In the present study, the influence of Hall and ion-slip current on steady magnetohydrodynamics mixed convective, Ohmic heating, and viscous dissipative Casson fluid flow over an infinite vertical porous plate in the presence of Soret effect and chemical reaction are investigated. The modeling equations are transformed into dimensionless equations and then solved analytically through the multiple regular perturbation law. Computations are performed graphically to analyze the behavior of fluid velocity, temperature, concentration, skin friction, Nusselt number, and Sherwood number on the vertical plate with the difference of emerging physical parameters. This study reflects that the incremental values of Casson fluid parameter and Schmidt number lead to reduction in velocity. However, fluid velocity rises due to enhancement of ion-slip parameter but an opposite effect is observed in case of Hall parameter. In addition, the Sherwood number declines with enhancing dissimilar estimators of the chemical reaction, Schmidt number, as well as Soret number. K E Y W O R D S Casson fluid, Hall and ion-slip current, MHD, multiple regular perturbation law, Ohmic heating