Some tenets pertaining to electrospray ionization mass spectrometry

Cole, Richard B.

doi:10.1002/1096-9888(200007)35:7<763::aid-jms16>3.0.co;2-#

Cited by 332 publications

(142 citation statements)

References 76 publications

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…(Figure 7). In the previous paper, 3ϩ metal ions in solution gave mainly M(NO 3 ) 4 Ϫ ions. Those elements with a stable 2ϩ oxidation state in solution were also seen as M(NO 3 ) 3 Ϫ ions [19].…”

Section: Ms and Cid Of Nitrate Complexes Of Group 1 And 2 Metalsmentioning

confidence: 86%

“…With the present system, more in-source fragmentation is observed, as shown in the spectrum for Fe 3ϩ in Figure 8. While Fe(NO 3 ) 4 Ϫ is the most abundant ion from the Fe 3ϩ sample , there is a substantial amount of the oxo product FeO(NO 3 ) 3 Ϫ and also Fe(NO 3 ) 3 Ϫ . A small amount of the cluster Fe 2 O(NO 3 ) 5 Ϫ is observed.…”

Section: Ms and Cid Of Nitrate Complexes Of Group 1 And 2 Metalsmentioning

confidence: 99%

“…A fter the pioneering studies of Yamashita and Fenn [1], ESI-MS has revolutionized the analysis of biological molecules [2][3][4][5]. This method also provides valuable information about inorganic and organometallic compounds [6 -8] and the interactions and binding of metal ions to biological molecules [9 -11].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Tandem mass spectrometry of metal nitrate negative ions produced by electrospray ionization

Byers

Houk

2003

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

M(NO 3 ) xϪ ions are generated by electrospray ionization (ESI) of metal solutions in nitric acid in negative ion mode. Collision-induced reactions of these ions are monitored in a tandem mass spectrometer (MS) of quadrupole-octopole-quadrupole (QoQ) geometry. For Group 1and 2 elements, the M(NO 3 ) x Ϫ ions dissociate into NO 3 Ϫ and neutral metal nitrate molecules. These elements also form some M x (NO 3 ) xϩ1 Ϫ clusters, especially Li ϩ . Metal nitrate ions from transition elements and Group 13 elements fragment into oxo products and also undergo internal electron transfer to leave the M atom in a lower oxidation state. To calibrate the collision energy, the dissociation energy of O-NO 2 Ϫ is found to be 5.55 eV, about 0.76 eV lower than a value derived from thermochemistry. Most studies of small inorganic ions have been done in positive ion mode [14 -18]. Many metal-solvent clusters, e.g., M xϩ (H 2 O) n , n ϭ 1 to 6, are typically formed under "soft" ion extraction conditions [7,17,18]. Highly charged metal ions tend to react with solvent molecules to yield hydroxy or methoxy ions when energetic collision conditions are used to remove solvent during ion extraction. Preserving the original form of the metal ion in positive mode generally requires element-specific optimization of ion extraction conditions and leads to a variety of ion-solvent clusters.Previous work from our group [19] showed that an excess of nitric acid can be used to produce M(NO 3 ) x Ϫ ions in negative ion mode. A single set of ion extraction conditions yields these ions for many elements. This early work was done with only one stage of MS. The present work reports collision-induced dissociation (CID) reactions of these M(NO 3 ) x Ϫ ions in a triple "quadrupole" MS, actually a QoQ instrument. Experimental Samples and Sample PreparationConcentrated nitric acid was purchased from J. T. Baker (Phillipsburg, NJ) and used without further purification. Aliquots of the concentrated acid were mixed with HPLC grade methanol and deionized water (18 M⍀, Barnstead Nanopure, Newton, MA) to form a solvent of 0.05% nitric acid in 25% water:75% methanol. Aliquots of aqueous, acidic metal stock solutions (1000 ppm, Spex Certiprep, Metuchen, NJ ) were diluted with solvent to the desired concentrations.

show abstract

Section: Ms and Cid Of Nitrate Complexes Of Group 1 And 2 Metalsmentioning

confidence: 86%

Section: Ms and Cid Of Nitrate Complexes Of Group 1 And 2 Metalsmentioning

confidence: 99%

See 1 more Smart Citation

Tandem mass spectrometry of metal nitrate negative ions produced by electrospray ionization

Byers

Houk

2003

J. Am. Soc. Mass Spectrom.

View full text Add to dashboard Cite

show abstract

“…Nevertheless, we can expect that other electrospray particle generators should similarly produce particles that are enhanced in the relative amount of surface active species. 65 The effective SDS coverage for Θ SDS e 1.0 ML can be calculated from the assumed values of ε NaCl (either from the solution composition or from the ZSR fits). 5 This analysis reveals for the 5.0 wt/wt % SDS/NaCl nanoparticles Θ SDS ) 0.4 ML assuming the composition is that of the electrosprayed solution.…”

