Some Abnormalities in the Nerve Supply of the Oral Mucosa

Marsland, E.A.; Fox, E. C.

doi:10.1177/003591575805101113

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…Nor is the distribution in the skin in good accordance with this theory. However, a comparison between hypersensitive and symptomless edentulous subjects revealed that in the hypersensitive subjects, many more intraepithelial fibers extended considerably further into the epithelium (Marsland and Fox, 1958).…”

Section: Nerve Fibers In the Lamina Epithelialis Mucosaementioning

confidence: 96%

Protein gene product 9.5-immunoreactive nerves and cells in human oral mucosa

et al. 1996

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Background Current conflicting information on the innervation of the human oral cavity indicates technical problems such as different detectability of the neural structures according to the various staining methods used and difficulties in reproducibility. The possibility of intraoral regional differences has not been properly considered. Methods Human biopsies of mucosa from different intraoral regions were prepared for immunohistochemistry using protein gene product 9.5 (PGP 9.5; a marker for neuronal structures). Results Nerves were found consistently in all the biopsies. The neural pattern showed clear regional differences. Intraepithelial nerve fibers were found in the gingiva, labia, palate, within certain fungiform papillae, and in some salivary excretory ducts. Organized nerve endings were found in varying frequencies in all but one (sublingual) region, appearing as lamellar (Meissner‐like), coiled or glomerular neural structures. Merkel cell‐neurite complexes were observed in the buccal, gingival, and palatal epithelia. Immunoreactive cells with many similarities to Merkel cells but without a neural connection were also encountered. Conclusions Conflicting results from earlier innervation studies of the oral cavity could be attributed to regional innervation differences. The distribution of the nerves also casts doubt on some of the present theories concerning the function(s) of intraoral nerves, such as the free nerve endings and the Merkel cell‐neurite complexes. © 1996 Wiley‐Liss, Inc.

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Section: Nerve Fibers In the Lamina Epithelialis Mucosaementioning

confidence: 96%

Protein gene product 9.5-immunoreactive nerves and cells in human oral mucosa

et al. 1996

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Nerve plexuses in the oral mucosa

Dixon

1963

Archives of Oral Biology

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Age changes in the two‐point discrimination threshold in human oral mucosa

Brill¹,

Tryde²,

Edwards

et al. 1974

J of Oral Rehabilitation

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Fifty young and fifty elderly subjects were tested by a two-point discrimination method applying an aesthesiometer to the mucous membr'ane of lips, cheeks and tongue. Two changes characteristic of ageing wer'e disclosed: (1) higher threshold values wer'e found in the older age group eoneomitant with (2) a gr'eater range of variation in these values. The importance of the perception of tactile stimuli from the structures tested is discussed in relation to adaptation to full dentures. It is suggested that signals arising from lips, cheeks and tongue assist the process of adaptation, whereas signals from the dentur'e foundation ean, on occasion, pr'event adaptation. IntroductionIt has been shown that three areas of facial skin innervated by the trigeminal nerve, when subjeeted to two-point discrimination tests exhibited a significant decrease in response in old people, compared to that in a group of young subjects (Brill et at., 1974). It was suggested that this decr'ease was due to the r'etrograde changes which occur thr'oughout the sensorium with ageing. Signs of involution in older subjeets have been found in receptors (Ronge, 1944), in intercalated nerve fibres (Cottrell, 1940), in spinal cell bodies (Gardner, 1940) and in the cerebr'al cor'tex (Brody, 1955). If the explanation offer'ed in r'elation to faeial skin is valid, at least in par't, then a similar decrease in sensibility should prevail when tactile stimuli ar'e applied to the oral mucosa. The pr'esent investigation was undertaken to test this hypothesis.A second objective was to discuss the assumption that perception of oral tactile stimuli has a bearing on the ability of patients to adapt to full dentur'es. The importance of this factor in relation to other's is still uncertain (Berr-y & Mahood, 1966).

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Some Abnormalities in the Nerve Supply of the Oral Mucosa

Cited by 6 publications

References 7 publications

Protein gene product 9.5-immunoreactive nerves and cells in human oral mucosa

Protein gene product 9.5-immunoreactive nerves and cells in human oral mucosa

Nerve plexuses in the oral mucosa

Age changes in the two‐point discrimination threshold in human oral mucosa

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