Some Physiological Responses of Broad Breasted Bronze Poults to Chlorinated Naphthalene

Pudelkiewicz, W. J.; Boucher, R. V.; Callenbach, Ernest; Miller, R. C.

doi:10.3382/ps.0370185

Cited by 9 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pudelkiewicz et al (1958) observed that a mixture of pentaand hexa-chloronaphthalenes caused high mortality in poults but there was no accumulation of fluid in body cavities.…”

Section: Discussionmentioning

confidence: 96%

Hydropericardium and Ascites in Chicks Fed a Chlorinated Hydrocarbon

1962

View full text Add to dashboard Cite

“…Pudelkiewicz et al (1958) observed that a mixture of pentaand hexa-chloronaphthalenes caused high mortality in poults but there was no accumulation of fluid in body cavities.…”

Section: Discussionmentioning

confidence: 96%

Hydropericardium and Ascites in Chicks Fed a Chlorinated Hydrocarbon

1962

View full text Add to dashboard Cite

“…There was a striking resemblance of the edema disease symptoms to those recorded for the exudative diathesis syndrome of vitamin E deficiency in chicks, and it was thought that the outbreaks in poultry could be caused by induction of vitamin E deficiency by the use of poor quality fats (Friedman et al, 1959). Penta-and hexachloronaphthalenes caused high mortality in poults but there was no accumulation of fluids in body cavities (Pudelkiewicz et al, 1958). None of the above compounds can account for the suite of lesions characteristic of outbreaks of GLEMEDS in colonial fish-eating birds in the Great Lakes basin.…”

Section: Specificity In the Causes Of The Observed Effectsmentioning

confidence: 99%

Great lakes embryo mortality, edema, and deformities syndrome (GLEMEDS) in colonial fish‐eating birds: Similarity to chick‐edema disease

Gilbertson¹,

Kubiak

Ludwig³

et al. 1991

Journal of Toxicology and Environmental Health

342

150

View full text Add to dashboard Cite

Several species of colonial fish-eating birds nesting in the Great Lakes basin, including herring gulls, common terns and double-crested cormorants, have exhibited chronic impairment of reproduction. In addition to eggshell thinning caused by high levels of DDT and metabolites, the reproductive impairment is characterized by high embryonic and chick mortality, edema, growth retardation, and deformities, hence the name Great Lakes embryo mortality, edema, and deformities syndrome (GLEMEDS). The hypothesis has been advanced that GLEMEDS in colonial fish-eating birds resembles chick-edema disease of poultry and has been caused by exposure to chick-edema active compounds that have a common mode of action through the cytochrome P-448 system. Detailed evidence has been collected from the following three groups of studies on herring gulls in the lower Great Lakes during the early 1970s; Forster's terns in Green Bay, Wisconsin in 1983; and double-crested cormorants and Caspian terns in various locations in the upper Great Lakes from 1986 onwards. It has proved difficult to establish not only the onset of the disease in the various species at various locations but also the period in which chick-edema active compounds were released. Anecdotal evidence suggested that serious egg mortality in Lake Ontario herring gulls first occurred in 1966, through the signs of chick-edema disease were not looked for until 1974. Only indirect evidence is available on the date of the release of one of the presumed causal agents, 2,3,7,8-tetrachlorodibenzo-p-dioxin, but highest levels may have occurred in the early to mid 1960s. More reliable data show that the onset of the improvement of reproduction of Lake Ontario herring gulls coincided with the declines in organochlorine compounds and particularly 2,3,7,8-TCDD and PCB. Similarly, information on the onset of the disease and exposures in the Forster's tern and double-crested cormorants in Green Bay is uncertain but bird banders did not observe deformities until the 1970s, which corresponds with the onset of high levels of PCB. If the disappearance of the Caspian tern from Saginaw Bay in the mid 1960s corresponds with the onset of GLEMEDS at that location, then there is a close temporal relationship to the onset of high PCB levels. Chick-edema disease is difficult to diagnose because there is no specific lesion, but rather there is a suite of lesions.(ABSTRACT TRUNCATED AT 400 WORDS)

show abstract

“…Although no vitamin A analyses were carried out, the authors stated that there were no signs of vitamin A deficiency. Pudelkiewicz et al (1958) investigated effects of Halowax 1014 on Broad Breasted Bronze turkey poults. One-day-old turkey poults of both sexes were exposed for 40 days via the diet at doses of 0, 5, 10, 20, 50 and 100 mg/kg feed (N = 16, 8 of each sex).…”

Section: Studies In Rabbitsmentioning

confidence: 99%

“…Necroscopy revealed fluid accumulation in the body cavity and enlarged liver, which was darker in colour than normal. Pudelkiewicz et al (1958) also described an experiment with Broad Breasted Bronze turkey poults exposed to Halowax 1051. One-day-old poults were divided into two groups with 10 poults (5 of each sex).…”

Section: Studies In Rabbitsmentioning

confidence: 99%

Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food

Schrenk,

Bignami,

Bodin

et al. 2024

EFS2

View full text Add to dashboard Cite

EFSA was asked for a scientific opinion on the risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food. The assessment focused on hexaCNs due to very limited data on other PCN congeners. For hexaCNs in feed, 217 analytical results were used to estimate dietary exposures for food-producing and non-food-producing animals; however, a risk characterisation could not be performed because none of the toxicological studies allowed identification of reference points. The oral repeated dose toxicity studies performed in rats with a hexaCN mixture containing all 10 hexaCNs indicated that the critical target was the haematological system. A BMDL 20 of 0.05 mg/kg body weight (bw) per day was identified for a considerable decrease in the platelet count. For hexaCNs in food, 2317 analytical results were used to estimate dietary exposures across dietary surveys and age groups. The highest exposure ranged from 0.91 to 29.8 pg/kg bw per day in general population and from 220 to 559 pg/kg bw per day for breast-fed infants with the highest consumption of breast milk. Applying a margin of exposure (MOE) approach, the estimated MOEs for the high dietary exposures ranged from 1,700,000 to 55,000,000 for the general population and from 90,000 to 230,000 for breast-fed infants with the highest consumption of breast milk. These MOEs are far above the minimum MOE of 2000 that does not raise a health concern. Taking account of the uncertainties affecting the assessment, the Panel concluded with at least 99% certainty that dietary exposure to hexaCNs does not raise a health concern for any of the population groups considered. Due to major limitations in the available data, no assessment was possible for genotoxic effects or for health risks of PCNs other than hexaCNs.

show abstract

Some Physiological Responses of Broad Breasted Bronze Poults to Chlorinated Naphthalene

Cited by 9 publications

References 2 publications

Hydropericardium and Ascites in Chicks Fed a Chlorinated Hydrocarbon

Hydropericardium and Ascites in Chicks Fed a Chlorinated Hydrocarbon

Great lakes embryo mortality, edema, and deformities syndrome (GLEMEDS) in colonial fish‐eating birds: Similarity to chick‐edema disease

Risks for animal and human health related to the presence of polychlorinated naphthalenes (PCNs) in feed and food

Contact Info

Product

Resources

About