Section: Discussionmentioning

confidence: 99%

Hygroscopic Growth and Deliquescence of NaCl Nanoparticles Mixed with Surfactant SDS

et al. 2010

View full text Add to dashboard Cite

Several complementary experimental and theoretical methodologies were used to explore water uptake on sodium chloride (NaCl) particles containing varying amounts of sodium dodecyl sulfate (SDS) to elucidate the interaction of water with well-defined, environmentally relevant surfaces. Experiments probed the hygroscopic growth of mixed SDS/NaCl nanoparticles that were generated by electrospraying aqueous 2 g/L solutions containing SDS and NaCl with relative NaCl/SDS weight fractions of 0, 5, 11, 23, or 50 wt/wt %. Particles with mobility-equivalent diameters of 14.0(±0.2) nm were size selected and their hygroscopic growth was monitored by a tandem nano-differential mobility analyzer as a function of relative humidity (RH). Nanoparticles generated from 0 and 5 wt/wt % solutions deliquesced abruptly at 79.1(±1.0)% RH. Both of these nanoparticle compositions had 3.1(±0.5) monolayers of adsorbed surface water prior to deliquescing and showed good agreement with the Brunauer−Emmett−Teller and the Frenkel−Halsey−Hill isotherms. Above the deliquescence point, the growth curves could be qualitatively described by Köhler theory after appropriately accounting for the effect of the particle shape on mobility. The SDS/NaCl nanoparticles with larger SDS fractions displayed gradual deliquescence at a RH that was significantly lower than 79.1%. All compositions of SDS/NaCl nanoparticles had monotonically suppressed mobility growth factors (GFm) with increasing fractions of SDS in the electrosprayed solutions. The Zdanovskii−Stokes−Robinson model was used to estimate the actual fractions of SDS and NaCl in the nanoparticles; it suggested the nanoparticles were enhanced in SDS relative to their electrospray solution concentrations. X-ray photoelectron spectroscopy (XPS), FTIR, and AFM were consistent with SDS forming first a monolayer and then a crystalline phase around the NaCl core. Molecular dynamics simulations of water vapor interacting with SDS/NaCl slabs showed that SDS kinetically hinders the initial water uptake. Large binding energies of sodium methyl sulfate (SMS)−(NaCl)4, H2O−(NaCl)4, and SMS−H2O−(NaCl)4 calculated at the MP2/cc-pVDZ level suggested that placing H2O in between NaCl and surfactant headgroup is energetically favorable. These results provide a comprehensive description of SDS/NaCl nanoparticles and their properties. Disciplines Chemistry CommentsReprinted (adapted) ReceiVed: October 8, 2009; ReVised Manuscript ReceiVed: January 5, 2010 Several complementary experimental and theoretical methodologies were used to explore water uptake on sodium chloride (NaCl) particles containing varying amounts of sodium dodecyl sulfate (SDS) to elucidate the interaction of water with well-defined, environmentally relevant surfaces. Experiments probed the hygroscopic growth of mixed SDS/NaCl nanoparticles that were generated by electrospraying aqueous 2 g/L solutions containing SDS and NaCl with relative NaCl/SDS weight fractions of 0, 5, 11, 23, or 50 wt/wt %. Particles with mobility-equivalent diameters of ...

show abstract

“…Electrospray ionisation, a technique most commonly used in mass spectrometry [14,15] to create gas phase ions of large molecules such as polymers and proteins, involves passing a solution of the molecule of interest through an emitter (often a metal capillary with OD < 1 mm) held at a high voltage (typically a few kilovolts). At the emitter tip, the large electric field causes polarisation of the solvent and the formation of a Taylor cone.…”

Section: Introductionmentioning

confidence: 99%

Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates

Fornari

Roberts

Temperton

et al. 2015

Journal of Colloid and Interface Science

View full text Add to dashboard Cite

We demonstrate in this work the deposition of a large biological molecule (fibronectin) on polymeric substrates in a high vacuum environment using an electrospray deposition system. Fibronectin was deposited and its distribution and structure investigated and retention of function (ability to promote cell adhesion) on return to liquid environment is shown. AFM was used to monitor changes in the morphology of the surface before and after fibronectin deposition, whilst the biological activity of the deposited protein is assessed through a quantitative analysis of the biomolecular adhesion and migration of fibroblast cells to the modified surfaces. For the first time we have demonstrated that using high vacuum electrospray deposition it is possible to deposit large protein molecules on polymeric surfaces whilst maintaining the protein activity. The deposition of biological molecules such as proteins with the retention of their activity onto clean well-controlled surfaces under vacuum condition, offers the possibility for future studies utilizing high resolution vacuum based techniques at the atomic and molecular scale providing a greater understanding of protein-surface interface behaviour of relevance to a wide range of applications such as in sensors, diagnostics and tissue engineering.

show abstract

Some tenets pertaining to electrospray ionization mass spectrometry

Cited by 332 publications

References 76 publications

Tandem mass spectrometry of metal nitrate negative ions produced by electrospray ionization

Tandem mass spectrometry of metal nitrate negative ions produced by electrospray ionization

Hygroscopic Growth and Deliquescence of NaCl Nanoparticles Mixed with Surfactant SDS

Electrospray deposition in vacuum as method to create functionally active protein immobilization on polymeric substrates

Contact Info

Product

Resources

About