Spanish multicenter study to estimate the incidence of chronic pancreatitis

Muñoz, J.E. Domínguez; Villarín, Alfredo José Lucendo; Álvarez, Lourdes Sanz; Tenías, José María; García, J. Iglesias

doi:10.17235/reed.2016.4056/2015

Cited by 24 publications

(23 citation statements)

References 25 publications

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“…CP, the most common cause of PEI, has a prevalence of 13.5-49.3 in 100,000 in the general population; the prevalence of PEI in these patients has been proposed to occur in 35-50% of patients 10-15 years after onset [37,50]. As already noted, PEI is present at birth in 85% of infants with CF, a disease in which it is caused by blocking of the exocrine gland with viscous secretions [51].…”

Section: Prevalence Of Pancreatic Exocrine Insufficiency In Pancreatimentioning

confidence: 95%

“…The high rate of undiagnosed PEI in patients with chronic pancreatic diseases, including CP, CF, and pancreatic cancer, justifies the need for routine pancreatic functional testing in these populations to help identify those in need of PERT [1,37,50]. Compared with the 72-h fecal fat test and the 13 C-breath test, the FE-1 test is more suitable for screening patients for PEI because it is less time-consuming, is less unpleasant for the patient, and can detect altered pancreatic function of all severities (although limited for mild PEI [65%] compared with moderate-tosevere impairment [*100%]), while the 72-h fecal fat test cannot (Fig.…”

Section: Recommendations For Fe-1 Testing In Different Patient Populamentioning

confidence: 99%

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Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test

et al. 2017

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The early diagnosis of pancreatic exocrine insufficiency (PEI) is hindered because many of the functional diagnostic techniques used are expensive and require specialized facilities, which prevent their widespread availability. We have reviewed current evidence in order to compare the utility of these functional diagnostic techniques with the fecal elastase-1 (FE-1) test in the following three scenarios: screening for PEI in patients presenting with symptoms suggestive of pancreatic disease, such as abdominal pain or diarrhea; determining the presence of PEI in patients with an established diagnosis of pancreatic disease, such as chronic pancreatitis or cystic fibrosis; determining exocrine status in disorders not commonly tested for PEI, but which have a known association with this disorder. Evidence suggests the FE-1 test is reliable for the evaluation of pancreatic function in many pancreatic and non-pancreatic disorders. It is non-invasive, is less time-consuming, and is unaffected by pancreatic enzyme replacement therapy. Although it cannot be considered the gold-standard method for the functional diagnosis of PEI, the advantages of the FE-1 test make it a very appropriate test for screening patients who may be at risk of this disorder.

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Section: Prevalence Of Pancreatic Exocrine Insufficiency In Pancreatimentioning

confidence: 95%

Section: Recommendations For Fe-1 Testing In Different Patient Populamentioning

confidence: 99%

Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test

et al. 2017

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“…The etiologic spectrum of CP overlaps with RAP, but is narrower, with alcohol by far being the most common etiology, followed by idiopathic and genetic etiologies. 14, 31, 34, 41 Table 1 shows a non-exhaustive list of causes of RAP and CP, of which select are discussed below.…”

Section: Etiologymentioning

confidence: 99%

Epidemiology of Recurrent Acute and Chronic Pancreatitis: Similarities and Differences

2017

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Emerging data in the past few years suggest that acute (AP), recurrent acute (RAP) and chronic pancreatitis (CP) represent a disease continuum. This review discusses the similarities and differences in the epidemiology of RAP and CP. RAP is a high-risk group, comprised of individuals at varying risk of progression. The premise is that RAP is an intermediary stage in the pathogenesis of CP, and a subset of RAP patients during their natural course transition to CP. Although many clinical factors have been identified, accurately predicting the probability of disease course in individual patients remains difficult. Future studies should focus on providing more precise estimates of the risk of disease transition in a cohort of patients, quantification of clinical events during the natural course of disease, and discovery of biomarkers of the different stages of the disease continuum. Availability of clinically-relevant endpoints and linked biomarkers will allow more accurate prediction of the natural course of disease over an intermediate or long term based characteristics of an individual patient. These endpoints will also provide objective measures for use in clinical trials of interventions that aim to alter the natural course of disease.

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“…[1] Kronik pankreatitin görülme sıklığı net bilinmemekle birlikte, Yadav D. [2] ve arkadaşları kronik pankreatit insidansı ve prevalansı hakkında yaptıkları çalışmada, kronik pankreatit insidansını 4.05/100000, prevalansını ise 41.76/100000 olarak saptamışlardır. Domínguez Muñoz JE [3] ve arkadaşlarının kronik pankreatitlerin insidansını araştırmaya yönelik çalışmasına göre; kronik pankreatit insidansı yıllık 4.66/100000'dir. Kronik pankreatitin erkeklerde daha sık görüldüğü de saptanmıştır.…”

Section: Discussionunclassified

Nonneoplastic lesions of the pancreas: retrospective analysis of 20 cases

Tunçel¹

2018

Sisli Etfal

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P ankreasın lezyonları nonneoplastik ve neoplastik olarak 2 kategori şeklinde değerlendirilir. [1] Nonneoplastik lezyonlar konjenital anomaliler (anüler pankreas, heterotopik pankreas), pankreatit, abse ve granülomatöz inflamasyon, psödokistler ve gerçek kistleri içermektedir. [1] Neoplastik lezyonlar ise duktal adenokarsinom, anaplastik karsinom, kistik pankreatik neoplazmlar, intraduktal papiller müsinöz neoplazm ve PanIN, asiner hücreli tümörler, solid-psödopapiller tümör, pankreatoblastom, diğer epitelyal ekzokrin tümörler, endokrin tümörler, len-foid tümörler, mezenkimal tümörler ve metastatik tümörlerden oluşmaktadır. [1] Bu çalışmada retrospektif olarak 12 yılda gerçekleşen pankreatektomi olguları içerisinde raporlanmış nonneoplastik lezyonların klinik ve histopatolojik olarak değerlendirilmesi amaçlanmıştır. Yöntem Kliniğimizde Ocak 2004 ile Haziran 2016 tarihleri arasında raporlanmış 122 pankreatektomi olgusu, pankreasın nonneoplastik lezyonları açısından klinik bulguları ve Amaç: Pankreatik lezyonlarda girişimsel işlem yapılmasının zorluğu ve sitopatolojik değerlendirmenin sınırlı olması yanısıra malignite riskinin yüksek olması nedeniyle sıklıkla preoperatif histolojik tanı olmadan görüntüleme yöntemleriyle operasyon planlanmaktadır. Bu çalışmada 12 yılda gerçekleşen pankreatektomi olgularından postoperatif pankreasın nonneoplastik lezyonları tanısı alan 20 olgunun retrospektif olarak detaylı klinik ve histopatolojik olarak değerlendirilmesi amaçlanmıştır. Yöntem: Kliniğimizde 2004 2016 tarihleri arasında raporlanmış 122 pankreatektomi olgusu pankreasın nonneoplastik lezyonları açısından klinik bulguları ve histopatolojik tanıları ile retrospektif olarak değerlendirilmiştir.

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Spanish multicenter study to estimate the incidence of chronic pancreatitis

Cited by 24 publications

References 25 publications

Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test

Potential for Screening for Pancreatic Exocrine Insufficiency Using the Fecal Elastase-1 Test

Epidemiology of Recurrent Acute and Chronic Pancreatitis: Similarities and Differences

Nonneoplastic lesions of the pancreas: retrospective analysis of 20 cases

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