long motivated the investigation of passive electrocorticographic (ECoG) recordings as a tool for rapidly and safely mapping cortical function prior to resective surgery. 10-12Here we introduce and test the feasibility and clinical utility of an online trial-based system for spatial-temporal functional mapping (STFM) of language cortex. High-gamma (HG, ; power changes have been demonstrated to be a robust and reliable index of task-related activation of cortical populations of neurons with high spatial and temporal specificity.13,14 The STFM system builds upon previous passive ECoG mapping software [15][16][17][18] by providing a trialbased framework for online display and statistical validation of HG dynamics.In 7 patients, estimates of the system's sensitivity and specificity for language mapping, relative to the benchmark of ESM, were the same or better than previous reports.18-21 Moreover, we found that relative to predefined language cortex boundaries, the sensitivity and specificity of *These authors contributed equally to this work.

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“…Although gamma activity has been proposed as the main frequency range allowing to reliably perform functional mapping of eloquent cortex [27], our study demonstrates that other frequency bands can also provide significant results and should be taken into consideration. Importantly, particular attention must be paid to a lower than gamma frequency ranges when motor function and motor imagery is concerned.…”

Section: Discussionmentioning

confidence: 79%

Characterization of cortical motor function and imagery-related cortical activity: Potential application for prehabilitation

Korostenskaja

Kapeller

Lee

et al. 2017

2017 IEEE International Conference on Systems, Man, and Cybernetics (SMC)

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Somatotopic mapping of natural upper- and lower-extremity movements and speech production with high gamma electrocorticography

Cited by 48 publications

References 88 publications

Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: Comparison with conventional electrical cortical stimulation

Electrocorticographic language mapping in children by high-gamma synchronization during spontaneous conversation: Comparison with conventional electrical cortical stimulation

Spatial-temporal functional mapping of language at the bedside with electrocorticography

Characterization of cortical motor function and imagery-related cortical activity: Potential application for prehabilitation

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