Sonochemistry as a General Procedure for the Synthesis of Coumarins­, Including Multigram Synthesis

Pinto, Ligia S. da Silveira; Souza, Marcus V. N. de

doi:10.1055/s-0036-1590201

Cited by 37 publications

(10 citation statements)

References 24 publications

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“…Substituted coumarins were prepared via sonochemistry using active methylene compounds and 2-hydroxybenzaldehydes (Knoevenagel reaction) or resorcinol (Pechmann reaction). Good yields, short reaction times and easy adaptability to bulk production are sure advantages of this procedure [ 79 ].…”

Section: Synthetic Strategies For the Preparation Of Coumarinsmentioning

confidence: 99%

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

et al. 2018

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Many naturally occurring substances, traditionally used in popular medicines around the world, contain the coumarin moiety. Coumarin represents a privileged scaffold for medicinal chemists, because of its peculiar physicochemical features, and the versatile and easy synthetic transformation into a large variety of functionalized coumarins. As a consequence, a huge number of coumarin derivatives have been designed, synthesized, and tested to address many pharmacological targets in a selective way, e.g., selective enzyme inhibitors, and more recently, a number of selected targets (multitarget ligands) involved in multifactorial diseases, such as Alzheimer’s and Parkinson’s diseases. In this review an overview of the most recent synthetic pathways leading to mono- and polyfunctionalized coumarins will be presented, along with the main biological pathways of their biosynthesis and metabolic transformations. The many existing and recent reviews in the field prompted us to make some drastic selections, and therefore, the review is focused on monoamine oxidase, cholinesterase, and aromatase inhibitors, and on multitarget coumarins acting on selected targets of neurodegenerative diseases.

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Section: Synthetic Strategies For the Preparation Of Coumarinsmentioning

confidence: 99%

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

et al. 2018

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“…Under ultrasonic irradiation, several chemical processes have been performed in high yield with reduced reaction durations [ 67 ]. The interaction of Zn(OAc) 2 and H 2 BDC in DMF during ultrasonic irradiation for 10 min yielded nanostructures with a breadth of 150–300 nm and a height of 2–5 µm.…”

Section: Synthesis Of Zn-based Mofsmentioning

confidence: 99%

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Ali

Meng

2021

Molecules

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The design and structural frameworks for targeted drug delivery of medicinal compounds and improved cell imaging have been developed with several advantages. However, metal-organic frameworks (MOFs) are supplemented tremendously for medical uses with efficient efficacy. These MOFs are considered as an absolutely new class of porous materials, extensively used in drug delivery systems, cell imaging, and detecting the analytes, especially for cancer biomarkers, due to their excellent biocompatibility, easy functionalization, high storage capacity, and excellent biodegradability. While Zn-metal centers in MOFs have been found by enhanced efficient detection and improved drug delivery, these Zn-based MOFs have appeared to be safe as elucidated by different cytotoxicity assays for targeted drug delivery. On the other hand, the MOF-based heterogeneous catalyst is durable and can regenerate multiple times without losing activity. Therefore, as functional carriers for drug delivery, cell imaging, and chemosensory, MOFs’ chemical composition and flexible porous structure allowed engineering to improve their medical formulation and functionality. This review summarizes the methodology for fabricating ultrasensitive and selective Zn-MOF-based sensors, as well as their application in early cancer diagnosis and therapy. This review also offers a systematic approach to understanding the development of MOFs as efficient drug carriers and provides new insights on their applications and limitations in utility with possible solutions.

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“…From the first described synthesis of the coumarin nucleus in 1868 through the Perkin reaction, synthetical coumarins can be obtained by different methods including the aforementioned Perkin reaction, the Pechman reaction, Reformatsky reaction, Claisen reaction, Witting reaction, the Ringclosing methathesis reaction, Knovenegal reaction, and some other variations incorporating microwave assistance or applying sonochemistry, among others [8][9][10][11][12][13][14][15].…”

Section: One Possible Classification Between Different Proposed Subclmentioning

confidence: 99%

Coumarins into Polyurethanes for Smart and Functional Materials

et al. 2020

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Polyurethanes are of undoubted interest for the scientific community and the industry. Their outstanding versatility from tailor-made structures turns them into major polymers for use in a wide range of different applications. As with other polymers, new, emerging molecules and monomers with specific attributes can provide new functions and capabilities to polyurethanes. Natural and synthetic coumarin and its derivatives are characterised by interesting biological, photophysical and photochemical properties. Then, the polyurethanes can exploit those features of many coumarins which are present in their composition to achieve new functions and performances. This article reviews the developments in the proper use of the special properties of coumarins in polyurethanes to produce functional and smart materials that can be suitable for new specific applications.

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Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis

Cited by 37 publications

References 24 publications

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Coumarins into Polyurethanes for Smart and Functional Materials

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Sonochemistry as a General Procedure for the Synthesis of Coumarins­, Including Multigram Synthesis

Cited by 37 publications

References 24 publications

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

Coumarin: A Natural, Privileged and Versatile Scaffold for Bioactive Compounds

Zinc-Based Metal-Organic Frameworks in Drug Delivery, Cell Imaging, and Sensing

Coumarins into Polyurethanes for Smart and Functional Materials

Contact Info

Product

Resources

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Sonochemistry as a General Procedure for the Synthesis of Coumarins, Including Multigram Synthesis