Spatial and temporal distribution of dengue in Brazil, 1990 - 2017

Andrioli, Denise Catarina; Lutinski, Junir Antônio

doi:10.1371/journal.pone.0228346

Cited by 42 publications

(40 citation statements)

References 31 publications

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“…In the analyzed period, 509 261 cases of dengue were confirmed in the Northeast, an incidence rate of 224 cases per 100 000 inhabitants. This result is close to that found in a study carried out in Brazil between 1990 and 2017, which found an incidence rate for the northeast region of 246 cases per 100 000 inhabitants (Table 1 ) [ 7 ]. The semiarid climate, which is predominant in the Northeast, combined with poor sociodemographic conditions may contribute to the high rates of dengue in this region [ 28 ].…”

Section: Discussionsupporting

confidence: 90%

“…The year 2015 was responsible for the majority of cases registered in the period (43.2%) (Table 1 ). This year was marked by one of the largest dengue epidemics that Brazil has ever had, with 1 688 688 cases recorded, an incidence of 826 cases per 100 000 inhabitants, and co-circulation of the four DENV serotypes [ 7 , 10 ]. On the other hand, in 2017 there was a drastic reduction in dengue incidence compared to previous years.…”

Section: Discussionmentioning

confidence: 99%

“…From 2010 to 2019, more than 16 million cases of dengue were reported throughout the American continent and about 10 million cases (~ 62%) were reported only in Brazil [ 6 ]. The disease is an important public health concern in the country, with simultaneous circulation of the four viral serotypes (DENV1, DENV2, DENV3, and DENV4) [ 7 ]. Dengue has a wide geographical distribution in the country and, despite the intensification of control measures, there has been an increase in the number of severe cases, hospitalizations and deaths in recent years [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study

et al. 2020

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Background Dengue fever is an arthropod-borne viral disease caused by dengue virus (DENV) and transmitted by Aedes mosquitoes. The Northeast region of Brazil is characterized by having one of the highest dengue rates in the country, in addition to being considered the poorest region. Here, we aimed to identify spatial clusters with the highest dengue risk, as well as to analyze the temporal behavior of the incidence rate and the effects of social determinants on the disease transmission dynamic in Northeastern Brazil. Methods This is an ecological study carried out with all confirmed cases of dengue in the Northeast Brazil between 2014 and 2017. Data were extracted from the National Notifiable Diseases Information System (SINAN) and the Brazilian Institute of Geography and Statistics (IBGE). Local empirical Bayesian model, Moran statistics and spatial scan statistics were applied. The association between dengue incidence rate and social determinants was tested using Moran’s bivariate correlation. Results A total of 509 261 cases of dengue were confirmed in the Northeast during the study period, 53.41% of them were concentrated in Pernambuco and Ceará states. Spatial analysis showed a heterogeneous distribution of dengue cases in the region, with the highest rates in the east coast. Four risk clusters were observed, involving 815 municipalities (45.45%). Moreover, social indicators related to population density, education, income, housing, and social vulnerability showed a spatial correlation with the dengue incidence rate. Conclusions This study provides information on the spatial dynamics of dengue in northeastern Brazil and its relationship with social determinants and can be used in the formulation of public health policies to reduce the impact of the disease in vulnerable populations.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study

et al. 2020

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“…Dengue virus (DENV) has been endemic in the northeastern region of Brazil for over 30 years, with circulation of the four serotypes (DENV 1–4), causing a significant number of cases and several outbreaks in all states of the region [ 1 , 2 ]. The chikungunya virus (CHIKV) was detected in the Americas in 2014 [ 3 ] and caused a major epidemic in 2017 with approximately 190,000 cases reported in Brazil, with 173 deaths, according the SINAN (Portuguese acronym for Notifiable Diseases Information System, official epidemiologic suveilance).…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence, spatial dispersion and factors associated with flavivirus and chikungunya infection in a risk area: a population-based seroprevalence study in Brazil

