Some evidence for aldosterone action on 2,3-diphosphoglycerate level in human red cells

Böning, Dieter; Meier, Ulrich; Skipka, Werner; Külpmann, W. -R.; Meurer, K. A.

doi:10.1016/0026-0495(76)90154-2

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…Our observation of a relationship between 2,3-DPG and serum unconjugated oestriol may also be consistent with the finding that patients with placental insufficiency, who often show low levels of serum unconjugated oestriol, tend to have low levels of red cell 2,3-DPG [18]. From studies in vitro it has been shown that other steroid hormones may increase the level of red cell 2,3-DPG, such as hydrocortisone [7], aldosterone [8] and androgens [9]. The mechanism by which these steroids, as well as unconjugated oestriol, increase the concentration of red cell 2,3-DPG is not known.…”

Section: Discussionsupporting

confidence: 76%

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Correlation of serum unconjugated oestriol to red cell 2,3-diphosphoglycerate levels in diabetic pregnancy

Madsen

Ditzel

1983

Diabetologia

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Summary. In order to evaluate the possible underlying factors for the increase in red cell 2,3-diphosphoglycerate content observed in late diabetic pregnancy, its relationship with serum unconjugated oestriol, human placental lactogen, haemoglobin and hydrogen ion concentrations was investigated in 42 pregnant diabetic women. A significant correlation was found between red cell 2,3-diphosphoglycerate and serum unconjugated oestriol (r= 0.54, p < 0.001), whereas no correlation was present between 2,3-diphosphoglycerate and the following variables: arterial pH, haemoglobin concentration and human placental lactogen. The content of 2,3-diphosphoglycerate correlated significantly with haemoglobin-oxygen affinity expressed as Ps0 at pH 7.4 (r= 0.34, p < 0.05). The results of this study indicate that serum unconjugated oestriol may participate in the regulation of red cell 2,3-diphosphoglycerate content and thereby of the maternal blood oxygen release to the fetus.

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Section: Discussionsupporting

confidence: 76%

“…Steroid hormones, such as hydrocortisone, aldosterone and androgens may stimulate red cell 2,3-DPG synthesis [7][8][9]. We therefore decided to search for a correlation of red cell 2,3-DPG with serum unconjugated oestriol, and other blood variables in the late pregnancy of diabetic subjects.…”

mentioning

confidence: 99%

Correlation of serum unconjugated oestriol to red cell 2,3-diphosphoglycerate levels in diabetic pregnancy

Madsen

Ditzel

1983

Diabetologia

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“…The amount of 2,3-DPG synthesis depends on how much 1,3-DPG entered Rapoport-Luebering cycle and how much 2,3-DPG mutase reacts. The hormones known to increase the intraerythrocyte 2,3-DPG are thyroxine, 20 – 21) androgen, 22 – 24) aldosterone 25 – 26) and glucocorticoid. 27 – 29) Especially hydrocortisone and thyroxine are known to activate 2,3-DPG mutase and thus increase the conversion of 2,3-DPG from 1,3-DPG 20 , 29) …”

Section: Discussionmentioning

confidence: 99%

2, 3-Diphosphoglyceric Acid Changes in Uremia and During Hemodialysis

Kang

Park

1986

Korean J Intern Med

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The present study is an investigation of the mechanism of changes in erythrocyte 2,3-diphosphoglyceric acid (2,3-DPG) in patients with chronic renal failure during hemodialysis.The study was conducted on 7 Korean and 6 American patients on maintenance hemodialysis. The plasma pH of Korean patients was 7.31±0.02 before hemodialysis and 7.40±0.04 after hemodialysis (p<0.001). The pH of erythrocyte also increased from 7.13±0.02 to 7.20±0.03. The concentration of hemoglobin 2,3-DPG in Korean patients was 10.86±2.89 μmol/g before hemodialysis and 19.93±2.89 μmol/g after hemodialysis (p<0.001).Similar results were obtained in American patients. Hemoglobin 2,3-DPG was 12.54±2.53 and 18.76±6.73 μmol/g before and after dialysis respectively. Despite the presence of substantial anemia, hemoglobin 2,3-DPG prior to hemodialysis was significantly lower than the values obtained in the normal controls (17.45±4.3 μmol/g).The blood glucose increased from 93.3±8.5 mg/dl before dialysis to 117.1±6.1 mg/dl after hemodialysis in Korean patients but no significant change was detected in American patients. The increased blood glucose with hemodialysis observed in Korean patients was probably attributable to the lower baseline glucose concentration and the gain of glucose from dialysate, which had a glucose concentration of 186±34.1 mg/dl.The results suggest that the increase in 2,3-DPG with hemodialysis is probably caused by an increase of pH and an increased glucose utilization.

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“…II. 3D, 31 The implications of this hypothesis for phosphate replacement therapy in diabetic ketoacidosis are that erythrocytes may be able to respond to administered phosphate only after other metabolic functions are restored to norma!. Phosphate administration alone may therefore be insufficient to achieve the desired change in erythrocyte 2,3-DPG concentrations in disturbed metabolic states.…”

Section: Discussionmentioning

confidence: 99%

Insensitivity of Erythrocyte 2,3-Bisphosphoglycerate to Changes in Extracellular Phosphate Concentration in Vitro

1985

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SUMMARY.Erythrocytes maintained in vitro under controlled conditions at pH 7·40 were unable to respond to changes in extracellular phosphate concentrations with changes in intracellular 2,3-bisphosphoglycerate content over an 8 h incubation period. Increased extracellular phosphate concentrations did not retard the rate at which 2,3-bisphosphoglycerate concentrations fell when erythrocytes were incubated at pH 7·10. Elevated extracellular phosphate concentrations did not increase the rate of recovery of intracellular 2,3-bisphosphoglycerate concentrations when erythrocytes were returned to pH 7·40 having been incubated at pH 7·10. The rate at which 2,3-bisphosphoglycerate concentrations increased under these latter conditions was too slow to counterbalance any effect that adjustment of blood pH may have on the position of the haemoglobin-oxygen dissociation curve during treatment of diabetic ketoacidosis.

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Some evidence for aldosterone action on 2,3-diphosphoglycerate level in human red cells

Cited by 10 publications

References 13 publications

Correlation of serum unconjugated oestriol to red cell 2,3-diphosphoglycerate levels in diabetic pregnancy

Correlation of serum unconjugated oestriol to red cell 2,3-diphosphoglycerate levels in diabetic pregnancy

2, 3-Diphosphoglyceric Acid Changes in Uremia and During Hemodialysis

Insensitivity of Erythrocyte 2,3-Bisphosphoglycerate to Changes in Extracellular Phosphate Concentration in Vitro

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