2024
DOI: 10.7554/elife.93877.1
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SPARK regulates AGC kinases central to the Toxoplasma gondii asexual cycle

Alice L. Herneisen,
Michelle L. Peters,
Tyler A. Smith
et al.

Abstract: Apicomplexan parasites balance proliferation, persistence, and spread in their metazoan hosts. AGC kinases, such as PKG, PKA, and the PDK1 ortholog SPARK, integrate environmental signals to toggle parasites between replicative and motile life stages. Recent studies have cataloged pathways downstream of apicomplexan PKG and PKA; however, less is known about the global integration of AGC kinase signaling cascades. Here, conditional genetics coupled to unbiased proteomics demonstrates that SPARK complexes with an… Show more

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