Sonochemical Synthesis, Characterization and Molecular Docking of Thiazole and Triazole Tethered Tetra-Substituted Imidazoles.

Abstract

Sonochemical synthesis of tetra-substituted imidazole derivatives tethered with thiazole and triazole moieties carried out by condensation reaction, involving aldehyde, benzil, ammonium acetate and selected amino azole moiety with brick clay as catalyst. The synthesized tetra-substituted imidazole derivatives were characterized using FT-IR, NMR spectroscopy. Molecular docking studies of the synthesized tetra-substituted imidazole derivatives for their antimicrobial potency were also performed. These derivatives scored satisfactorily and can be the possible lead for the future drug candidate against microbial pathogens