Soy protein compared with whey protein ameliorates insulin resistance by regulating lipid metabolism, AMPK/mTOR pathway and gut microbiota in high-fat diet-fed mice

Ji, Andong; Chen, Wei; Liu, Chang; Zhang, Tianyu; Shi, Runjia; Wang, Xinqi; Xu, Hongjian; Li, Duo

doi:10.1039/d3fo01093g

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…6). MTH is a gene closely related to longevity, and down‐regulation of MTH could reduce the production of free radicals and effectively enhance the antioxidant capacity of fruit flies 59 …”

Section: Discussionmentioning

confidence: 99%

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Yang,

Cao,

Zhang

et al. 2024

J Sci Food Agric

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BACKGROUNDChinese mugwort (Artemisia argyi) possesses extensive pharmacological activities associated with anti‐tumour, antioxidative and anti‐inflammatory effects. The present study aimed to investigate the antioxidant and anti‐ageing effects of A. argyi extract (AAE) on the fruit fly (Drosophila melanogaster) ageing model by detecting antioxidant enzyme activities and the mRNA level of antioxidant genes.RESULTSAAE could significantly lengthen the mean lifespan, 50% survival days, and maximum lifespan of D. melanogaster, especially when the amount of AAE added reached 6.68 mg mL−1, the mean lifespan of both female and male flies increased by 23.74% and 22.30%, respectively, indicating the effective life extension effect of AAE. At the same time, AAE could improve the climbing ability and tolerance to hydrogen peroxide in D. melanogaster. In addition, the addition of AAE effectively increased the activities of copper‐zinc‐containing superoxide dismutase, manganese‐containing superoxide dismutase and catalase in D. melanogaster and reduced the contents of malondialdehyde. Moreover, when reared with diets containing AAE, the expression of antioxidant‐related genes SOD1, SOD2 and CAT was up‐regulated in D. melanogaster and down‐regulated for MTH genes.CONCLUSIONThe study indicates that AAE effectively enhances the antioxidant capacity of D. melanogaster and has potential applications as an antioxidant and anti‐ageing agent in the nutraceutical industry. © 2024 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 99%

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Yang,

Cao,

Zhang

et al. 2024

J Sci Food Agric

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“…Du et al [33] reported that daily FBT administration (400 mg/kg) inhibited the hepatic steatosis and adipocyte size increment associated with HFD [23], which aligns with the findings of our current investigation. The levels of hepatic lipid metabolismrelated genes were measured (Figure 3), as the liver is a vital organ involved in lipid homeostasis [35]. In the current study, FLT and FBT administration (400, 800 mg/kg BW) improved lipid metabolism in HFD-induced obese mice by downregulating the levels of fatty acid synthesis-related genes (SREBP-1c, ACC, and FAS) and upregulating the levels of fatty acid oxidation-related genes (PPARα and AMPK).…”

Section: Flt and Fbt Alleviated Lipid Homeostasis And Oxidative Stressmentioning

confidence: 99%

Fu Loose Tea Administration Ameliorates Obesity in High-Fat Diet-Fed C57BL/6J Mice: A Comparison with Fu Brick Tea and Orlistat

Liang,

Wu,

et al. 2024

Foods

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Fu tea is receiving increasing attention for its specific aroma, flavor, and dramatic functional benefits. Herein, we explored the effects and underlying mechanisms of Fu loose tea (FLT), Fu brick tea (FBT), and diet pills (orlistat) on a high-fat diet (HFD)-induced obesity. The results indicated that FLT and FBT administration effectively inhibited weight gain, glucose metabolic dysregulation, fat accumulation in organs, hepatic and kidney injury, and oxidative stress induced by HFD. Additionally, FLT and FBT treatments improved the lipid profiles and reduced the production of proinflammatory cytokines by regulating the expression levels of lipid metabolism- and inflammation-related genes. Furthermore, FLT and FBT ameliorated the gut microbiota dysbiosis in HFD-mice in a dose-dependent relationship by increasing the abundance of family Verrucomicrobiaceae and genus Akkermansia and Turicibacter and simultaneously reducing the abundance of family Erysipelotrichaceae and genus Bifidobacterium; in contrast, orlistat did not exert a regulatory effect on gut microbiota similar to FLT and FBT to improve HFD-induced obesity. KEGG analysis of gut microbiota annotation revealed that “metabolism” was the most enriched category. This study further provides a theoretical basis for FLT and FBT to be potential supplements to alleviate diet-induced obesity.

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Lotus seed protein ameliorates hepatic lipid metabolic disorders in high-fat diet-fed mice via activating the PPARα signaling pathway

Chen,

Lu,

Lang

et al. 2024

Food Bioscience

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Soy protein compared with whey protein ameliorates insulin resistance by regulating lipid metabolism, AMPK/mTOR pathway and gut microbiota in high-fat diet-fed mice

Abstract: The findings of soy protein versus whey protein supplementation on glycemic regulation are inconsistent. The aim of the present study was to investigate the preventive effect of soy protein isolate...

Cited by 5 publications

References 57 publications

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Artemisia argyi extract exerts antioxidant properties and extends the lifespan of Drosophila melanogaster

Fu Loose Tea Administration Ameliorates Obesity in High-Fat Diet-Fed C57BL/6J Mice: A Comparison with Fu Brick Tea and Orlistat

Lotus seed protein ameliorates hepatic lipid metabolic disorders in high-fat diet-fed mice via activating the PPARα signaling pathway

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