Somatotopic organization and columnar structure of vibrissae representation in the rat ventrobasal complex

Sugitani, Michio; Yano, J.; Sugai, Tokio; Ooyama, Hiroshi

doi:10.1007/bf00228125

Cited by 56 publications

(45 citation statements)

References 36 publications

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“…They were performed under different types and regimens of anesthesia, and among those that paid attention to receptive field size, three provided electrode tract reconstructions that registered the location of the recorded units (Rhoades et al, 1987;Ito, 1988;Sugitani et al, 1990). Two of these studies reported that VPM neurons with large receptive fields were more numerous dorsally, whereas cells with a single whisker receptive field were recorded deeper in vertical electrode penetrations through VPM (Ito, 1988;Sugitani et al, 1990).…”

Section: Discussionmentioning

confidence: 99%

A New Thalamic Pathway of Vibrissal Information Modulated by the Motor Cortex

Urbain¹,

Deschênes²

2007

J. Neurosci.

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Three ascending pathways of information processing have been identified so far in the vibrissal system of rodents. In the ventral posterior medial nucleus of the thalamus, two of these pathways convey information through the core and tail of barrel-associated structures, called barreloids. The other pathway transits through the posterior group nucleus. The present study provides anatomical and electrophysiological evidence for the existence of an additional pathway that passes through the head of the barreloids. This pathway arises from multiwhisker-responsive cells in the principal trigeminal nucleus and differs from the classic lemniscal pathway, in that constituent thalamic cells have multiwhisker receptive field and receive corticothalamic input from lamina 6 of the vibrissa motor cortex. It is suggested that this pathway might be involved in relaying signals encoding phase of whisker motion during free whisking.

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Section: Discussionmentioning

confidence: 99%

A New Thalamic Pathway of Vibrissal Information Modulated by the Motor Cortex

Urbain¹,

Deschênes²

2007

J. Neurosci.

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“…6, apical vs. basal). Recently, the present author (Ito, 1988) has reported that transient-and sustained-type neurones in the thalamic ventral posteromedial nucleus have a mean RF of 4-3 and 1-6 respectively in terms of the number of whiskers (see also Sugitani, Yano, Sugai & Ooyama, 1990;. The apparent discrepancy between the receptive field size and the dendritic field size can be explained by supposing that the multi-whisker transient-type thalamic neurones project to the multi-whisker transient-type pyramidal neurones in layer 5b.…”

Section: Tangential Sectionsmentioning

confidence: 92%

Simultaneous visualization of cortical barrels and horseradish peroxidase‐injected layer 5b vibrissa neurones in the rat.

Ito

1992

The Journal of Physiology

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SUMMARY1. Using diaminobenzidine (DAB) as a chromagen, horseradish peroxidaseinjected neurones and cytochrome oxidase-stained barrels were visualized simultaneously in the rat vibrissa cortex. Neurones were initially tested during extracellular recording for responses to whisker deflections. This was followed by intracellular injection of the soma with horseradish peroxidase (HRP) and histological processing to visualize the HRP-stained neurone in an incubation solution which contained, in addition to DAB, cytochrome C for cytochrome oxidase (CO) reaction of the barrels.2. Recording and intracellular staining were made in layer 5b under urethane anaesthesia. CO-stained barrels were observed in layer 4. Physiologically and morphologically characterized neurones were mostly large pyramidal neurones that responded to more than one whisker and displayed transient-type responses.3. In tangential sections, the apical dendrite of the HRP-filled neurone was followed from the soma level upward as it ascended through the barrelfield in layer 4. The cross-section of the apical dendrite was found in the periphery of the COstained barrel. Using the apical dendrite as a guide, the basal dendritic field of the layer 5b pyramidal neurone was aligned on the pattern of layer 4 barrels. The soma was seen to project basal dendrites in all directions, involving one or two neighbouring barrels/columns.4. In sixteen neurones examined in tangential sections, a complete spatial tuning map constructed by measuring sensitivity of the neurone to different whiskers could be compared to the basal dendritic field in relation to the pattern of overlying layer 4 barrels. The mean receptive field size in terms of the number of effective whiskers was 5 8 whereas the mean dendritic field size in terms of the number of barrels/columns involved was 2-2. In addition to the well-documented role of intracortical connectivity in elaboration of multi-whisker receptor fields in the cortical neurones, the role played by direct inputs from multi-whisker thalamic ventrobasal neurones was discussed.

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“…whisker receptive fields (Sugitani et al 1990), and thalamocortical cells that fire more robustly to adjacent whiskers also respond more robustly to the principal whisker (Bruno and Simons 2002). Similarly, the slowest conducting, longest latency, and weakest responding TCUs might be preferentially situated in the ventrolateral aspects of VPm where neurons may receive longer-latency inputs from the spinal trigeminal complex as well as from PrV (Pierret et al 2000).…”

Section: Bmentioning

confidence: 99%

Thalamocortical Conduction Times and Stimulus-Evoked Responses in the Rat Whisker-to-Barrel System

Simons

Carvell²,

Kyriazi³

et al. 2007

Journal of Neurophysiology

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Simons DJ, Carvell GE, Kyriazi HT, Bruno RM. Thalamocortical conduction times and stimulus-evoked responses in the rat whiskerto-barrel system. J Neurophysiol 98: 2842-2847, 2007. First published September 5, 2007 doi:10.1152/jn.00800.2007. Studies of the rodent whisker system indicate that somatosensory cortical circuitry operates at a millisecond timescale to transform sensory afferent signals from the thalamus. We measured axon conduction times and whisker-evoked responses of 48 thalamocortical (TC) neurons in the rat whisker-to-barrel pathway. Conduction times were derived from spike-triggered averages of local field potentials evoked in layer 4 cortical whisker-related barrels by the spontaneous firing of individual topographically aligned neurons in the ventral posterior medial thalamus. Conduction times varied fourfold, from 0.31 to 1.34 ms, and faster conducting TC neurons responded earlier and more robustly to controlled whisker deflections. Early arrival of highly responsive TC inputs, thought to contact inhibitory barrel neurons preferentially, could prime the cortical network, rendering it more selective for later-arriving signals.

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Somatotopic organization and columnar structure of vibrissae representation in the rat ventrobasal complex

Cited by 56 publications

References 36 publications

A New Thalamic Pathway of Vibrissal Information Modulated by the Motor Cortex

A New Thalamic Pathway of Vibrissal Information Modulated by the Motor Cortex

Simultaneous visualization of cortical barrels and horseradish peroxidase‐injected layer 5b vibrissa neurones in the rat.

Thalamocortical Conduction Times and Stimulus-Evoked Responses in the Rat Whisker-to-Barrel System

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