et al. 2020

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Background The State of Ceará, in Northeastern Brazil, suffers from a triple burden of arboviruses (dengue, Zika and chikungunya). We measured the seroprevalence of chikungunya, dengue and Zika and its associated factors in the population of Juazeiro do Norte, Southern Ceará State, Brazil. Methods A cross-sectional study of analytical and spatial analysis was performed to estimate the seroprevalence of dengue, Zika and chikungunya, in the year 2018. Participants were tested for IgM and IgG against these three viruses. Those with IgM and/or IgG positive tests results were considered positive. Poisson regression was used to analyze the factors associated with positive cases, in the same way that the spatial analysis of positive cases was performed to verify whether the cases were grouped. Results Of the 404 participants, 25.0% (103/404) were positive for CHIKV, 92.0% (373/404) for flavivirus (dengue or Zika) and of these, 37.9% (153/404) samples were classified as probable dengue infection. Of those who reported having had an arbovirus in the past, positive CHIKV cases had 58.7% arthralgia (PR = 4.31; 95% CI: 2.06–9.03; p = 0.000) mainly in the hands, ankles and feet. Age over 60 years had a positive association with cases of flavivirus (PR = 1.29; 95% CI: 1.09–1.54; p = 0.000). Fever, muscle pain, joint pain and skin rash were the most reported symptoms (46.1, 41.0, 38.3 and 28.41%, respectively). The positive cases of chikungunya and dengue or Zika were grouped in space and the city center was most affected area. Conclusions Four years after the introduction of CHIKV, where DENV has been in circulation for over 30 years, 1/4 of the population has already been exposed, showing the extent of the epidemic. The measured prevalence was much higher than that reported by local epidemiological surveillance.

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“…Dengue fever (DF) is an arthropod‐borne infection; however, dengue viruses 1‐4 (DENV 1‐4) can also be transmitted by blood transfusion 1‐3 . DF is a public health issue in Brazil, where the number of suspected cases corresponded to 55% of the 18 million cases reported across the American continent between 1995 and 2015 4 . In 2019, a total of 1 544 987 cases were reported in the country, an increase of almost six times over that observed in 2018 5 .…”

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confidence: 99%

Vaso‐occlusive crisis in a sickle cell patient after transfusion‐transmitted dengue infection

et al. 2020

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Case Report A 26‐year‐old woman with sickle cell disease (SCD) on chronic transfusion therapy complained of severe arthralgia, myalgia, abdominal pain, headache, and fever 24 hours after transfusion of a red blood cells (RBCs). Dengue virus (DENV) infection was suspected and the patient was hospitalized for clinical support and RBC transfusion, to lower the hemoglobin S to less than 30%. The patientʼs clinical condition improved approximately 8 days after the onset of symptoms. Results DENV type 2 (DENV‐2) TaqMan real‐time polymerase chain reaction was negative in the patient's pretransfusion sample while the posttransfusion sample was positive (Ct, 27.8), suggesting a high viral load and an acute infection. To investigate DENV transfusion transmission (TT‐DENV) the stored donor serum was tested and was also positive (Ct, 25.8). Molecular typing confirmed the presence of DENV‐2. The phylogenetic analysis of the DENV‐2 strains obtained from both donor and patient samples were classified as the Southeast Asia‐American genotype (Genotype III) and demonstrated 100% genomic identity, indicating TT‐DENV. Conclusion This is the first description of TT‐DENV in a SCD patient. A presumed high viral load in the transfused RBC unit probably determined the early clinical manifestation. In endemic regions dengue fever should be considered as differential diagnosis in SCD patients with fever and acute pain crisis, mainly during DENV outbreaks.

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Spatial and temporal distribution of dengue in Brazil, 1990 - 2017

Cited by 42 publications

References 31 publications

Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study

Spatiotemporal dynamics, risk areas and social determinants of dengue in Northeastern Brazil, 2014–2017: an ecological study

Seroprevalence, spatial dispersion and factors associated with flavivirus and chikungunya infection in a risk area: a population-based seroprevalence study in Brazil

Vaso‐occlusive crisis in a sickle cell patient after transfusion‐transmitted dengue infection

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