Some organochlorine insecticide and polychlorinated biphenyl blood residues in infertile males in the general Israeli population of the middle 1980's

Pines, Anatol; Cucos, Similica; Ever-Hadani, P; Ron, M.

doi:10.1007/bf01055815

Cited by 27 publications

(18 citation statements)

References 27 publications

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“…No clear relationship between adverse general health effects and exposure to endocrine modulators has been established, although involvement of EDs in human pathology has been suggested in numerous studies (95)(96)(97)(98)(99)(100)(101)(102). The influence of chemical compounds on allergic immune responses remains also unclear.…”

Section: Resultsmentioning

confidence: 99%

Endocrine disrupters – potential modulators of the immune system and allergic response

Chałubiński¹,

Kowalski²

2006

Allergy

150

103

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Endocrine disrupters (EDs) are environmental pollutants of industrial or agricultural origin (e.g. herbicides, fungicides, insecticides, industrial chemicals) that may influence health of wildlife and human. Endocrine‐disrupting effect is obtained by mimicking the action of the steroid hormones and has been associated with several reproductive disorders as well as cancerogenesis both in animals and humans. EDs can also influence synthesis of cytokines, immunoglobulins, and cell mediators as well as immune cell activation and survival. Modulation by EDs of interleukin‐4 production, Th1/Th2 balance and IgE production suggest their potential effect on allergic immune responses. The aim of this review was to summarize data indicating a potential effect of EDs exposure on the immune system and allergic responses.

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Section: Resultsmentioning

confidence: 99%

Endocrine disrupters – potential modulators of the immune system and allergic response

Chałubiński¹,

Kowalski²

2006

Allergy

150

103

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“…The ratio of male to female births was reduced for offspring of men heavily exposed to dioxin in Seveso, Italy (54). In a study of 29 patients and 14 controls, significantly higher amounts of tetra-and pentachlorinated biphenyls, DDE, DDT, and lindane (γ-hexachlorocyclohexane) were present in male patients with infertility problems than in the controls (55). The levels of three PCB congeners (2,2´,4,4´,5,5´-hexachlorobiphenyl, 2,2´,3´,4,4´,5-hexachlorobiphenyl, and 2,3´,4,4´,5-pentachlorobiphenyl) were inversely correlated with sperm motility index in samples with a sperm count less than 20 million cells/mL (56).…”

Section: Sex Steroid Hormonal Disruptionmentioning

confidence: 99%

Understanding the human health effects of chemical mixtures.

Carpenter

Arcaro

Spink

2002

Environ Health Perspect

330

198

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Most research on the effects of chemicals on biologic systems is conducted on one chemical at a time. However, in the real world people are exposed to mixtures, not single chemicals. Although various substances may have totally independent actions, in many cases two substances may act at the same site in ways that can be either additive or nonadditive. Many even more complex interactions may occur if two chemicals act at different but related targets. In the extreme case there may be synergistic effects, in which case the effects of two substances together are greater than the sum of either effect alone. In reality, most persons are exposed to many chemicals, not just one or two, and therefore the effects of a chemical mixture are extremely complex and may differ for each mixture depending on the chemical composition. This complexity is a major reason why mixtures have not been well studied. In this review we attempt to illustrate some of the principles and approaches that can be used to study effects of mixtures. By the nature of the state of the science, this discussion is more a presentation of what we do not know than of what we do know about mixtures. We approach the study of mixtures at three levels, using specific examples. First, we discuss several human diseases in relation to a variety of environmental agents believed to influence the development and progression of the disease. We present results of selected cellular and animal studies in which simple mixtures have been investigated. Finally, we discuss some of the effects of mixtures at a molecular level.

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“…Analysis of semen for 74 PCB congeners showed that increasing concentrations of three congeners (PCBs 118, 137, and 153) were associated with decreasing sperm motility in men with oligozoospermia (Bush et al 1986). Another study found that blood concentrations of tetraCBs and penta-CBs, but not hexa-CBs and total PCBs, were significantly higher in infertile males than in normal subjects (Pines et al 1987). Some OCPs such as p.p'-DDE, have antiandrogenic activities and in utero or perinatal exposure to these compounds in laboratory animals may cause hypospadia, cryptorchidism, reduced sperm counts and testicular tumor in males (Skakkebaek et al 2001).…”

Section: Resultsmentioning

confidence: 96%

Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men

Çok

Durmaz

et al. 2009

Environ Monit Assess

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During the recent two decades, a remarkable drop in fertility rates has been noticed almost all over the world. A series of studies have showed that environmental factors had the primary role causing the observed adverse trends in the male reproductive health problems. Especially chlorinated hydrocarbons, for instance polychlorinated biphenyls (PCB) and pesticides, could mimic or antagonize the effects of steroid hormones, like estrogens and androgens and possibly interfering with male reproductive capacity. Organochlorine pesticides (OCPs) (i.e. p.p'-DDT, endosulfan...) and PCBs are widespread used chemicals in agriculture and industry for different purposes all over the world. Although direct evidence is lacking, theoretical considerations and epidemiological evidence implicate these compounds as potential hazards to human and wildlife reproductive health. For this purpose, in this study adipose tissue samples have provided from healthy males which were diagnosed as infertile men living in Ankara, Turkey at least for 5 years. Residual levels of OCPs (alpha-BHC, beta-BHC, gamma-BHC, HCB, Endosulfan I, II, p,p'-DDE, and p,p'-DDT) and seven major persistent PCB congeners (PCB 28, 52, 101, 118, 138, 153, and 180) were measured in 25 infertile men and 21 healthy men's adipose tissue samples by GC-ECD. Levels of OCPs and PCBs in adipose tissue of infertile men compared with those provided from controls. When the concentrations of each of the OCP were compared between the fertile and infertile groups, no statistical significance was obtained. Concentrations of each of the PCB congeners were compared between the fertile and infertile groups, no statistical significance was obtained (p > 0.05), except for 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) (p = 0.032) and 2,2',3,4,4',5,5'-heptachlorobiphenyl (PCB 180) (p = 0.017).

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Some organochlorine insecticide and polychlorinated biphenyl blood residues in infertile males in the general Israeli population of the middle 1980's

Cited by 27 publications

References 27 publications

Endocrine disrupters – potential modulators of the immune system and allergic response

Endocrine disrupters – potential modulators of the immune system and allergic response

Understanding the human health effects of chemical mixtures.

Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men

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