Sorbitan sesquioleate; a rare cause of contact allergy in consecutively patch tested dermatitis patients

Bennike, Niels H.; Johansen, Jeanne Duus

doi:10.1111/cod.12536

Cited by 21 publications

(41 citation statements)

References 18 publications

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“…In the Danish study, three of the six patients with concomitant positive reactions to SSO and FM I had no positive reactions to any of the eight single constituents of FM I, containing 1% SSO. The remaining three patients had three or more positive reactions to the single constituents of the mix . The eight SSO‐positive patients with either concomitant positive or doubtful reactions to FM I were further evaluated.…”

Section: Results Of Fm I Breakdown Testing In Patients With and Withomentioning

confidence: 89%

“…Six (75%) of eight patients did not react to a perfume mix 6% pet. (containing no SSO and the same ingredients as FM I, except for amyl cinnamal and Evernia prunastri extract), and two patients with ++ reactions to FM I had doubtful reactions to the perfume mix not containing SSO …”

Section: Results Of Fm I Breakdown Testing In Patients With and Withomentioning

confidence: 99%

“…In the Danish study mentioned above, sensitization to SSO was identified in nine (0.2%) patients; the proportion of FM I‐positive patients with concomitant positive reactions to SSO was 1.4% . Eight of the nine SSO‐positive individuals were also tested with FM I; six (75%) had positive reactions (+/++) to FM I, and the other two (25%) had doubtful reactions (?+) to FM I.…”

Section: Relationship Between Contact Allergy To Sso and Contact Allementioning

confidence: 96%

“…There are few recent data on routine testing with SSO in European countries. In Denmark, in the period 2010 to 2014, 4637 patients were tested at one centre with SSO 20% pet., and there were nine (0.2%) positive reactions . The German Contact Dermatitis Research Group (DKG) included SSO 20% pet.…”

Section: Frequency Of Contact Allergy To Sso In Routine Testingmentioning

confidence: 99%

“…Otherwise, a positive reaction to fragrance mix cannot adequately be interpreted.” In 2001, Orton and Shaw recommended “that all patients tested with the fragrance mix should have concomitant testing with SSO”, because “it is clear that patients may be falsely attributed as having an allergic reaction to fragrance mix.” In 2015, the Information Network of Departments of Dermatology (IVDK) concluded: “Our results indicate that reactivity to SSO markedly affects the outcome of patch testing with FM I and its single constituents. SSO must be an obligatory part of the full FM I breakdown test, and should ideally be included in the baseline series.” Finally, in 2016, Bennike and Johansen in Denmark, despite finding a low prevalence of 0.2% positive reactions to SSO in a 5‐year period, commented that “in order to correctly diagnose the individual patient, concomitant patch testing with FM I and SSO should be performed, and baseline testing with SSO will remain part of the standard procedure at our department.”…”

Section: Introductionmentioning

confidence: 99%

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Adding sorbitan sesquioleate to the European baseline series: Necessary, reasonable, or unavoidable?

Groot¹,

Gilissen

Geier

et al. 2019

Contact Dermatitis

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Positive reactions to fragrance mix I (FM I) are frequent in consecutively patch tested patients suspected of having allergic contact dermatitis. However, the FM I test preparations contain 5% of the emulsifier sorbitan sesquioleate (SSO), and it is well known that SSO can cause contact allergic reactions in its own right. Indeed, the available data show that some patients with contact allergy to SSO react to FM I but are not allergic to fragrances. When SSO is not tested, this situation may go unnoticed, a wrong diagnosis of fragrance allergy may be given to the patient, and unjustified advice to avoid fragrances and fragranced products will be given in such cases. To avoid such suboptimal patient care, we postulate that testing with SSO in all patch tested individuals is mandatory. As it is well known that only a minority of FM I-reactive patients will undergo a breakdown test with the ingredients and SSO, testing with SSO in all patients can only be achieved by adding it to the European baseline series. Not testing with SSO may also result in misinterpretation of patch test reactions to Myroxylon pereirae resin and 2-hydroxyethyl methacrylate in the baseline series, as both (may) contain SSO, and, for the same reason, of reactions to several other hapten test materials. K E Y W O R D Scontact allergy, European baseline series, fragrance mix, Myroxylon pereirae resin, patch test interpretation, perfume allergy, sorbitan sesquioleate

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Section: Results Of Fm I Breakdown Testing In Patients With and Withomentioning

confidence: 89%

Section: Results Of Fm I Breakdown Testing In Patients With and Withomentioning

confidence: 99%

Section: Relationship Between Contact Allergy To Sso and Contact Allementioning

confidence: 96%

Section: Frequency Of Contact Allergy To Sso In Routine Testingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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