Sp166a Retrospective Study on Clinical and Histological Pattern of Presentation in Lupus Nephritis Patients - A Single Centre Experience in Sri Lanka

Basnayake, Duminda; Wazil, Abdul; Nanayakkara, Nishantha; Mahanama, Buddhisha; Ratnatunga, Neelakanthi; Dissanayake, Kushangi; Priyadarshana, P.

doi:10.1093/ndt/gfz103.sp166

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“…The epidemiology of primary and secondary glomerular diseases may differ within the nation due to different socio-economic and ethnic backgrounds in different parts of the country. Similar to our findings, single center studies conducted in Sri Lanka showed nephrotic range proteinuria as the most common indication for renal biopsy [27,28]. Comparably studies done in other parts of the world including Bangladesh [29], Africa [30], India [15], Poland [31], China [32] and Romania [33,34] showed nephrotic range proteinuria as the most prevalent indication for renal biopsy.…”

Section: Discussionsupporting

confidence: 90%

“…Among secondary GN, lupus nephritis was the most common diagnosis observed among 15.45%, followed by diabetic nephropathy in 7.27%, post infectious GN in 7.1%, renal vasculitis in 4.25% and hypertensive nephropathy in 1.52%. Among females, lupus was the most frequent pathology in that study and it corresponds to our findings [28]. However, another study done on the same settings in the period of 2015-2018 found that MCD was the most common histopathological diagnosis (86/345) followed by lupus (20%), FSGS (14%), IgAN (12%), DN (10%) and MGN (9%) [27].…”

Section: Discussionsupporting

confidence: 88%

“…Whereas in the secondary forms of GN, lupus was the most common followed by DN and amyloidosis [27]. Another retrospective study done at Kandy teaching hospital Sri Lanka with a total of 2680 biopsies during the period of 2010 to 2019 showed that among primary GN, FSGS as the most common diagnosis observed in 11.41% biopsies [28]. Among secondary GN, lupus nephritis was the most common diagnosis observed among 15.45%, followed by diabetic nephropathy in 7.27%, post infectious GN in 7.1%, renal vasculitis in 4.25% and hypertensive nephropathy in 1.52%.…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological spectrum of biopsy-proven renal diseases of patients at a single center in Sri Lanka: a cross sectional retrospective review

et al. 2023

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Background The clinical presentation of renal diseases can vary widely. The lack of a comprehensive national registry for Sri Lanka makes it difficult to provide a detailed record of the various clinical presentations and histopathology of renal disorders in the nation. Therefore, this study aims to provide a record of the spectrum of renal diseases in Sri Lanka. Methods Renal biopsies performed at the nephrology unit in Colombo South Teaching Hospital (CSTH), Sri Lanka from March 2018 to October 2019 was retrospectively studied. Indications for renal biopsy were nephrotic range proteinuria, sub nephrotic range proteinuria, acute kidney injury without obvious etiology, chronic renal disease without obvious etiology and haematuria. Results A total of 140 native kidney biopsies were analyzed in which majority were females (55.7%). The mean age of the population was 46 ± 15.3 years. The most common indications for renal biopsy were nephrotic range proteinuria (54.3%), followed by sub-nephrotic range proteinuria (14.3%), nephrotic range proteinuria with haematuria (14.3%), sub-nephrotic range proteinuria with haematuria (9.3%), AKI without known cause (4.3%), and CKD without known cause (3.6%). The leading histopathological diagnoses were FSGS (22.1%), lupus nephritis (20%), PSGN (17.1%), DN (12.1%), HTN (9.3%), MCD (6.4%), IgA nephropathy (5.7%), IN (4.3%), vasculitis (2.1%), and MGN (0.7%). Conclusions The most common indication for renal biopsy was nephrotic range proteinuria in our population. FSGS was the most prevalent histopathological diagnosis and the least frequent diagnosis reported was MGN. The spectrum of renal diseases could differ according to the study location and it changes over time. Therefore, a renal biopsy registry is needed for documenting the changing disease pattern in Sri Lanka.

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