Some properties of bronopol, a new antimicrobial agent active against <i>Pseudomonas aeruginosa</i>

Croshaw, Betty; Groves, Michael J.; Lessel, B.

doi:10.1111/j.2042-7158.1964.tb07549.x

Cited by 42 publications

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“…In CF1652, the MIC values for the b-lactam antibiotics (Penicillin G to Cephalothin) which inhibit cell wall synthesis, were twofold less than those observed for the parent CF1648. A similar pattern of results were observed for trimethoprim, which blocks tetrahydrofolate synthesis, and is widely used against E. coli infections; polymyxin, which disrupts the structure and permeability of the plasma membrane; gentamicin which inhibits protein synthesis; 1,2-benzisothiazolin-3-one (BIT) and Bronopol which chemically react with -SH-containing protein/enzyme cellular components and are particularly active against actively metabolizing cells (Crowshaw, Groves and Lessel 1964;Stretton and Mason 1973).…”

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confidence: 62%

The intrinsic resistance of Escherichia coli to various antimicrobial agents requires ppGpp and sigmas

Greenway

England

1999

Lett Appl Microbiol

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GL A ND . 1999. We have examined the effect of a wide range of antimicrobial compounds (antibiotics and biocides) on the growth of various strains of Escherichia coli which vary in their ability to produce ppGpp and s s . We conclude that strains able to synthesize ppGpp, either in a RelA-or SpoT-dependent manner, possess a greater resistance to antimicrobial compounds compared with strains that cannot produce ppGpp. Investigation of an E. coli strain, unable to produce s s , and an isogenic parent strain, suggests that there is a requirement for this sigma factor in increased expression of intrinsic resistance. We propose that ppGpp is required to induce production of s s , which in turn directs gene expression of intrinsic resistance determinants.

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confidence: 62%

The intrinsic resistance of Escherichia coli to various antimicrobial agents requires ppGpp and sigmas

Greenway

England

1999

Lett Appl Microbiol

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“…'-9 In this instance the toxicities of meta-and para-substituted benzenes toward white mice are reported as best correlated by an interaction model l o g A x y = h x + by + eXeY (1) where ASY is the LD50 for a disubstituted benzene derivative relative to that of benzene, bx and b\ (or log A S H and log A H Y ) are the corresponding measures of toxicity for monosubstituted benzenes, and ex and el are parameters characterizing the effect on the LDJO due to substituent interaction in the disubstituted benzenes. An apparent exception to this generalization would seem to be found in the work of Botek, Kopeck9, and coworkers.…”

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Synthesis and antimicrobial activity of aliphatic nitro compounds

Clark¹,

Croshaw²,

Leggetter³

et al. 1974

J. Med. Chem.

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A series of simple aliphatic nitro compounds has been synthesized and tested for antimicrobial activity in vitro. Some of the compounds inhibit the growth of a broad range of fungi and bacteria including species of Pseudomonas. The most active compounds are alcohols containing the grouping -CBrN02-. Replacement of bromine by hydrogen, chlorine, or alkyl groups diminishes the activity. Structure-activity relationships are discussed.

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“…The bactericidal activity of bronopol (2-bromo-2-nitropropane-1,3-diol) against Pseudomonas aeruyinosa in particular, has been well documented (Crowshaw et al 1964;Stretton & Manson 1973;Bryce et al 1978) and it is currently very widely used as a preservative in medical and pharmaceutical products, cosmetics and shampoos (Bryce & Smart 1963;Anon. 1979).…”

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Pseudomonas tolaasii in mushroom (Agaricus bisporus) crops: activity of formulations of 2‐bromo‐2‐nitropropane‐1,3‐diol (bronopol) against the bacterium and the use of this compound to control blotch disease

Wong

Preece

1985

Journal of Applied Bacteriology

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The bactericidal activity of 2‐bromo‐2‐nitropropane‐1,3‐diol (bronopol) against Pseudomonas tolaasii, the causative organism of mushroom bacterial blotch, is enhanced by the addition of Tween 80, EDTA and phenylethanol. Results of tests with this pseudomonad confirm that bronopol is more active in alkaline solutions and enhancement of the bactericidal activity of this compound can be obtained by adding calcium carbonate, or mushroom casing (limestone and peat). Quantitative observations show that sterility can be achieved with bronopol at 100 µg/ml in 24 h following artificial inoculation of casing with Ps. tolaasii in glass flasks. On miniature mushroom beds in controlled environments a single application of bronopol, in tap water during routine watering, controls bacterial blotch disease. Bronopol is a slow‐acting bactericide, destroying Ps. tolaasii in mushroom casing and effecting control of bacterial blotch disease.

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Some properties of bronopol, a new antimicrobial agent active against Pseudomonas aeruginosa

Cited by 42 publications

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The intrinsic resistance of Escherichia coli to various antimicrobial agents requires ppGpp and sigmas

The intrinsic resistance of Escherichia coli to various antimicrobial agents requires ppGpp and sigmas

Synthesis and antimicrobial activity of aliphatic nitro compounds

Pseudomonas tolaasii in mushroom (Agaricus bisporus) crops: activity of formulations of 2‐bromo‐2‐nitropropane‐1,3‐diol (bronopol) against the bacterium and the use of this compound to control blotch disease

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