Soybean seed isoflavones respond differentially to phosphorus applications in low and high phosphorus soils

Wang, Xiaohui; Liu, Shuangli; Yin, Xinhua; Bellaloui, Nacer; McClure, Michael A.; Mengistu, Alemu

doi:10.1007/s10705-019-09982-3

Cited by 5 publications

(4 citation statements)

References 47 publications

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“…[35] reported that the total isoflavones ranged from 745 to 5253.98 μg/g, with highest mean of 2689.27 μg/g observed in some regions and up to 2518.91 and 1942.78 μg/g in others due to climatic conditions. Similar results have been reported by other studies [25][26][27][36][37][38]. Our results showed over 1000 μg/g and in some cases over 1100 μg/g.…”

Section: Isoflavone Contents Frequency Distribution Heritability and Correlationsupporting

confidence: 93%

The Soybean High Density ‘Forrest’ by ‘Williams 82’ SNP-Based Genetic Linkage Map Identifies QTL and Candidate Genes for Seed Isoflavone Content

Knizia

Yuan

Bellaloui

et al. 2021

Plants

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Isoflavones are secondary metabolites that are abundant in soybean and other legume seeds providing health and nutrition benefits for both humans and animals. The objectives of this study were to construct a single nucleotide polymorphism (SNP)-based genetic linkage map using the ‘Forrest’ by ‘Williams 82’ (F×W82) recombinant inbred line (RIL) population (n = 306); map quantitative trait loci (QTL) for seed daidzein, genistein, glycitein, and total isoflavone contents in two environments over two years (NC-2018 and IL-2020); identify candidate genes for seed isoflavone. The FXW82 SNP-based map was composed of 2075 SNPs and covered 4029.9 cM. A total of 27 QTL that control various seed isoflavone traits have been identified and mapped on chromosomes (Chrs.) 2, 4, 5, 6, 10, 12, 15, 19, and 20 in both NC-2018 (13 QTL) and IL-2020 (14 QTL). The six QTL regions on Chrs. 2, 4, 5, 12, 15, and 19 are novel regions while the other 21 QTL have been identified by other studies using different biparental mapping populations or genome-wide association studies (GWAS). A total of 130 candidate genes involved in isoflavone biosynthetic pathways have been identified on all 20 Chrs. and among them 16 have been identified and located within or close to the QTL identified in this study. Moreover, transcripts from four genes (Glyma.10G058200, Glyma.06G143000, Glyma.06G137100, and Glyma.06G137300) were highly abundant in Forrest and Williams 82 seeds. The identified QTL and four candidate genes will be useful in breeding programs to develop soybean cultivars with high beneficial isoflavone contents.

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Section: Isoflavone Contents Frequency Distribution Heritability and Correlationsupporting

confidence: 93%

The Soybean High Density ‘Forrest’ by ‘Williams 82’ SNP-Based Genetic Linkage Map Identifies QTL and Candidate Genes for Seed Isoflavone Content

Knizia

Yuan

Bellaloui

et al. 2021

Plants

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“…Kandungan isoflavon pada kedelai terutama isoflavone aglikon genistein merupakan senyawa yang memiliki efek kuat dalam penurunan kolesterol pada darah. 4 FDA (Food and Drug Administration) telah mengakui bahwa makanan yang mengandung protein kedelai merupakan salah satu pelindung manusia dari penyakit jantung koroner. Asupan 25 g protein kedelai per hari diakui akan mengurangi kolesterol (3,77%), LDL-kolesterol (5,25%), triasilgliserol (7,27%) dan peningkatan serum secara signifikan HDL-kolesterol (3,03%).…”

Section: Pendahuluanunclassified

“…Diantara berbagai jenis turunan senyawa isoflavon, aktivitas antioksidan tertinggi dimiliki oleh isoflavon aglikon, lebih tepatnya adalah senyawa isoflavone aglikon genistein. 4 Patogenesis penyakit jantung koroner dapat dilihat pada gambar 1.…”

Section: Ekstrak Isoflavon Pada Biji Kedelai (Glycine Soja)unclassified

“…23 Diantara berbagai jenis turunan senyawa isoflavon, aktivitas antioksidan tertinggi dimiliki oleh isoflavon aglikon, lebih tepatnya adalah senyawa isoflavone aglikon genistein. 4 Genistein berperan dalam cell repairing, metabolisme lemak dan glukosa serta melindungi sel β-pankreas sehingga dapat mencegah diabetes mellitus, apoptosis sel berlebihan seerta penyakit jantung seperti penyakit jantung koroner. 24 Kemungkinan jalur molekuler yang memodulasi isoflavon kedelai dalam adiposity dapat dilihat pada gambar 2.…”

Section: Mekanisme Administrasi Dan Distribusi Ekstrak Biji Kedelai (Glycine Soja) Terenkapsulasi Smeddsunclassified

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Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner

Swastika

Ristiani

Gorintha

et al. 2021

Comm. Health. Epid. J

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Background: Coronary heart diseases (CHD) is a disorder that caused by blockage of coronary arteries due to the process of atherosclerosis which disrupts the blood supply to the heart muscle. According to Sample Registration System (SRS) Indonesia in 2014, CHD is a second highest cause of death after stroke that is 12,9% of all cause of death in Indonesia. Therefore, this study aims to examining the effect of soybean extract encapsulated with Self Microemulsifying Drug Delivery System (SMEDDS) on LDL levels in coronary heart model rats. Based on various study, isoflavone aglycone genistein is the main flavonoid in soybean seed that has potential as an antioxidant. To increase bioavailability of aglycone isoflavones, a SMEDDS is needed. In this regard, the purpose of this reseach is to examine the potential of soybean seed (Glycine soja) extract to reduced cholesterol in CHD.Methods: The method used is a literature review with literature sources in the form of relevant articles from the search engines, namely Google Scholar, Pubmed, ScienceDirect, and Research Gate. Inclusion criteria included journals containing the keywords “soybean (Glycine soja)”, “Coronary Heart Disease”, “SMEDDS”, and “genistein isoflavone aglycone”.Result: Isoflavone aglycone as an potential antioxidant that is able to bind free radicals and and also lowering LDL, Triglycerides, and glucose levels in hyperglycemic states and increasing HDL.Conclusion : Soybean seed extract with SMEDDS encapsulation have a potential to decrease LDL level in coronary heart disease.

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An insight into in vitro strategies for bioproduction of isoflavones

Vidya

Saravanan

Halka

et al. 2021

Plant Biotechnol Rep

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Soybean seed isoflavones respond differentially to phosphorus applications in low and high phosphorus soils

Cited by 5 publications

References 47 publications

The Soybean High Density ‘Forrest’ by ‘Williams 82’ SNP-Based Genetic Linkage Map Identifies QTL and Candidate Genes for Seed Isoflavone Content

The Soybean High Density ‘Forrest’ by ‘Williams 82’ SNP-Based Genetic Linkage Map Identifies QTL and Candidate Genes for Seed Isoflavone Content

Potensi Formulasi Self Microemulsifying Drug Delivery System (SMEDDS) Ekstrak Biji Kedelai (Glycine soja) Terhadap Penurunan Kolesterol pada Penyakit Jantung Koroner

An insight into in vitro strategies for bioproduction of isoflavones

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