SP-A and TLR4 localization in lung tissue of SM-exposed patients

Ghaffarpour, Sara; Foroutan, Abbas; Askari, Nayere; Abbas, Fatemeh Mashhadi; Salehi, Elham; Nikoonejad, Maryam; Naghizadeh, Mohammad Mehdi; Eskandarian, Maryam; Moghadam, Keivan Gohari; Akbari, Hassan; Yarmohammadi, Mohammad Ebrahim; Ghazanfari, Tooba

doi:10.1016/j.intimp.2019.105936

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…( Beharka et al., 2002 ). The study also found that the CRD domains of SP-A bind to the soluble extracellular domains of TLR2, TLR4 and MD-2 receptors via a Ca 2+ -dependent pathway ( Awasthi et al., 2019 ; Ghaffarpour et al., 2020 ), and SP-A can regulate the expression of TLR2 and TLR4 in macrophages after transcription ( Que and Shen, 2016 ). However, although SP-A can up-regulate the expression of TLR2 in macrophages, it also inhibits the TLR2-mediated NF-κB signaling pathway.…”

Section: Sp-a-linked Communications Between Ams and Aecs During Mp In...mentioning

confidence: 92%

Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection

Xue

Wang

Han

2023

Front. Cell. Infect. Microbiol.

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Mycoplasma pneumoniae, as one of the most common pathogens, usually causes upper respiratory tract infections and pneumonia in humans and animals. It accounts for 10% to 40% of community-acquired pneumonia in children. The alveolar epithelial cells (AECs) are the first barrier against pathogen infections, triggering innate immune responses by recruiting and activating immune cells when pathogens invade into the lung. Alveolar macrophages (AMs) are the most plentiful innate immune cells in the lung, and are the first to initiate immune responses with pathogens invasion. The cross-talk between the alveolar epithelium and macrophages is necessary to maintain physiological homeostasis and to eradicate invaded pathogen by regulating immune responses during Mycoplasma pneumoniae infections. This review summarizes the communications between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infections, including cytokines-medicated communications, signal transduction by extracellular vesicles, surfactant associated proteins-medicated signal transmission and establishment of intercellular gap junction channels.

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Section: Sp-a-linked Communications Between Ams and Aecs During Mp In...mentioning

confidence: 92%

Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection

Xue

Wang

Han

2023

Front. Cell. Infect. Microbiol.

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Krebs von den Lungen-6 and surfactant protein-A in interstitial pneumonia with autoimmune features

et al. 2021

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Interstitial pneumonia with autoimmune features (IPAF) is a special subtype of interstitial lung disease that has received worldwide attention. Krebs von den Lungen-6 (KL-6) and surfactant protein-A (SP-A) can be used as an important biomarker of interstitial lung disease, but its exact relationship with IPAF is poorly understood. A total of 65 IPAF patients were included in the study and were followed up for 52 weeks. The KL-6 and SP-A were evaluated by chemiluminescence enzyme immunoassay. The above indicators were tested at 2 time points, baseline (the first admission of patients) and 52 weeks. We also collected the indicators of antinuclear antibodies and rheumatoid factor. Based on high-resolution computed tomography evaluations, patients were divided into: aggravation, stable, and improvement group. At same time, 30 age-matched normal people as normal control were recruited, the same information was collected. Correlations among the groups were compared and analyzed. The KL-6 and SP-A level in IPAF patients were significantly higher than normal controls (fold increase = 11.35 and 1.39, both P < .001) and differed significantly at baseline and 52 weeks in IPAF (difference ratio = 37.7% and 21.3%, P < .05, both). There were significant differences at baseline and 52 weeks ( r values of aggravation, improvement, and stable groups for KL-6 were 0.705, 0.770, and 0.344, P = .001, .001, and .163, and for SP-A the r value were 0.672, 0.375, and 0.316, P = .001, .126, and .152). In aggravation group, KL-6 and SP-A were correlated with CT scores (both P < .05). Diffusing capacity of the lung for carbon monoxide (DLCO) and forced vital capacity (FVC), % predicted showed a progressive downward trend, with a significant difference at baseline and 52 weeks in IPAF patients (difference ratio = 23.8% and 20.6%, both P < .05). There was a significant correlation between KL-6 and FVC % predicted and DLCO (both P < .05), SP-A showed negatively correlated with DLCO, but not significantly correlated with FVC % predicted ( P < .05 and .47). This study demonstrated that KL-6 and SP-A can reflect disease progression, and both 2 play a key role at reflection of lung epithelial cell injury and fibrosis degree in IPAF.

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SP-A and TLR4 localization in lung tissue of SM-exposed patients

Cited by 2 publications

References 29 publications

Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection

Interaction between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infection

Krebs von den Lungen-6 and surfactant protein-A in interstitial pneumonia with autoimmune features

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