Sonographic umbilical vessel morphometry and perinatal outcome of fetuses with a lean umbilical cord

Ghezzi, Fabio; Raio, Luigi; Duwe, D. Günter; Cromi, Antonella; Karousou, Evgenia; Dürig, P.

doi:10.1002/jcu.20076

Cited by 39 publications

(31 citation statements)

References 17 publications

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“…[4] In a study on fetuses with sonographically measured low umbilical cord cross-sectional area, Ghezzi et al , found a significant relationship between umbilical vein cross-sectional area below the 10 th percentile and adverse neonatal outcome. [5]…”

Section: Introductionmentioning

confidence: 99%

Evaluation of umbilical cord thickness, cross-sectional area, and coiling index as predictors of pregnancy outcome

Tahmasebi

Alighanbari

2011

Indian Journal of Radiology and Imaging

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Aims:This study was designed to evaluate the relationship of sonographic measurements of umbilical cord thickness, cross-sectional area, and coiling index with pregnancy outcome (low birth weight, 5-min Apgar score, and meconium staining).Materials and Methods:From January 2010 to January 2011, among 255 singleton pregnant women who were referred for routine pregnancy USG after 20 weeks of gestation, 223 fulfilled the study criteria. In these patients, the diameter, cross-sectional area, and coiling index were measured in a free loop of umbilical cord. The pregnancies were followed till delivery, when birth weight, presence of meconium staining, and 5-min Apgar score were recorded. The sonographic measurements and clinical findings were analyzed to determine any correlation.Results:A statistically significant correlation was observed between small umbilical cord thickness and cross-sectional area and low birth weight (LBW), with sensitivity of 52.9% and 57.9%, specificity of 95.0% and 94.4%, positive predictive value of 52.6% and 52.0%, and negative predictive value of 95.0% and 95.0%, respectively. Also noted was significant correlation between small umbilical cord thickness and cross-sectional area with meconium staining (P<0.001). No significant correlation was seen between umbilical cord thickness and cross-sectional area with low 5-min Apgar score. There was no statistically significant correlation between umbilical cord coiling index and LBW, 5-min Apgar score, and meconium staining.Conclusion:Umbilical cord diameter and cross-sectional area measured after 20 weeks of gestation are useful for predicting LBW and meconium staining and have the potential to serve as markers for adverse pregnancy outcome.

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Section: Introductionmentioning

confidence: 99%

Evaluation of umbilical cord thickness, cross-sectional area, and coiling index as predictors of pregnancy outcome

Tahmasebi

Alighanbari

2011

Indian Journal of Radiology and Imaging

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“…Umbilical cord is part of fetal metabolism and it has been suggested that thickness of umbilical cord may be related to mechanism of fetal nutrition [19]. Both thick and thin umbilical cords might be dependent on quantity of Warton’s jelly and/or changing size of umbilical cord vessels in cross-sectional area [20]. Further larger studies are needed to explain probable relationship between umbilical cord, morphology of Warton’s jelly, and fetal outcome in early pregnancy.…”

Section: Discussionmentioning

confidence: 99%

Is there any relationship between low PAPP-A levels and measures of umbilical vein and placental thickness during first trimester of pregnancy?

Uysal

Tutuş

Çağlı

et al. 2017

North Clin Istanbul

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OBJECTIVE:Low pregnancy-associated plasma protein A (PAPP-A) level is associated with adverse perinatal outcomes. The purpose of this study was to evaluate relationship between umbilical cord diameter (UCD), umbilical vein and artery diameters (UVD, UAD), placental thickness, and PAPP-A level at gestational age of between 11 and 14 weeks.METHODS:UCD, UVD, UAD, and placental thickness of 246 women were assessed during ultrasound examination at between 11 and 14 weeks of gestation, as well as measurement of nuchal translucency (NT) and crown-rump length (CRL). Patients were divided into 2 groups according to PAPP-A percentile. Group 1 comprised 23 patients who had low PAPP-A (<0.44 multiple of medians [MoM], <10th percentile) and Group 2 was made up of 223 patients with PAPP-A of >0.44 MoM, >10th percentile. Calipers used for measurement were placed inner edge to inner edge of echogenic boundaries of the vessel. Largest sections of all vessels (UV and both arteries) were evaluated. Thickest part of the placenta was used for placental thickness measurement.RESULTS:Narrow UCD (<4.5±0.6 mm) was associated with low PAPP-A level (p=0.02). There was no significant difference in UVD, UAD, or placental thickness between groups. There was no significant difference in gestational age, CRL, or NT between groups. Fetal birth weight was significantly lower in Group 1 (p=0.03).CONCLUSION:Closer attention to women with low-risk, healthy pregnancies and low PAPP-A level in first trimester screening results is recommended. They should be routinely screened for background medical risk factors and umbilical cord morphology in first trimester scan.

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“…A lean or hypo-coiled umbilical cord has been described as a factor contributing to IUGR and perinatal complications 8 . Studies have been published on the relation between umbilical cord thickness 9 even from the first trimester and perinatal outcome, 10 and prenatal indices for coiling and umbilical cord diameter have been published 11 and related to fetal outcome, but no simple and reliable methods has been developed to evaluate umbilical cord length sonographically, only sophisticated experimental models not yet applicable in clinical medicine have been developed 12 …”

Section: Discussionmentioning

confidence: 99%

Intrauterine Growth Restriction Associated with Excessively Long Umbilical Cord

Schmid

Jacquemyn

Loor

2013

Clinics and Practice

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We present a 37-week female baby, known with intrauterine growth restriction since 25 weeks of pregnancy, born with a placenta with an excessive long umbilical cord (ELUC), without any other abnormalities. ELUC is mostly an incidental finding after delivery, but represents a potentially detectable intrauterine cause of growth restriction. A system that allows ultrasound measurement of the length of the umbilical cord could highly increase antenatal diagnosis of ELUC.

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Sonographic umbilical vessel morphometry and perinatal outcome of fetuses with a lean umbilical cord

Abstract: Among fetuses with a sonographically lean umbilical cord, a significant relationship exists between an umbilical vein area below or equal to the 10th percentile and an adverse neonatal outcome.

Cited by 39 publications

References 17 publications

Evaluation of umbilical cord thickness, cross-sectional area, and coiling index as predictors of pregnancy outcome

Evaluation of umbilical cord thickness, cross-sectional area, and coiling index as predictors of pregnancy outcome

Is there any relationship between low PAPP-A levels and measures of umbilical vein and placental thickness during first trimester of pregnancy?

Intrauterine Growth Restriction Associated with Excessively Long Umbilical Cord

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