Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala

Twaij, Husni A.A.; Kéry, Ágnes; Al-Khazraji, Niran K.

doi:10.1016/0378-8741(83)90037-5

Cited by 72 publications

(43 citation statements)

References 6 publications

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“…The extract was administered by gavage at the doses of 1000, 2000, 4000, 8000, 10,000, 12,000 and 14,000 mg/ kg or by the intraperitoneal route at the doses of 100, 250, 500, 1000, 2000, 4000 and 8000 mg/kg. The general behavior of mice was observed continuously for 1 h after the treatment and then intermittently for 4 h, and thereafter over a period of 24 h (Twaij et al, 1983). The mice were further observed for up to 14 days following treatment for any signs of toxicity and death, and the latency of death.…”

Section: Acute Toxicity Studiesmentioning

confidence: 99%

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Taïwé¹,

Bum

Talla

et al. 2010

Pharmaceutical Biology

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Section: Acute Toxicity Studiesmentioning

confidence: 99%

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Taïwé¹,

Bum

Talla

et al. 2010

Pharmaceutical Biology

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“…Median lethal dose (LD 50 ) was evaluated by the Karber method. 17 The animals were executed after the examination was finished.…”

mentioning

confidence: 99%

Biocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo

Li¹,

Liu²,

Zhong³

et al. 2011

IJN

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Purpose: This research was conducted to assess the biocompatibility of the core-shell Fe 3 O 4 @ Au composite magnetic nanoparticles (MNPs), which have potential application in tumor hyperthermia. Methods: Fe 3 O 4 @Au composite MNPs with core-shell structure were synthesized by reduction of Au 3+ in the presence of Fe 3 O 4 -MNPs prepared by improved co-precipitation. Cytotoxicity assay, hemolysis test, micronucleus (MN) assay, and detection of acute toxicity in mice and beagle dogs were then carried out. Results:The result of cytotoxicity assay showed that the toxicity grade of this material on mouse fibroblast cell line (L-929) was classified as grade 1, which belongs to no cytotoxicity. Hemolysis rates showed 0.278%, 0.232%, and 0.197%, far less than 5%, after treatment with different concentrations of Fe 3 O 4 @Au composite MNPs. In the MN assay, there was no significant difference in MN formation rates between the experimental groups and negative control (P . 0.05), but there was a significant difference between the experimental groups and the positive control (P , 0.05). The median lethal dose of the Fe 3 O 4 @Au composite MNPs after intraperitoneal administration in mice was 8.39 g/kg, and the 95% confidence interval was 6.58-10.72 g/kg, suggesting that these nanoparticles have a wide safety margin. Acute toxicity testing in beagle dogs also showed no significant difference in body weight between the treatment groups at 1, 2, 3, and 4 weeks after liver injection and no behavioral changes. Furthermore, blood parameters, autopsy, and histopathological studies in the experimental group showed no significant difference compared with the control group. Conclusion:The results indicate that Fe 3 O 4 @Au composite MNPs appear to be highly biocompatible and safe nanoparticles that are suitable for further application in tumor hyperthermia.

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“…In contrast to the above mentioned positive effects, all the following plant extracts (Ditrichia graveolens, Alkanna strigosa, Sinapis arvensis, Centaurea iberica, Asphodelin lutea, Paronychia argentea, rosmarinus officinalis, Achillea santolina, Achillea micrantha, Allium sativum, Centaurea phyllacephala, Centaurea behen, Crataegus azarolus failed to produce a significant hypoglycemic or hyperglycemic effects. Some produced slight hyperglycemic effects or mild elevation in the plasma glucose levels (AI-Khazarji et al, 1993;Twaij et al, 1989;Al-Shamaony et al, 1994;Twaij et al, 1983;Twaij et al, 1987b;Twaij et al, 1988a & b), in comparison with effects obtained from the controls. On the other hand, Myrtus communis and Prosopis farcta produced a significant hyperglycemic activity at 90 min compared to zero time.…”

Section: Anti-diabetic and Hypoglycemic Studymentioning

confidence: 99%

Evaluation of the Anti-Diabetic and Anti-Ulcer Properties of Some Jordanian and Iraqi Medicinal Plants; a Screening Study

Twaij¹,

Al-Dujaili²

2014

JMED

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A large number of Jordanian and Iraqi medicinal plants have been used in traditional medicine for hypoglycemic and anti-ulcer activities. We have started a screening program to evaluate the activity of some of these plants and their extracts taking in consideration their use as an alternative therapy. Various parts of several plants were extracted and the hypoglycemic effects of the aqueous extracts have been examined in normal, glucose loaded and alloxan diabetic experimental animals. Teucrium polium aqueous extract was studied for its anti-ulcer activity of ulcers induced in rats by starvation and reserpine and/or stress. The aqueous extract of the aerial parts of Artemisia herba alba was administered orally to normoglycemic and alloxan diabetic rabbits and rats and found to produce a significant hypoglycemic activity (normoglycaemic: plasma glucose levels reduced from 116±4 to 90±3mg/dL after 90minutes, p<0.001; diabetic animals from 471±7 to 399±9mg/dL, p<0.001). The aerial aqueous extract of Phangnalon rupestre, Sinapis arvensis and Eryngium creticum also exhibited significant hypoglycemic effects in euglycaemic and glucose loaded rats. The other plants examined (Ditrichia graveolens, Alkanna strigosa, , Centaurea iberica, Asphodelin lutea, Paronychia argentea, rosmarinus officinalis, Achillea santolina, Achillea micrantha, Allium sativum, Centaurea phyllacephala, Centaurea behen, Crataegus azarolus, Prosopis farcta and Myrtus communis) failed to produce a significant change in the plasma glucose levels. One herb was comprehensively tested in detail for its anti-ulcer activity; Teucrium polium aqueous extract (intraperitoneally;150mg/kg) produced an average of 50% healing of ulcers where as the orally administered extract produced 85% healing activity of ulcers when compared with the controls.

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Some pharmacological, toxicological and phytochemical investigations on Centaurea phyllocephala

Cited by 72 publications

References 6 publications

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

Biocompatibility of Fe3O4@Au composite magnetic nanoparticles in vitro and in vivo

Evaluation of the Anti-Diabetic and Anti-Ulcer Properties of Some Jordanian and Iraqi Medicinal Plants; a Screening Study

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