Some features of hematological parameters and production of cytokines regulating inflammation in allergic rhinitis

Iraklionova, Natalia S.; Сергеевна, Ираклионова Наталья; Белан, Э. Б.; Борисовна, Белан Элеонора

doi:10.36691/rja1444

Cited by 2 publications

(1 citation statement)

References 9 publications

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“…Высокие значения сывороточного уровня МСР-1 у больных с активным воспалением в желудке подтверждают его функциональную активность как провоспалительного цитокина [5,7,22,23,24]. Serum IL-8 level in patients with chronic gastritis В настоящем исследовании во всех группах пациентов значения уровня МСР-1 в сыворотке крови находились в пределах референтных значений (рис.…”

Section: результатыunclassified

Features of the cytokine status in patients with HP-negative chronic gastritis

Iraklionova

Белан

Туркина

et al. 2022

jour

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Aim: to study the immunological characteristics of patients with H. pylori-unassociated chronic gastritis with its comorbidity with allergic rhinitis.Materials and methods. The study included patients aged 18 to 40 years: 47 healthy individuals (comparison group) and 140 people, of which 66 people had chronic gastritis, 43 people had seasonal allergic rhinitis in remission, 31 people had a combination of both. Conducted a clinical examination, determination of serum concentrations of IL-4, IL-5, IL-6, IL-8, IL-10, IL-18, MCP-1, total IgE, detection of IgG to the nuclear antigen of the Epstein-Barr virus.Results: During the study, we showed that H. pylori-non-associated chronic gastritis is characterized by a decrease in the level of monocyte-macrophage cytokines (IL-6 and IL-18, but not IL-8), but an increase in the production of Th2-dependent cytokines (IL-5 and IL-4), as well as total Ig E. In addition, H. pylori-non-associated chronic gastritis in patients without allergic rhinitis is associated with an increased frequency of detection of IgG to the nuclear antigen of the Epstein-Barr virus in blood serum (80.0% vs 48–55% of cases in other groups, p<0, 05).Conclusion. Thus, H. pylori-non-associated chronic gastritis is a multidisciplinary problem, which, from an immunopathogenetic point of view, is characterized by a Th2-phenotype of the immune response in such patients, including in the absence of allergic pathology, which determines the need for a wider involvement of data in the examination. patients of specialists of other proﬁles (allergists, infectious disease specialists, etc.).

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Section: результатыunclassified

Features of the cytokine status in patients with HP-negative chronic gastritis

Iraklionova

Белан

Туркина

et al. 2022

jour

Self Cite

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The Content of Cytokines Regulating Inflammation in Nasal Flushing in Chronic Rhinosinusitis in Elderly and Senile Persons

Tarasova,

Sokolova,

Belan

et al. 2024

Aspirantskiy Vestnik Povolzhiya

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ABSTRACT BACKGROUND. Chronic rhinosinusitis is a heterogeneous sinonasal inflammatory disease with constant symptoms and recurrent exacerbations, which affects about 10% of the world's population. Age-related changes in the nasal mucosa (involutive immunodeficiency, atrophic changes, etc.) can affect the course of the inflammatory process, which, in turn, should be borne in mind when planning therapeutic interventions. AIMS - to study the features of local production of IL-4, IL-6, IL-8, IL-10 in elderly and senile persons with chronic rhinosinusitis. MATERIALS AND METHODS. The study included patients aged 45 to 90 years with a confirmed diagnosis of "chronic rhinosinusitis" in the acute stage, who gave written informed consent to the study. The exclusion criteria were: age up to 45 years; allergic rhinitis; primary immunodeficiency; smoking; oncological disease of any organ system; chronic polypous rhinosinusitis; acute (exacerbation of chronic) diseases of other localization; vaccination; use of immunotropic drugs for 3 months before the start of the study. The scope of the laboratory examination included determination of the concentration of cytokines IL-4, IL-6, IL-8, IL-10 in nasal secretions by enzyme immunoassay. RESULTS. The analysis of the determined values showed that the maximum level of IL-4 was determined in younger persons with rhonic rhinosinusitis 45-59 years old compared with older persons. In our study, the maximum content of IL-6 occurred in a group of patients aged 75-90 years, while the cytokine level significantly exceeded IL-6 in a group of healthy age-related patients, which indicates a more pronounced inflammatory reaction in patients of the oldest group with chronic rhinosinusitis. Cytokine levels above 600 pg/ml were found mainly in patients with chronic rhinosinusitis. Patients of group 4 had high IL-10 values and their values went beyond the range of the comparison groups. CONCLUSION. The maximum level of macrophage-monocytic cytokines (IL-6 and IL-8) and anti-inflammatory IL-10 is determined in nasal flushing in patients with chronic rhinosinusitis aged 75-90 years, the highest detectable values of IL-4 are characteristic of patients aged 45-59 years.

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Some features of hematological parameters and production of cytokines regulating inflammation in allergic rhinitis

Cited by 2 publications

References 9 publications

Features of the cytokine status in patients with HP-negative chronic gastritis

Features of the cytokine status in patients with HP-negative chronic gastritis

The Content of Cytokines Regulating Inflammation in Nasal Flushing in Chronic Rhinosinusitis in Elderly and Senile Persons

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