Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis

Yu, Wenjing; Hu, Yuehuai; Liu, Zhiping; Guo, Kaiteng; Ma, Dinghu; Peng, Mingxia; Wang, Yuemei; Zhang, Jing; Zhang, Xiaolei; Wang, Panxia; Zhang, Jiguo; Liu, Peiqing; Lu, Jing

doi:10.1016/j.apsb.2023.08.016

Cited by 10 publications

(1 citation statement)

References 52 publications

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“…Iron overload may also be a secondary effect initiated with the onset of ferroptosis. In doxorubicin (DOX)‐induced cardiac injury, deposition of DOX–Fe 2+ complex in mitochondria leads to mitochondria‐dependent ferroptosis, 20 DOX also induced high expression of TFRC 21,22 . In addition, TFRC was reported to induce macrophage activation and infiltration through STAT3‐Ccl2 signaling pathway, promoting the development of heart failure 23 .…”

Section: Discussionmentioning

confidence: 99%

A novel circPIK3C2A/miR‐31‐5p/TFRC axis drives ferroptosis and accelerates myocardial injury

Miao,

Yang,

et al. 2024

MedComm

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Iron overload is common in cardiovascular disease, it is also the factor that drives ferroptosis. Noncoding RNAs play an important role in heart disease; however, their regulatory role in iron overload‐mediated ferroptosis remains much unknown. In our study, the iron overload model in mice was constructed through a high‐iron diet, and ammonium iron citrate treatment was used to mimic iron overload in vitro. We found iron overload induced ferroptosis in cardiomyocytes, which was dependent on the high expression of transferrin receptor (TFRC). MiR‐31‐5p was downregulated during iron overload; it inhibited cardiomyocyte ferroptosis by targeting TFRC. CircPIK3C2A, a highly expressed circRNA in the heart, was upregulated when iron was overloaded. CircPIK3C2A enhanced the expression of TFRC by sponging miR‐31‐5p and promoted ferroptosis during iron overload. Our results reveal a novel mechanistic insight into noncoding RNA‐based ferroptosis and identify the circPIK3C2A/miR‐31‐5p/TFRC axis as a promising therapeutic target for myocardial damage.

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Section: Discussionmentioning

confidence: 99%